Common Susceptibility Genes Underlying The Idiopathic Generalized Epilepsies (IGE) - A Genome-wide Scanning Approach
Funder
National Health and Medical Research Council
Funding Amount
$212,063.00
Summary
Epilepsy is the most common serious brain condition. Seizures affect about 10% of people at some time in their life and their consequences are an important public health problem. The most common group of inherited epilepsies account for about 30% of childhood epilepsy and 20% of adult epilepsy. This study will be the first in Australia and one of only a few worldwide to take a population-based approach to investigating the link between epilepsy and genetic inheritance.
NPY Suppresses Seizures And Modulates Thalamocortical Activity In Animal Models Of Generalized Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$386,020.00
Summary
Epilepsy is the most common serious chronic neurological disease in the community, affecting up to 3% of the population in a lifetime and 0.5-1% at any one time. Absence epilepsy is one of the most common types of epilepsy, most frequently seen in childhood and teenage years that may persist into adulthood. Anti-epileptic drugs are effective in controlling absence seizures in most patients, however there is an important group (20-40%) of patients in whom the absence seizures remain uncontrolled ....Epilepsy is the most common serious chronic neurological disease in the community, affecting up to 3% of the population in a lifetime and 0.5-1% at any one time. Absence epilepsy is one of the most common types of epilepsy, most frequently seen in childhood and teenage years that may persist into adulthood. Anti-epileptic drugs are effective in controlling absence seizures in most patients, however there is an important group (20-40%) of patients in whom the absence seizures remain uncontrolled with current medications. Recently there has been considerable interest in the role that chemical in the brain, such as neuropeptide Y (NPY), may play in epilepsy. The research proposed will examine the role of NPY in several animal models of absence epilepsy. We have recently shown that NPY suppresses absence seizures in a rat genetic model of generalised epilepsy, and that this appears to be mediated by Y2 receptors. This work will build on these novel findings, and determine the localisation of the effect within the brain, and the underlying mechanism. We will check NPY effects across several models in different species, a genetic rat model with spontaneous seizures, and in mice treated with a chemical to induce seizures. This will determine its broad applicability. We will also determine the effects of removal of NPY or NPY receptors on the effects of NPY on seizure expression. Finally, brain recording techniques will be applied to determine the mechanism and site within the brain underlying the protective actions of NPY. The project has the potential to provide novel insights into the role of NPY in the expression and modulation of absence seizures. NPY related mechanisms might represent targets for the development of a new class of therapeutic agents for the treatment of absence epilepsy. Targets that are identified as being important in the expression of absence seizures may also prove to be relevant in other types of generalised epilepsy syndromes.Read moreRead less
Targeting NPY Mechanisms In Rodent Models Of Generalised Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$437,637.00
Summary
This project will provide important information regarding the pharmacological mechanisms by which NPY acts to suppress seizures in animal models of epilepsy. It will provide strategies regarding potential new treatments of absence epilepsy.
Scholarship in Science Teaching: an examination of the relationships between science content, teaching and learning. Excellent science teachers have profound impact on the students they teach. A central core of their excellence is the intertwined understandings they have of the content they teach and pedagogies for teaching this (termed pedagogical content knowledge). This knowledge is largely implicit, and hence not available to others. This research will develop enhanced methodologies to doc ....Scholarship in Science Teaching: an examination of the relationships between science content, teaching and learning. Excellent science teachers have profound impact on the students they teach. A central core of their excellence is the intertwined understandings they have of the content they teach and pedagogies for teaching this (termed pedagogical content knowledge). This knowledge is largely implicit, and hence not available to others. This research will develop enhanced methodologies to document and disseminate the knowledge of practice that underpins claims of professional excellence. Such research is crucial to the national and international moves to recognise, articulate, document, justify/validate, and share professional teaching excellence.Read moreRead less
Conceptual complexity and student engagement with science in secondary school. Research demonstrates that negative student attitudes to school science are associated with the subject's difficulty and its lack of relevance to real-world experience. However, teachers who link learning to students' experience may exacerbate the difficulty of science, because real-world applications of concepts are complex. This study will initially investigate teachers' perceptions of this dilemma, and then focus ....Conceptual complexity and student engagement with science in secondary school. Research demonstrates that negative student attitudes to school science are associated with the subject's difficulty and its lack of relevance to real-world experience. However, teachers who link learning to students' experience may exacerbate the difficulty of science, because real-world applications of concepts are complex. This study will initially investigate teachers' perceptions of this dilemma, and then focus on two classrooms where teachers acknowledge the complexity involved. Using a novel conceptual framework and an innovative data collection technique the study will explore how the students? experiences of complexity shape their attitudes to science. The findings will help improve student engagement with science.Read moreRead less
Engaging science students' hearts and minds: Researching science teachers' professional learning in the development of contemporary understandings of scientific literacy. This project will develop, support and value the work of science teachers in developing students' scientific literacy and share the subsequent knowledge gains in the educational community to positively advance quality teaching and learning in school science. Improving science teaching and learning hinges on offering new ways of ....Engaging science students' hearts and minds: Researching science teachers' professional learning in the development of contemporary understandings of scientific literacy. This project will develop, support and value the work of science teachers in developing students' scientific literacy and share the subsequent knowledge gains in the educational community to positively advance quality teaching and learning in school science. Improving science teaching and learning hinges on offering new ways of responding to the problems inherent in teaching science in the 21st century. By supporting and encouraging the creative and innovative ideas, concepts and approaches to quality science teaching and learning embedded in teachers' professional learning the development of the critical knowledge for challenging the status-quo will be advanced.Read moreRead less
Adolescent mental health and supportive classroom environments: investigating organizational supports as mediators to a sustainable reduction in aggressive classroom management. Making classrooms safe and supportive for all students enables young Australians to lead healthier and more productive lives through social inclusion and economic participation. Finding effective ways to reduce teachers' use of non-productive, aggressive strategies in interactions with challenging students offers importa ....Adolescent mental health and supportive classroom environments: investigating organizational supports as mediators to a sustainable reduction in aggressive classroom management. Making classrooms safe and supportive for all students enables young Australians to lead healthier and more productive lives through social inclusion and economic participation. Finding effective ways to reduce teachers' use of non-productive, aggressive strategies in interactions with challenging students offers important social and economic benefits to Australia. These include reductions in adolescent anxiety and depression, greater engagement in schooling, a reduction in student withdrawals and exclusions, increasing parent, community and international confidence in Australia's schools, and a reduction in the number of young teachers leaving the profession.Read moreRead less
Detection Of Somatic Mutations In Sporadic Epilepsies
Funder
National Health and Medical Research Council
Funding Amount
$1,256,166.00
Summary
Finding genetic causes of epilepsies is essential for refining treatments and genetic counseling. Genetic mutations may occur after fertilization (somatic mutations). These can be difficult to detect by routine genetic tests. We aim to identify somatic mutations by: very deep sequencing of blood to find low concentrations of mutations, analysing DNA from the cerebrospinal fluid, and analysing DNA obtained from the back of the nose which is closely related to brain tissue.
Influences on students' learning goals and their capacity for self-regulation. There is an obvious connection between maximizing learning of young people and the nation's future. Currently many young people are missing opportunities for learning at school, and this not only reduces their own opportunities, thereby increasing their risk of long term dependence on government services, but also reduces overall social capital. The project will evaluate teaching strategies that have potential to enha ....Influences on students' learning goals and their capacity for self-regulation. There is an obvious connection between maximizing learning of young people and the nation's future. Currently many young people are missing opportunities for learning at school, and this not only reduces their own opportunities, thereby increasing their risk of long term dependence on government services, but also reduces overall social capital. The project will evaluate teaching strategies that have potential to enhance the participation of students in learning in the middle years.
The project will be of direct benefit to regional and rural communities since it is conducted in regional and rural schools with their particular challenges, including community pessimism, reduced vocational aspirations, and limited role models.
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A Systematic Evaluation Of The Neurosurgical Application Of Peri-operative And Intra-operative MR Tractography In Different Paediatric Disease States
Funder
National Health and Medical Research Council
Funding Amount
$130,910.00
Summary
My research investigates changes in brain nerve fibre tracts/white matter in paediatric disease states and changes related to surgery by using nerve fibre tract imaging before, during and after surgery. It will also generate an imaging atlas to help understand white matter pathway development. It then serves as normative comparison to better understand aberrations in diseased neural pathways. The outcome will aid understanding in brain development, recovery and plasticity, and helps improve whit ....My research investigates changes in brain nerve fibre tracts/white matter in paediatric disease states and changes related to surgery by using nerve fibre tract imaging before, during and after surgery. It will also generate an imaging atlas to help understand white matter pathway development. It then serves as normative comparison to better understand aberrations in diseased neural pathways. The outcome will aid understanding in brain development, recovery and plasticity, and helps improve white matter lesion localisation.Read moreRead less