Toward An Evidence-based Approach For Treating End-stage Knee Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
World-wide more than one million total knee replacements (TKR) will be performed for end-stage knee osteoarthritis in 2016 alone. With an ageing population, demand for this procedure will increase dramatically, placing burden on a constrained health system. Up to 25% of TKR recipients experience on going pain after surgery and are dissatisfied with TKR. My research seeks to improve efficiencies and equitability of this important surgical procedure and in doing so optimise patient outcomes
Improving Communication About Immunisation Through Social Sciences Research
Funder
National Health and Medical Research Council
Funding Amount
$415,219.00
Summary
Vaccination is one of the greatest public health acheivements of the last century. Yet new threats to vaccine programs arise as diseases become less visible. Waning public confidence in immunisation and specific vaccine scares continue to threaten programs globally. This research will help to improve our understanding of why people do and don't immunise and the role communication can play. It will develop and test novel interventions to address public concerns and assist health professionals in ....Vaccination is one of the greatest public health acheivements of the last century. Yet new threats to vaccine programs arise as diseases become less visible. Waning public confidence in immunisation and specific vaccine scares continue to threaten programs globally. This research will help to improve our understanding of why people do and don't immunise and the role communication can play. It will develop and test novel interventions to address public concerns and assist health professionals in the way they communicate vaccine risk and benefit.Read moreRead less
Neurodevelopmental Risk Factors For Depression From Childhood To Early Adulthood
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
To understand who is at risk for depression, we need to understand how both the environment and biological factors promote risk at specific times in the life cycle. This research project will examine such risk factors in different phases of life (from in utero to early adulthood) using a developmental framework. The results of this research will provide a clearer basis for the design of prevention strategies that target individuals, their families and/or broader environmental factors.
Novel Genetic And Environmental Modifiers Of The Risk Of Iron Overload-related Disease In HFE-associated Hereditary Haemochromatosis In Cohort Of Middle-aged Australians
Funder
National Health and Medical Research Council
Funding Amount
$451,716.00
Summary
People who carry mutations in the HFE gene are pre-disposed to body iron overload but not all of them developed subsequent disease. According to the investigators of the “HealthIron” study in Melbourne, only 28% of men and 1% of women with faulty HFE genes go on to develop disease. This study has recruited more than 1,000 people from the community, and will determine which environmental and genetic risk factors stop people with iron overload from getting symptoms of disease.
Allergies And Chronic Respiratory Diseases: Causes, Biological Pathways And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
Allergies and chronic respiratory diseases are major causes of illness and death in Australia. Worryingly there are still many gaps in knowledge on how best to prevent and manage these diseases. The proposed program will investigate these questions and provide evidence to guide health policy and clinical management. As this program is built on state-of the-art methods and technology, these original Australian findings will be of great importance internationally.
Using Epidemiological Methods To Investigate How Genetic, Environmental And Lifestyle Factors Influence Cancer Incidence And Cancer Survivorship; And Translation Into Cancer Prevention And Policy Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$421,747.00
Summary
This research program focuses on investigating genetic, environmental and lifestyle causes of cancer, preventing new cases of cancer, and improving outcomes after a cancer diagnosis, particularly for melanoma and gynaecological cancer, which carry a heavy burden in the Australian population. The research will also inform the best allocation of health system resources for cancer control, and ensure translation of research findings into cancer prevention, clinical practice and policy outcomes.
Goodness-of-fit Testing And Extensions Of Relative Risk Models
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
Information about the health consequences of exposure to causal factors is obtained from mathematical models of observed data. Relative risk models are recommended for observations over time on a cohort of subjects, but it is not known how best to assess the adequacy of such models or whether they can be applied to ordered outcomes or multiple measurements on the same individuals. These research aims to address those issues, and thereby to increase the practical usefulness of these models.
Optimising Primary Care Risk Profiling And Management Of Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$408,387.00
Summary
Dr Carrington's CDF will support her career progression in 4 areas of translational research: 1. Closing the gap in ATSI heart health – optimising management of heart disease in Central Australia 2. Supporting healthy regional communities - developing cost-effective risk reduction clinics 3. Coordinating the care of complex cardiac conditions – refining an electronic tool to optimise GP management 4. International heart health – develop an effective primary care model of risk reduction in Sub-Sa ....Dr Carrington's CDF will support her career progression in 4 areas of translational research: 1. Closing the gap in ATSI heart health – optimising management of heart disease in Central Australia 2. Supporting healthy regional communities - developing cost-effective risk reduction clinics 3. Coordinating the care of complex cardiac conditions – refining an electronic tool to optimise GP management 4. International heart health – develop an effective primary care model of risk reduction in Sub-Saharan AfricaRead moreRead less