Insights Into The Epitranscriptome: Linking RNA Methylation And Intellectual Disability
Funder
National Health and Medical Research Council
Funding Amount
$426,878.00
Summary
The string of nucleotides in an RNA molecule can contain the information to make proteins or to regulate diverse biological processes. Chemical modifications can be added to certain nucleotides that impact the regulation, structure or function of RNA. Recently, mutations in enzymes that modify RNA have been found in patients with intellectual disability. This project focuses on identifying and characterising specific RNA modification sites in brain that when disrupted cause mental retardation.
Identification Of Epigenetic Regulators Of Lung Development
Funder
National Health and Medical Research Council
Funding Amount
$625,036.00
Summary
Adaptation to air breathing at birth is dependent on the generation of normal lung structure. Failure of lung formation and surfactant function results in respiratory failure at birth. Although progress has been made in identifying genes and pathways critical for lung function, the factors that control their expression, so called epigenetic factors, are not known. In this proposal, we will seek to identify these factors controlling lung formation.
Investigating The Role Of Novel Heterochromatin And Centromere Proteins In Chromosome Segregation
Funder
National Health and Medical Research Council
Funding Amount
$522,896.00
Summary
The equal division of genetic material during cell division is essential so that genetic material is not lost or gained. This process is controlled by a complex array of proteins that replicate the genome, maintain its structural integrity, and equally distribute one copy to each daughter cell. This research aims to study the functions of newly identified proteins required for this process in a single cell yeast model-system and in human and mouse cells.