The Role Of Insulin Hypersecretion In Beta Cell Dysfunction In Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$318,622.00
Summary
The treatment of diabetes involves the use of drugs that stimulate the release of insulin from the pancreas to reduce the high blood sugar levels. However, we believe that while in the short term this is a good strategy, in the long-term it damages the cells that produce insulin leading to a worsening state of diabetes. It is the aim of this application to understand the mechanisms by which the insulin producing cells are damaged when forced to oversecrete insulin.
Mechanistic And Translational Studies Of A New Therapeutic For The Treatment Of Obesity And Type 2 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
Diabetes develops when beta-cells are no longer able to secrete enough insulin to control blood glucose. This research project will identify factors which regulate beta-cell function and identify means of regulation.