Improving engagement in learning and transition to mainstream schooling for newly-arrived Sudanese youth in the middle years of schooling. The 'new wave' of Sudanese refugees (48.3% of 2003 intake) with disrupted educational and social/emotional backgrounds is currently challenging Australian schools' expertise and resources. Using frameworks that draw on cultural theory, identity and language, the study will explore the social capital needs (skills and capacities, and resource needs) of Sudanes ....Improving engagement in learning and transition to mainstream schooling for newly-arrived Sudanese youth in the middle years of schooling. The 'new wave' of Sudanese refugees (48.3% of 2003 intake) with disrupted educational and social/emotional backgrounds is currently challenging Australian schools' expertise and resources. Using frameworks that draw on cultural theory, identity and language, the study will explore the social capital needs (skills and capacities, and resource needs) of Sudanese middle-schooling students enabling successful, productive and engaged transition from their on-arrival program into mainstream secondary schooling. The resulting model and web-based materials will provide a framework for educating other groups likely to follow from Africa/elsewhere, and meet the National Priority Goal: strengthening Australia's social fabric.Read moreRead less
Statistical Methods For Identifying Structural Variation In Tumour Genomes Using Next Generation Sequencing
Funder
National Health and Medical Research Council
Funding Amount
$243,458.00
Summary
New DNA sequencing technology can sequence a tumour genome affordably in 2 weeks. This re-sequencing data can be used to find small mutations and large-scale chromosomal rearrangements that together are the drivers of cancer. These may one day be used to guide cancer therapy. This project will develop new algorithms for finding mutations and apply these to discover the genetic basis of drug resistance in a model lymphoma system.
Detection Of Somatic Mutations In Sporadic Epilepsies
Funder
National Health and Medical Research Council
Funding Amount
$1,256,166.00
Summary
Finding genetic causes of epilepsies is essential for refining treatments and genetic counseling. Genetic mutations may occur after fertilization (somatic mutations). These can be difficult to detect by routine genetic tests. We aim to identify somatic mutations by: very deep sequencing of blood to find low concentrations of mutations, analysing DNA from the cerebrospinal fluid, and analysing DNA obtained from the back of the nose which is closely related to brain tissue.
The measurement of primary traits in second language oral proficiency in second language acquisition research. The proposed research will help to inform high-quality learning outcomes for international ESL (English as a Second Language) students and students who study Japanese or Spanish as a second language in Australian universities. Improved effectiveness in current second language teaching pedagogy will result from a deeper understanding of the role that the key language traits (syntactic co ....The measurement of primary traits in second language oral proficiency in second language acquisition research. The proposed research will help to inform high-quality learning outcomes for international ESL (English as a Second Language) students and students who study Japanese or Spanish as a second language in Australian universities. Improved effectiveness in current second language teaching pedagogy will result from a deeper understanding of the role that the key language traits (syntactic complexity, lexical range, accuracy and fluency) play in the attainment of advanced proficiency. Read moreRead less
The Role Of Cellular Microdomains In G-protein Coupled Receptor Signalling.
Funder
National Health and Medical Research Council
Funding Amount
$385,297.00
Summary
Molecules communicate with cells by attaching to proteins called receptors on the outside of cells, and triggering a series of events inside the cell. These events initially include the assembly of multiple proteins at the cell surface. This project will examine the formation of receptors and other proteins into these ‘communication complexes’. This will provide novel targets for more selective drug development.
A Worldwide Study Of Cancer Risk For Lynch Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$710,761.00
Summary
People with the genetic Lynch syndrome are more likely to get cancer but we cannot accurately predict who will get cancer and when. Doctors need this information to improve cancer prevention. Large collaborative studies are needed for this research. We have agreement from the 115 researchers to combine, into a single resource, 8,863 family trees of Lynch syndrome. We will analyse this data to determine the risk of cancer and whether it differs by sex, age, or nationality.
A Functional Assay To Classify Genetic Variants In Lynch Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$368,195.00
Summary
At least one person in every 1000 is affected by Lynch syndrome, in which faulty DNA repair machinery causes high rates of cancer. People with Lynch syndrome can have their risk of cancer cut substantially with regular screening. However, we often struggle to understand whether people with 'non-standard' DNA sequences in particular genes actually have Lynch syndrome. This project develops a simple test that will tell clinicians whether a given sequence change relates to Lynch syndrome or not.
Key indicators of development in adolescent writing. The project aims to identify significant indicators of development in the writing of adolescents at various stages of secondary education. There are a number of students who struggle with the demands of secondary schooling because they have not developed control over the more abstract, technical, and metaphorical language required in written assignments and examinations. This study will map the development of those linguistic resources critica ....Key indicators of development in adolescent writing. The project aims to identify significant indicators of development in the writing of adolescents at various stages of secondary education. There are a number of students who struggle with the demands of secondary schooling because they have not developed control over the more abstract, technical, and metaphorical language required in written assignments and examinations. This study will map the development of those linguistic resources critical to success in secondary learning, drawing on and extending Halliday's functional theory of language. An understanding of typical patterns of development will enable teachers to productively intervene in those cases where students' academic progress is impeded.
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