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Nanosilver antimicrobial resistance in target pathogens. This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a bas ....Nanosilver antimicrobial resistance in target pathogens. This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a base template for novel nanosilver engineering with less tendency for resistance development and to facilitate tracking of resistance and its spread amongst microorganisms. The knowledge has far-reaching implications on the better governance of nanosilver use, including its disposal.Read moreRead less
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities ....Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities to address current limitations in understanding the stability of magnetic nanoparticles in biological fluids. The Australian partners will play a leading role in commercializing new applications for functionalized magnetic nanoparticles. The project will provide an excellent multidisciplinary research environment and training for early career researchers.Read moreRead less
Nano-scale tuning: a path to functional materials for hydrogen storage. If the nano-stores discovered can be taken from bench to markets, the way energy is produced and used will be revolutionised. New markets based on clean energy technologies will appear. The emergence of miniaturised hydrogen stores would create unforeseen markets. By utilising Australia's abundant resources in lithium (Li), magnesium (Mg) and aluminium (Al) to store hydrogen, the beneficiaries would be the Australian industr ....Nano-scale tuning: a path to functional materials for hydrogen storage. If the nano-stores discovered can be taken from bench to markets, the way energy is produced and used will be revolutionised. New markets based on clean energy technologies will appear. The emergence of miniaturised hydrogen stores would create unforeseen markets. By utilising Australia's abundant resources in lithium (Li), magnesium (Mg) and aluminium (Al) to store hydrogen, the beneficiaries would be the Australian industry and academia interested in the knowledge gained and the application of the unique features of nano-hydride materials. By reducing the emissions of greenhouse gases, society would also benefit from a cleaner environment and better health.Read moreRead less
Wet-Spinning Novel Multi-Functional Bio-Synthetic Platforms. The project will deliver new advanced materials for novel biomedical devices such as nanostructured electrodes and tunable drug delivery systems. It will develop a very versatile and low-cost technology that is well-suited for overcoming some of the current limitations in exploiting nanomaterials in nanoscience and biomedical industries. The research will benefit existing biomedical industries in Australia and provide opportunities for ....Wet-Spinning Novel Multi-Functional Bio-Synthetic Platforms. The project will deliver new advanced materials for novel biomedical devices such as nanostructured electrodes and tunable drug delivery systems. It will develop a very versatile and low-cost technology that is well-suited for overcoming some of the current limitations in exploiting nanomaterials in nanoscience and biomedical industries. The research will benefit existing biomedical industries in Australia and provide opportunities for new start-up companies, as well as potentially attracting biomedical industries from overseas to establish a presence in Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100517
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Development of hybrid carbon nanotube yarn and processing methods to create 3D smart materials and devices. The project aims to create 'intelligent' textiles by developing novel electroactive yarns and demonstrating scaled up processing through adapted knitting, weaving and braiding techniques. By tailoring their structure these unique carbon nanotubes can be made to act as sensors or artificial muscles.
Discovery Early Career Researcher Award - Grant ID: DE180100810
Funder
Australian Research Council
Funding Amount
$343,450.00
Summary
Optical tweezers for bio-nanotechnologies. This project aims to develop a platform of diamond nanosensors and novel optical tweezers for probing cellular processes with single-molecule resolution, in vivo and over physiologically relevant time scales. In biomedicine, long-term imaging of single-molecules is beyond reach with existing bio-labels. The project combines the superior properties of nanodiamond biomarkers (brightness, stability, small size and non-toxicity), with new optical tweezers w ....Optical tweezers for bio-nanotechnologies. This project aims to develop a platform of diamond nanosensors and novel optical tweezers for probing cellular processes with single-molecule resolution, in vivo and over physiologically relevant time scales. In biomedicine, long-term imaging of single-molecules is beyond reach with existing bio-labels. The project combines the superior properties of nanodiamond biomarkers (brightness, stability, small size and non-toxicity), with new optical tweezers which exploit laser trapping of atoms to manipulate nanodiamonds in three-dimensional biological environments. By accessing smaller size and higher force regimes, the platform will improve bio-imaging and bio-manipulation techniques, and potentially advance pathogentracking and early detection of diseases.Read moreRead less
Quantification of airborne engineered nanoparticles: developing a scientific framework to inform their regulation and control. Despite the presence of airborne engineered nanoparticles in many commercial/research facilities, there are no established methods for their detection/characterisation. This work aims to develop a foundation for the quantitative assessment of airborne engineered nanoparticles, which is critical for controlling exposure and minimising health risks.
Plasmon nanobiosensor for whole blood analysis. The new method will be able to detect specific disease markers or to identify subtle differences in protein content in complex dense analytes such as blood and other body fluids, of practical utility in diagnostic and clinical situations. It will also be relevant in other areas such as medical diagnostics of viral diseases, and for unsolved environmental monitoring problems such as the presence of specific microorganisms in industrial waste. Owing ....Plasmon nanobiosensor for whole blood analysis. The new method will be able to detect specific disease markers or to identify subtle differences in protein content in complex dense analytes such as blood and other body fluids, of practical utility in diagnostic and clinical situations. It will also be relevant in other areas such as medical diagnostics of viral diseases, and for unsolved environmental monitoring problems such as the presence of specific microorganisms in industrial waste. Owing to their design simplicity and low cost of components, the devices developed in this program will lend themselves well to the development of new commercial technologies for Australia.Read moreRead less
Hierarchical assembly of graphene oxide nanoparticles as bionanointerface. This project aims to develop a state-of-the-art fabrication methodology to develop large area polymer/graphene hybrid nanoparticle patterns to precisely modulate cell guidance and regeneration by exogenous electrical stimulation. Polymers and graphene have emerged as the main contenders for the development of soft biocompatible platforms. However, their applicability has been limited due to difficulties in patterning and ....Hierarchical assembly of graphene oxide nanoparticles as bionanointerface. This project aims to develop a state-of-the-art fabrication methodology to develop large area polymer/graphene hybrid nanoparticle patterns to precisely modulate cell guidance and regeneration by exogenous electrical stimulation. Polymers and graphene have emerged as the main contenders for the development of soft biocompatible platforms. However, their applicability has been limited due to difficulties in patterning and their consequent integration under physiological conditions. This project will advance both fundamental and practical knowledge at the forefront of nanotechnology and cell biology, whilst providing training to the research community at the cutting edge of science. The project will also deliver intellectual property, which will position Australia at the forefront of bionanotechnology.Read moreRead less