The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Climate Change and Burden of Disease: Current Risk and Future Burden. Climate change has had a negative impact on human health. However, few studies have assessed burden of diseases (BOD) for these climate-sensitive/heat attributable diseases. We will generate the first national picture of the climate attributable BOD in Australia, measured in Disability-Adjusted Life Year (DALY), the attribution from climate, and project future BOD under various climatic/demographic change scenarios. This proje ....Climate Change and Burden of Disease: Current Risk and Future Burden. Climate change has had a negative impact on human health. However, few studies have assessed burden of diseases (BOD) for these climate-sensitive/heat attributable diseases. We will generate the first national picture of the climate attributable BOD in Australia, measured in Disability-Adjusted Life Year (DALY), the attribution from climate, and project future BOD under various climatic/demographic change scenarios. This project will rank Australian climate-sensitive/heat attributable diseases by their current burden and projected increase under climate changes, and provide needed scientific evidence to policy-makers in the development, prioritization and implementation of current and future climate change and health adaptation strategies. Read moreRead less
The unfolding story of the 2009 Adelaide heatwave: risk factors for mortality and morbidity. This project will conduct a case control study in Adelaide to explore the risk factors of extra health burden related to the 2009 heatwave. Given the prediction of more extreme heat events, this study will provide important information for policy makers and service providers to assist in the development of more resilient communities to climate change.