School-Age Outcomes Of Very Preterm Infants And Antenatal Magnesium Sulphate Therapy - A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$675,050.00
Summary
Despite recent major advances in care around the time of birth that have led to large increases in the survival rates for very preterm babies, the rate of adverse long-term health problems has not diminished in survivors, and remains too high compared with children not born very preterm. In particular they have higher rates of substantial problems with the way their brain works, particularly affecting their movement, vision, hearing, thinking and talking. We have just concluded a large clinical ....Despite recent major advances in care around the time of birth that have led to large increases in the survival rates for very preterm babies, the rate of adverse long-term health problems has not diminished in survivors, and remains too high compared with children not born very preterm. In particular they have higher rates of substantial problems with the way their brain works, particularly affecting their movement, vision, hearing, thinking and talking. We have just concluded a large clinical trial in Australia and New Zealand of magnesium sulphate which was given to mothers who were likely to deliver their baby too early (before 30 weeks of pregnancy). We have been able to show, for the first time, that magnesium sulphate was able to halve the rate of substantial problems with movement in 2 year old survivors, from 6% to 3%. However, we are not sure if this potentially important improvement will translate into better outcomes for the children as they grow older and reach school-age. As there are many examples of treatments given around the time of birth that have been shown to have some short-term benefits, but substantial long-term harms, we must be as certain as we can be that any advance in one small area of health is not counterbalanced by disadvantages in other health areas. We plan to assess the 1061 survivors from our earlier clinical trial of magnesium sulphate therapy at ages from 7-8 years, when they are at school. We will assess their movement and other important areas of their brain function, as well as their school progress and general health and growth. If we find important improvements in health at school-age of these children caused by magnesium sulphate therapy, without any substantial counterbalancing side-effects, magnesium sulphate will probably become standard therapy in mothers who are likely to deliver their baby very early. This will lead to a reduction in the burden of illness in the community caused by being born too early.Read moreRead less
SCHOOL-AGE OUTCOME FOR VERY TINY/PRETERM CHILDREN BORN IN VICTORIA IN 1991-92
Funder
National Health and Medical Research Council
Funding Amount
$252,956.00
Summary
The survival rate for tiny or very premature babies has improved dramatically in recent times, from below 10% in the 1960s to greater than 70% in the 1990s. Several new treatments have helped to improve their survival rate, but some have the potential to cause long-term harm to the developing baby's brain or lung, and may cause lifelong problems with thinking, walking, talking, seeing, hearing, growth or breathing. Babies who are very tiny (born weighing less than 1000 g), or born very early (bo ....The survival rate for tiny or very premature babies has improved dramatically in recent times, from below 10% in the 1960s to greater than 70% in the 1990s. Several new treatments have helped to improve their survival rate, but some have the potential to cause long-term harm to the developing baby's brain or lung, and may cause lifelong problems with thinking, walking, talking, seeing, hearing, growth or breathing. Babies who are very tiny (born weighing less than 1000 g), or born very early (born before 28 weeks of pregnancy, or more than 12 weeks premature) will be assessed long term (to 8-9 years of age), as broadly as possible, and in comparison with normal birthweight (NBW, birthweight >2499 g) children. Outcomes will encompass academic progress and behaviour, brain function, general health, growth, and respiratory health. We will compare the outcomes for very tiny-preterm children who were treated with several of these new therapies with those who were not so treated. We will assess whether alternative measures of long term outcome that assess the quality of life are applicable to very tiny-preterm children. If so, these measures could be used much more widely, since they are cheaper and less time-consuming.Read moreRead less
A Randomised Trial Of The Augmentation Of Cognitive Behaviour Therapy With Fluoxetine For Anxious School Refusing Youth
Funder
National Health and Medical Research Council
Funding Amount
$539,191.00
Summary
School refusing youth consistently suffer from anxiety and sometimes depression. They become severely emotionally distressed when taken to school and experience social and academic difficulties in the short and long term as well as psychiatric illness in adulthood. Our program investigates whether treatment can be improved by enhancing psychotherapy (cognitive behaviour therapy) which helps over half of anxious school refusing children, with antidepressant-anxiety medication compared to placebo.
A Healthy Promoting School Approach To Encourage Children To Wear Helmets
Funder
National Health and Medical Research Council
Funding Amount
$165,708.00
Summary
Each year around sixty Australians die as a result of bicycle crashes and thousands more are injured, some so severely they are permanently disabled. The largest proportion of the population affected by bicycle-related injuries are children and adolescents. These injuries are largely preventable if riders wore helmets. Some studies suggest wearing a helmet reduces the likelihood of head injury by more than 75%. Approximately 80% of Western Australian primary school students who ride to school we ....Each year around sixty Australians die as a result of bicycle crashes and thousands more are injured, some so severely they are permanently disabled. The largest proportion of the population affected by bicycle-related injuries are children and adolescents. These injuries are largely preventable if riders wore helmets. Some studies suggest wearing a helmet reduces the likelihood of head injury by more than 75%. Approximately 80% of Western Australian primary school students who ride to school wear a helmet. Students aged 10-12 years are on the cusp of a dramatic decline in helmet usage - secondary school students helmet usage rates are observed at 43%. This project aims to provide a supportive school environment for road users, and with the assistance of their peers, skill children with strategies and dialogue to resist peer pressure not to wear a helmet in order to arrest this rate of decline when they reach secondary school. This three-year study will compare the impact of a whole-school road safety intervention based on the health promoting school model to the standard road safety curriculum. For the study cohort ie: Year 5 - 6 students, the focus will be on bicycle safety, in particular, correct helmet usage. The intervention includes innovative participatory strategies to develop a supportive school environment for road users plus peer-teacher classroom activities that encourage the correct use of bicycle helmets for Year 5 - 6 students (and their parents). The intervention trial will be conducted with 30 Western Australian primary schools in 2000 and 2001. Other target groups of the intervention are teachers, Year 7 peer teachers, school administrators and the school community. Potential benefits of this project include the provision of a model health promoting school intervention to increase the frequency of correct helmet wearing by children which in time may lead to a reduction in bicycle-related morbidity and mortality in Western Australia.Read moreRead less
Evaluation Of The Effectiveness Of Mobile Preschool For Child Health And Development In Remote Aboriginal Communities
Funder
National Health and Medical Research Council
Funding Amount
$456,369.00
Summary
This project is a retrospective study of the effectiveness of the NT Mobile Preschool Program using assessment data for children's emergent literacy, social and emotional competencies and health status. Effectiveness will be established by comparison with achievement and health status data for children not attending preschool and those in communities with no preschool service. The study will identify and describe the key factors influencing the health and learning outcomes of the three groups.
Modifiable Influences On Tobacco, Cannabis And Other Drug Use In Early Adolescence.
Funder
National Health and Medical Research Council
Funding Amount
$198,434.00
Summary
High rates of tobacco and cannabis use by Australia s young people are a continuing concern. This study will explore the factors that influence the development of drug use from late childhood. The International Youth Development Study collected data from 5,769 students in Grades 5, 7, and 9 in Washington State, U.S., and Victoria, Australia. Findings will both increase understanding of adolescent tobacco and cannabis use in the Australian context and inform prevention policy.