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Mechanisms Regulating The Levels Of Circulating Insulin In Response To Nutrition
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Diabetes is the fastest growing chronic disease both in Australia and worldwide, caused by the failure of cells within the pancreas to produce sufficient insulin. I aim to determine how different nutritional inputs alter the levels of circulating insulin, and identify and characterise genes required for insulin production and secretion. As well as providing important insights into the mechanisms that regulate insulin secretion, I will identify new therapeutic targets for diabetes treatment.
The Physiological And Pathological Role Of The Bile Acid Receptor TGR5 And Its Potential Targeting For The Treatment Of Intestinal Motility Disorders And Visceral Pain.
Funder
National Health and Medical Research Council
Funding Amount
$311,860.00
Summary
Defects in the secretion of bile into the intestine cause digestive diseases, and abnormal circulating levels of bile acids induce profound itch and abnormal pain sensation. This project examines whether a cell-surface receptor (TGR5) produced by intestinal and sensory neurons mediates actions of bile acids on intestinal functions and pain. The project aims to define mechanisms of digestive and sensory disorders and identify new therapies for constipation, diarrhoea, and pain.
Mechanisms Responsible For Pancreatic Beta Cell Death And Dysfunction
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Diabetes is the fastest growing chronic disease both in Australia and worldwide. Current treatments are lacking effectiveness. Therefore, there is an urgent need to revolutionise diabetes therapy. Diabetes is caused by the failure of cells within the pancreas to produce sufficient insulin, resulting in uncontrolled blood sugar levels. This research proposal aims to investigate the processes and factors leading to this phenomenon in order to develop new strategies to overcome them.