The Role Of The NPY System In The Regulation Of Appetite And Satiety
Funder
National Health and Medical Research Council
Funding Amount
$1,088,384.00
Summary
Eating disorders that have a causative role in the development of obesity and anorexia present massive health care problems for which current preventive methods and therapies are unsatisfactory. The studies proposed here combine sophisticated molecular techniques with state-of-the-art biochemical and physiological analyses. By utilising a panel of unique mouse models (many of which are only available to us), missing or overproducing key factors in the regulation of appetite and satiety this rese ....Eating disorders that have a causative role in the development of obesity and anorexia present massive health care problems for which current preventive methods and therapies are unsatisfactory. The studies proposed here combine sophisticated molecular techniques with state-of-the-art biochemical and physiological analyses. By utilising a panel of unique mouse models (many of which are only available to us), missing or overproducing key factors in the regulation of appetite and satiety this research will make highly original and internationally competitive contributions to the understanding of these disorders. The results will have a significant impact on the development of novel diagnostics and potential treatments for obesity and anorexia. In addition, funding provided through this grant would not only help to find answers to these important questions but will also provide the basis for the generation of several novel mouse models. These animal models will also be beneficial tools for the wider scientific community here in Australia and worldwide. We have a proven record in the generation and comprehensive analysis of transgenic and knockout mice models making this proposal not only feasible but also highly likely to succeed and provide great new insight into extremely important health problems.Read moreRead less
This study combines sophisticated molecular techniques with state-of-the-art biochemical and physiological analyses to determine how gut hormones regulate satiety. By utilising unique conditional and germline KO mice , this research will make highly original and internationally competitive contributions to the understanding of the regulation of satiety and energy expenditure. Knowledge as to the causes of lack of satiety will be of great benefit in the search for novel treatments for obesity.