Estimation Of Transient Increases In Bleeding Risk Associated With Physical Activity In Children With Haemophilia
Funder
National Health and Medical Research Council
Funding Amount
$102,143.00
Summary
Haemophilia A and B are genetic conditions which affect 1 in 7,000 males in Australia. These disorders cause frequent bleeding due to problems with the clotting factor in blood. Over the past decade there has been a move to administer clotting factor to children with haemophilia in order to prevent bleeds and the consequent damage to joints that occurs when bleeds occur in a joint. Participation in vigorous physical activity and sport is thought to increase the risk of bleeding. Because of this, ....Haemophilia A and B are genetic conditions which affect 1 in 7,000 males in Australia. These disorders cause frequent bleeding due to problems with the clotting factor in blood. Over the past decade there has been a move to administer clotting factor to children with haemophilia in order to prevent bleeds and the consequent damage to joints that occurs when bleeds occur in a joint. Participation in vigorous physical activity and sport is thought to increase the risk of bleeding. Because of this, children are often given clotting factor prior to playing sport. However clotting factor is extremely expensive. For example, a boy wanting to play tennis three times a week would require three injections of cIotting factor per week at a cost of approximately $250,000 a year. To date there is no good evidence about which physical activities are likely to increase the risk of bleeding. If this information was available clinicians would be able to optimise timing of administration of clotting factor so that it is administered prior to activities associated with high risk of bleeds. Another reason to quantify risk of bleeds associated with activity is to inform decisions about participation in physical activity. Every boy with haemophilia wants to know if he can play sport or ride a skateboard or jump on a trampoline. Informed decisions about participation require accurate estimates of risk. This study will use an innovative design to provide, for the first time, accurate estimates of the risk of bleeding associated with physical activity. This information will form the basis for clinical practice guidelines regarding participation in physical activity.Read moreRead less
Regulation Of Red Blood Cell And Platelet Formation By BHLH Proteins
Funder
National Health and Medical Research Council
Funding Amount
$422,600.00
Summary
Continuous production of normal blood cells by the bone marrow is a process critical to human life. Disruption of this process leads to diseases such as leukemia, aplastic anemia and myelodysplasia which have devastating consequences for affected patients. Pivotal to understanding these diseases is a knowledge of the regulation of normal blood production. Our laboratory works on a gene known as SCL that is critical for blood formation. We have recently shown that loss of SCL in adult bone marrow ....Continuous production of normal blood cells by the bone marrow is a process critical to human life. Disruption of this process leads to diseases such as leukemia, aplastic anemia and myelodysplasia which have devastating consequences for affected patients. Pivotal to understanding these diseases is a knowledge of the regulation of normal blood production. Our laboratory works on a gene known as SCL that is critical for blood formation. We have recently shown that loss of SCL in adult bone marrow leads to abnormalities in two types of blood cells, the red blood cells and the platelets. This grant will extend this important observation to understand how the production of these cells is altered and what is its consequence. Our studies will help clarify the basis of blood cell formation and may impact on how we diagnose and treat a wide variety of blood disorders.Read moreRead less
Factor XII Dependent Coagulation, Thrombin And Platelet Glycoprotein 1ba In Arterial Thrombosis And Bleeding Disorders
Funder
National Health and Medical Research Council
Funding Amount
$104,664.00
Summary
Clot formation is the key event underlying heart attacks and strokes. There is new data that Factor XII (FXII) can play an important role in clot formation-thrombosis. We aim to examine the role FXII plays in clot formation, in particular the role of FXII in thrombin generation, which is the central event of clot formation, and its interaction with platelet glycoprotein 1ba (another important molecule in thrombosis). New insights into clotting and new therapies can result from our research.