Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to ....Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to use innovative technology with expected high economic potential, and benefit small biotech companies by facilitating pre-clinical and clinical development of new pharmaceuticals. The new motion tracking and image reconstruction technologies developed will strengthen Australia's leading position in engineering and biomedical systems development.Read moreRead less
Novel Motion Correction Technologies for Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging. The recent development of the world's first prototype combined MR-PET scanner for human use has prompted immense interest. MR-PET is likely to revolutionize clinical diagnosis and basic research, by providing exquisite structural images co-registered with simultaneous functional PET images. We will exploit the as yet unexplored potential for motion information derived from the MR sy ....Novel Motion Correction Technologies for Simultaneous Positron Emission Tomography and Magnetic Resonance Imaging. The recent development of the world's first prototype combined MR-PET scanner for human use has prompted immense interest. MR-PET is likely to revolutionize clinical diagnosis and basic research, by providing exquisite structural images co-registered with simultaneous functional PET images. We will exploit the as yet unexplored potential for motion information derived from the MR system to be used to correct the simultaneously acquired PET data for patient motion. This research is an excellent opportunity for Australian researchers to make important contributions to an emerging technology with high economic potential, and will strengthen Australia's international position in engineering and biomedical systems development.Read moreRead less
Massive black holes in the hearts of galaxies. This research will create new insights into the extreme physics of supermassive black holes at the centres of galaxies. Using new instrumentation and analysis techniques to measure the polarisation and variability of their radiation, we will develop models for the infall of gas, the structures surrounding black holes and the merger of massive black holes over cosmic time. The new observing modes that we will develop will provide stepping stones to ....Massive black holes in the hearts of galaxies. This research will create new insights into the extreme physics of supermassive black holes at the centres of galaxies. Using new instrumentation and analysis techniques to measure the polarisation and variability of their radiation, we will develop models for the infall of gas, the structures surrounding black holes and the merger of massive black holes over cosmic time. The new observing modes that we will develop will provide stepping stones toward the Square Kilometre Array, a multi-billion dollar project from which Australia stands to reap enormous scientific and economic benefit. The major advances that we will deliver will boost Australia's already outstanding track record as a world leader in astronomical discovery.
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The Southern Sky Survey. The Southern Sky Survey will create the first digital map of the southern sky, providing a community available database of a billion objects. This database will be used by entire community, with our group targetting four key areas including: studying the creation of our solar system through a census of distant asteroids, exploring how stars and planets form by observing nearby young stars, probing the shape and extent of the Galaxy's dark matter halo, and discovering whe ....The Southern Sky Survey. The Southern Sky Survey will create the first digital map of the southern sky, providing a community available database of a billion objects. This database will be used by entire community, with our group targetting four key areas including: studying the creation of our solar system through a census of distant asteroids, exploring how stars and planets form by observing nearby young stars, probing the shape and extent of the Galaxy's dark matter halo, and discovering when the first stars in the Universe formed. This data set will also be used as a staging ground for a Virtual Observatory.
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Synchrotrons, wavelet analysis and novel imaging techniques - applying physics tools to the war against breast cancer. Breast cancer leads to the second highest number of person-years of life lost due to cancer in Australia, with little known about its transport around the body. Current screening methods for breast cancer are neither 100% sensitive or specific and are heavily dependent upon expert training. This project will contribute by yielding valuable information on the transport of breast ....Synchrotrons, wavelet analysis and novel imaging techniques - applying physics tools to the war against breast cancer. Breast cancer leads to the second highest number of person-years of life lost due to cancer in Australia, with little known about its transport around the body. Current screening methods for breast cancer are neither 100% sensitive or specific and are heavily dependent upon expert training. This project will contribute by yielding valuable information on the transport of breast cancer and contribute to the development of an automated diagnostic method, with the possibility of its application to other diseases. The project will also involve members of the regional community, train regional scientists and provide synchrotron experience for Australian scientists in time for Australia's first synchrotron.Read moreRead less
Left-handed metamaterials and negative refraction. This project will establish and support the first team in Australia working in the field of left-handed metamaterials, artificial materials in which waves behave in a unique and counter-intuitive way. The project will promote this new field, enhance its rapid development, and facilitate emerging novel technologies in Australia. It will also lead to close international collaborations with active theoretical and experimental groups, and bring impo ....Left-handed metamaterials and negative refraction. This project will establish and support the first team in Australia working in the field of left-handed metamaterials, artificial materials in which waves behave in a unique and counter-intuitive way. The project will promote this new field, enhance its rapid development, and facilitate emerging novel technologies in Australia. It will also lead to close international collaborations with active theoretical and experimental groups, and bring important expertise to Australia. We believe our initial efforts of purely fundamental nature and extensive collaboration with the overseas groups will have a significant impact on the development of this field and related novel technologies in Australia, attracting strong interest from industry.Read moreRead less
Nonlinear Dynamics of Pulse Coupled Oscillators. A mathematical model of the heart pacemaker system will be created, based on simple interacting units. These units have been shown to be good models of physiological information e.g. the discrimination of different influences on heart rate. We will firstly look at the interaction of the units in simple combinations and then tune the model to mimic the behaviour of the cardiac pacemaker.
Potential benefits may arise from elucidating the mechanis ....Nonlinear Dynamics of Pulse Coupled Oscillators. A mathematical model of the heart pacemaker system will be created, based on simple interacting units. These units have been shown to be good models of physiological information e.g. the discrimination of different influences on heart rate. We will firstly look at the interaction of the units in simple combinations and then tune the model to mimic the behaviour of the cardiac pacemaker.
Potential benefits may arise from elucidating the mechanisms underlying arrhythmias which contribute to ?sudden cardiac death? in young men, and suggesting strategies for artificial pacemakers to effectively arrest abnormal rhythms before they convert to potentially fatal fibrillation.Read moreRead less
Improving optical data storage and micromachining technology through better modelling and characterisation of their laser beams. The laser sources generally do not have simple (Gaussian) distributions. The applicant has recently developed a model, describing free propagation of complex (non-Gaussian) laser beams. This project seeks to develop a comprehending model for laser beams propagation through complex optical systems. The effects of various optical elements will be defined employing a no ....Improving optical data storage and micromachining technology through better modelling and characterisation of their laser beams. The laser sources generally do not have simple (Gaussian) distributions. The applicant has recently developed a model, describing free propagation of complex (non-Gaussian) laser beams. This project seeks to develop a comprehending model for laser beams propagation through complex optical systems. The effects of various optical elements will be defined employing a novel method known as SAFE (Stable Aggregate of Flexible Elements) which is a compromise between geometrical and physical optics. Applying this model to micromachining and optical data storage (ODS), which need high beam quality (low divergence and good focussibility), enable accurate predictive capability critical to the optimisation of micromachining and ODS designs.Read moreRead less
Universal quantum imaging. This project will integrate quantum technology with the rapidly advancing techniques of spatial light modulation utilised in LCD displays and video projectors. We will develop, for the first time, broadly versatile imaging technology based on quantum mechanics, enabling both important applications in future medical diagnostic devices and communication systems; and fundamental advances in the biological and quantum sciences. Quantum technologies offer the promise to rev ....Universal quantum imaging. This project will integrate quantum technology with the rapidly advancing techniques of spatial light modulation utilised in LCD displays and video projectors. We will develop, for the first time, broadly versatile imaging technology based on quantum mechanics, enabling both important applications in future medical diagnostic devices and communication systems; and fundamental advances in the biological and quantum sciences. Quantum technologies offer the promise to revolutionise many aspects of modern life, from computing and communications, to medical imaging and metrology. This project will put Australia at the international forefront of quantum imaging, enhancing Australia's already significant international presence in the area.Read moreRead less
Snap, Crackle, Pop: Opening the Window on the Variable Radio Universe. Time variability is a frontier of discovery in astronomy. We will conduct a comprehensive set of surveys with new radio telescopes and instruments in order to build a full census of bursts, pulses, and flickers in the radio sky. Coupled with rapid follow up observations in the optical, X-ray and gamma-ray bands, these surveys will allow us to probe fundamental physics behind violent and unpredictable behaviour in the Universe ....Snap, Crackle, Pop: Opening the Window on the Variable Radio Universe. Time variability is a frontier of discovery in astronomy. We will conduct a comprehensive set of surveys with new radio telescopes and instruments in order to build a full census of bursts, pulses, and flickers in the radio sky. Coupled with rapid follow up observations in the optical, X-ray and gamma-ray bands, these surveys will allow us to probe fundamental physics behind violent and unpredictable behaviour in the Universe. Our techniques, pipelines, and algorithms will serve as stepping stones for future experiments, and will also have wide applicability to searches for weak signals in noisy data in areas including physics, ecology, medical science, and economics.Read moreRead less