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Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities ....Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities to address current limitations in understanding the stability of magnetic nanoparticles in biological fluids. The Australian partners will play a leading role in commercializing new applications for functionalized magnetic nanoparticles. The project will provide an excellent multidisciplinary research environment and training for early career researchers.Read moreRead less
Porous Silica-Based Nanocapsules for Targeted and Controlled Release of Biocides. The project will lead to significant advances in nanotechnology and agrichemical biocide applications. A highly efficient insect control technology will be developed, that will be cost-effective with the ability for targeted control and release of biocides. The encapsulation technology will reduce the total usage and costs of biocides thus benefit the environment in terms of reduced environment pollution and enhanc ....Porous Silica-Based Nanocapsules for Targeted and Controlled Release of Biocides. The project will lead to significant advances in nanotechnology and agrichemical biocide applications. A highly efficient insect control technology will be developed, that will be cost-effective with the ability for targeted control and release of biocides. The encapsulation technology will reduce the total usage and costs of biocides thus benefit the environment in terms of reduced environment pollution and enhanced ecological safety.Read moreRead less
Quantification of airborne engineered nanoparticles: developing a scientific framework to inform their regulation and control. Despite the presence of airborne engineered nanoparticles in many commercial/research facilities, there are no established methods for their detection/characterisation. This work aims to develop a foundation for the quantitative assessment of airborne engineered nanoparticles, which is critical for controlling exposure and minimising health risks.
Detection, characteristics and dynamics of airborne engineered nanoparticles for human exposure assessment. Recent advances in nanotechnology have led to questions about the safety of airborne engineered nanoparticles in commercial and research facilities. This project aims to develop an understanding of nanoparticle emission and behaviour in the air, which is needed to control workplace exposure to these particles and minimise the risk to human health.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100067
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
The Vevo 2100 Micro-ultrasound plus LAZR Photoacoustic Imaging Platform . The Vevo 2100 micro-ultrasound plus LAZR photoacoustic imaging platform: The Vevo/LAZR ultrasound/photoacoustic imaging facility will allow researchers to achieve multiple outcomes: to visualise and quantify, non-invasively, tissue and molecular structures; the movement and behaviour of cells; and the delivery patterns of administered imaging dyes and nanoparticles in mouse models and reconstructed tissues. This will enabl ....The Vevo 2100 Micro-ultrasound plus LAZR Photoacoustic Imaging Platform . The Vevo 2100 micro-ultrasound plus LAZR photoacoustic imaging platform: The Vevo/LAZR ultrasound/photoacoustic imaging facility will allow researchers to achieve multiple outcomes: to visualise and quantify, non-invasively, tissue and molecular structures; the movement and behaviour of cells; and the delivery patterns of administered imaging dyes and nanoparticles in mouse models and reconstructed tissues. This will enable researchers to obtain anatomical, functional, physiological and molecular data simultaneously and in real-time, with resolution down to 40 micrometres. This will translate into both user efficiency and laboratory cost effectiveness, but more significantly is expected to result in greater understanding of fundamental mechanisms regulating the body's cell and tissue functions.Read moreRead less
Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk ass ....Closing the data gap: High throughput screening of nanoparticle toxicity. The nanotechnology sector is experiencing an exponential growth period with over 100 products containing manufactured nanoparticles entering the market every year. Ensuring growth of the sector needs to be balanced against the imperative of protecting both human and environmental safety. This project aims to develop new methodological and conceptual avenues to close the gap between innovation in nanotechnology and risk assessment. This is intended to be achieved by developing and validating high-throughput in vitro toxicity screening platforms for manufactured nanoparticles. The approach is based on advanced lab-on-a-chip microfluidic technologies. The predictive power of the platform will be refined and optimised via ex-vivo and in-vivo models.Read moreRead less
Photoelectrocatalysis-based Techniques for Bactericidal Applications. Effective control of the quality of water supply is paramount for public health. This project aims to develop a novel photoelectrocatalysis (PEC) based bactericidal technology capable of instant inactivation and rapid decomposition of waterborne pathogens in recycled water. The PEC processes at the illuminated semiconductor photoanodes with ultraviolet (UV) and visible light activities will be innovatively utilised with the ai ....Photoelectrocatalysis-based Techniques for Bactericidal Applications. Effective control of the quality of water supply is paramount for public health. This project aims to develop a novel photoelectrocatalysis (PEC) based bactericidal technology capable of instant inactivation and rapid decomposition of waterborne pathogens in recycled water. The PEC processes at the illuminated semiconductor photoanodes with ultraviolet (UV) and visible light activities will be innovatively utilised with the aim of in-situ generation of stable di-halide radical anions, reactive oxygen species and photoholes as effectual bactericides to achieve instant inactivation and rapid decomposition of waterborne pathogens. The success of the project is expected to provide Australian water industry with enabling technology to safeguard recycled water usage.Read moreRead less
Smart Nanocapsules for Efficient Cellular Delivery of Bioactive Peptide Drugs. This project will bring about practical benefits in terms of developing efficient therapeutic drug delivery systems, which has a market growth estimated to be ca. 23% p.a. in the world. The novel encapsulation technology developed in this project is not only desirable for biomolecules but also applicable for other functional materials and will find wide applications in a number of fields, such as chemical, food proces ....Smart Nanocapsules for Efficient Cellular Delivery of Bioactive Peptide Drugs. This project will bring about practical benefits in terms of developing efficient therapeutic drug delivery systems, which has a market growth estimated to be ca. 23% p.a. in the world. The novel encapsulation technology developed in this project is not only desirable for biomolecules but also applicable for other functional materials and will find wide applications in a number of fields, such as chemical, food processing and cosmetic industries. Successful completion of the project can also strengthen our capacity to participate in new areas of research and positioning Australia at the forefront of bionanotechnology.Read moreRead less
Developing innovative methodologies to understand nano-adhesion/friction. The project seeks to improve the measurement of nanoscale adhesion and friction. The understanding of adhesion and friction between a nanowhisker and a substrate is crucial for developing next-generation nanodevices. However, the current methods for measuring nanoscale adhesion and friction are inaccurate and can produce contradictory results, due to the extreme challenges in mastering sophisticated measuring techniques an ....Developing innovative methodologies to understand nano-adhesion/friction. The project seeks to improve the measurement of nanoscale adhesion and friction. The understanding of adhesion and friction between a nanowhisker and a substrate is crucial for developing next-generation nanodevices. However, the current methods for measuring nanoscale adhesion and friction are inaccurate and can produce contradictory results, due to the extreme challenges in mastering sophisticated measuring techniques and the lack of understanding of their underlying mechanisms. This project aims to develop innovative ‘push-peel’ and ‘push-slide’ methods to accurately measure those properties and to further understand their fundamental origins. Successful outcomes from this study would not only solve a long-standing problem in the application of nanowhiskers, but also generate new nanosurface science.Read moreRead less
Interactions between nanoparticles and bacteria. This project aims to understand how nanoparticles interfere with bacterial metabolism, and how these interactions lead to cell death, lysis and dispersal from biofilms. Intensive use of nanomaterials results in their continuously releases into the environment. While various nanoparticles have inhibitory and even toxic effects on microorganisms in ecosystems, the underlying mechanisms are not understood. This project will investigate model organism ....Interactions between nanoparticles and bacteria. This project aims to understand how nanoparticles interfere with bacterial metabolism, and how these interactions lead to cell death, lysis and dispersal from biofilms. Intensive use of nanomaterials results in their continuously releases into the environment. While various nanoparticles have inhibitory and even toxic effects on microorganisms in ecosystems, the underlying mechanisms are not understood. This project will investigate model organisms’ responses to nanoparticles at the cellular, enzymatic and gene expression levels. The findings are expected to help assess the immediate and long-term effect of nanoparticles on ecosystem health, for improved environmental management.Read moreRead less