Development of Acid Degradable Polymeric Nanoparticles for Intracellular and Tumour Site Selective Delivery of Drugs. There is an enormous need to develop effective anticancer drug delivery systems to reduce the social and economic impact of cancer. One of the most critical problems in tumour treatment is the lack of selective toxicity of anticancer drugs against tumour tissues. Our multidisciplinary team will aim to develop a novel polymer based system for tumour site-selective delivery of anti ....Development of Acid Degradable Polymeric Nanoparticles for Intracellular and Tumour Site Selective Delivery of Drugs. There is an enormous need to develop effective anticancer drug delivery systems to reduce the social and economic impact of cancer. One of the most critical problems in tumour treatment is the lack of selective toxicity of anticancer drugs against tumour tissues. Our multidisciplinary team will aim to develop a novel polymer based system for tumour site-selective delivery of anticancer drugs. Development of such advanced drug delivery systems will significantly enhance Australia`s power in biotechnology. Development and/or formation of strategies to improve the health quality of Australians, is an important anticipated outcome of this innovative project.Read moreRead less
Development and Evaluation of Well-Defined Polymer-RNA Conjugates as Improved Therapeutics. Gene-based drugs offer an enormous potential to treat a wide range of diseases including, but not limited to, AIDS, hepatitis, and cancer. However, effective delivery of these drugs in body is needed to convert their therapeutic potential to clinically applicable treatments. Our multidisciplinary team will aim to develop novel, polymer-gene hybrid materials for efficient delivery of gene based therapeuti ....Development and Evaluation of Well-Defined Polymer-RNA Conjugates as Improved Therapeutics. Gene-based drugs offer an enormous potential to treat a wide range of diseases including, but not limited to, AIDS, hepatitis, and cancer. However, effective delivery of these drugs in body is needed to convert their therapeutic potential to clinically applicable treatments. Our multidisciplinary team will aim to develop novel, polymer-gene hybrid materials for efficient delivery of gene based therapeutics. Development of such advanced drug delivery systems will significantly enhance Australia`s power in biotechnology. Development and/or formation of new materials and strategies to improve the health quality of Australians, is an important anticipated outcome of this innovative project. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989920
Funder
Australian Research Council
Funding Amount
$750,000.00
Summary
Microbial and Cellular Imaging and Analysis Facility. The Microbial and Cellular Imaging and Analysis Facility will rapidly establish itself as one of Australia's premier science facilities. It will provide the capacity to investigate the structure and molecular dynamics of viruses and microbial, human, animal and plant cells with unprecedented high resolution in both pure and applied research settings, guided by Australia's leading experts in many research strengths. This facility addresses a c ....Microbial and Cellular Imaging and Analysis Facility. The Microbial and Cellular Imaging and Analysis Facility will rapidly establish itself as one of Australia's premier science facilities. It will provide the capacity to investigate the structure and molecular dynamics of viruses and microbial, human, animal and plant cells with unprecedented high resolution in both pure and applied research settings, guided by Australia's leading experts in many research strengths. This facility addresses a current unmet need for scientists in this country and will provide cutting-edge technologies to Australian researchers so they can better detect, understand, and treat human, animal and plant diseases and the environmental impact of climate change.Read moreRead less
Digital Outsourcing in Architecture: Opportunities for Australian Firms or Perils for Australian Workforce? This research will help assess competitiveness and viability of different digital outsourcing practices in connection to the needs, the operative conditions and the products of the Australian building design sector. The information will give industry analysts a tool to identify the markets within which these arrangements are likely to spread or occur in the future, and take consequent corr ....Digital Outsourcing in Architecture: Opportunities for Australian Firms or Perils for Australian Workforce? This research will help assess competitiveness and viability of different digital outsourcing practices in connection to the needs, the operative conditions and the products of the Australian building design sector. The information will give industry analysts a tool to identify the markets within which these arrangements are likely to spread or occur in the future, and take consequent corrective or supportive action. The outcomes of this project will benefit Australia by forecasting changes in professional employment prospects, and by providing a framework to consider development scenarios for architectural educational and professional institutions, national research and development priorities, and international trade agreement agendas.Read moreRead less
Conserving native wildlife during urbanisation: the effectiveness of biodiversity-friendly urban design and construction practices. Urbanisation has many negative effects upon native wildlife and their habitats, but biodiversity-friendly urban design and construction practices may greatly reduce these impacts. This study will examine the effectiveness of such measures at sustaining wildlife at sites of urban development, and will therefore produce significant benefits for local residents and the ....Conserving native wildlife during urbanisation: the effectiveness of biodiversity-friendly urban design and construction practices. Urbanisation has many negative effects upon native wildlife and their habitats, but biodiversity-friendly urban design and construction practices may greatly reduce these impacts. This study will examine the effectiveness of such measures at sustaining wildlife at sites of urban development, and will therefore produce significant benefits for local residents and the broader Australian community. Healthy natural ecosystems in urban areas provide many services to the public, reduce the need for costly management, and improve the livelihood of residents living in greener environments. This study will enhance all these community benefits through a detailed examination of the effectiveness of biodiversity-friendly urban development measures.Read moreRead less
Management of Complex Assets Using Smart Information Systems. The aim is to develop an integrative framework and a smart system for holistic asset management in order to manage and optimise asset decisions vis-a-vis shifts in customer and market needs. It will develop an advanced conceptual framework, a dedicated smart system that is capable of handling uncertainty often associated with decision making in large complex operations. The benefits of this research are: a more competitive indusry wit ....Management of Complex Assets Using Smart Information Systems. The aim is to develop an integrative framework and a smart system for holistic asset management in order to manage and optimise asset decisions vis-a-vis shifts in customer and market needs. It will develop an advanced conceptual framework, a dedicated smart system that is capable of handling uncertainty often associated with decision making in large complex operations. The benefits of this research are: a more competitive indusry with focus on markets; a smart system to demonstrate business-based decision making and generally a much more sophisticated approach to asset management.Read moreRead less
The rise of empiricism and the attempt to produce a unified understanding of the world, 1680-1750. Empiricism is often regarded as the characterising feature of modern scientific method, and, in those approaches to psychology and the social and economic sciences that seek to model themselves on successful scientific practice in the physical and life sciences, it often acts as a model of good practice. The project examines the original form of empiricism and shows how it was able to directly enga ....The rise of empiricism and the attempt to produce a unified understanding of the world, 1680-1750. Empiricism is often regarded as the characterising feature of modern scientific method, and, in those approaches to psychology and the social and economic sciences that seek to model themselves on successful scientific practice in the physical and life sciences, it often acts as a model of good practice. The project examines the original form of empiricism and shows how it was able to directly engage questions of value in a novel and revealing way, and how its connection with 'hard' sciences was not merely to provide a methodological gloss on these, but went to the core of what scientific explanation consisted in.Read moreRead less
Tracing the origins of stress in the symbionts of reef-building corals. Symbiotic dinoflagellates of corals are critical to the world's major tropical reef ecosystems. Recent work in our laboratories and others has revealed that these algae are sensitive to a wide array of stresses (including climate change) and hence may be the ?Achilles Heel? of reef ecosystems. This project will identify the key genes and processes in these algae using expressed sequence tags and microarray technology. On th ....Tracing the origins of stress in the symbionts of reef-building corals. Symbiotic dinoflagellates of corals are critical to the world's major tropical reef ecosystems. Recent work in our laboratories and others has revealed that these algae are sensitive to a wide array of stresses (including climate change) and hence may be the ?Achilles Heel? of reef ecosystems. This project will identify the key genes and processes in these algae using expressed sequence tags and microarray technology. On this basis, the underlying molecular mechanisms of these stress responses and their genetic diversity will be studied in order to better understand the differential susceptibility of reef-building corals to bleaching.Read moreRead less
From tourist siren to technological beacon: analysing the industrial function of the Sydney Opera House thirty years after its completion. The research will show that public buildings provide fertile ground to plant industrial seeds; but to have an impact on the local economy, they must respond to specific structural conditions or be supported by political will. These findings will improve Australia's institutional understanding of the relationship between cost and investment in construction, an ....From tourist siren to technological beacon: analysing the industrial function of the Sydney Opera House thirty years after its completion. The research will show that public buildings provide fertile ground to plant industrial seeds; but to have an impact on the local economy, they must respond to specific structural conditions or be supported by political will. These findings will improve Australia's institutional understanding of the relationship between cost and investment in construction, and clarify that the evaluation of building productivity requires a long-term perspective. Government agencies should use institutional projects to define their public face but also to plan and implement industrial strategies. The research will help Australia maximise its creative and technological capability by understanding the factors conducive to innovation and its acceptance.Read moreRead less
Mathematics, the science of real structure: an Australian realist philosophy of mathematics. The project will strengthen the already strong Australian philosophical tradition of realism, extending it into philosophy of mathematics. It will develop a robust alternative to the nominalism, Platonism and idealism that dominate northern-hemisphere philosophizing about mathematics, an alternative that is in tune with how mathematicians really apply mathematics. Australian philosophy will thus be stren ....Mathematics, the science of real structure: an Australian realist philosophy of mathematics. The project will strengthen the already strong Australian philosophical tradition of realism, extending it into philosophy of mathematics. It will develop a robust alternative to the nominalism, Platonism and idealism that dominate northern-hemisphere philosophizing about mathematics, an alternative that is in tune with how mathematicians really apply mathematics. Australian philosophy will thus be strengthened in general, giving it a greater attractiveness to the many overseas visitors and students who already appreciate its unique strengths. The nature of the project will also lead to closer ties and interdisciplinary work between philosophers and mathematicians.
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