Development Of A Novel MicroRNA Mimic For Cancer Treatment
Funder
National Health and Medical Research Council
Funding Amount
$534,179.00
Summary
Liver cancer is a major health burden globally, with a very poor prognosis. New treatments are urgently needed. We have developed proof-of-concept data showing that a tiny RNA, called a microRNA, is a powerful inhibitor of liver cancer growth. We will use this grant application to further develop the microRNA with novel chemistry so that it can be readily translated into early phase clinical trials in the near future.
Plasma Lipid Profiling For Risk Assessment Of Unstable Coronary Artery Disease
Funder
National Health and Medical Research Council
Funding Amount
$512,316.00
Summary
Age, sex, smoking, blood pressure and cholesterol level are risk factors for the development of heart disease. Most adults belong to an intermediate-risk group in which the predictive power of current risk factors is low. Most heart attacks occur in this group. Consequently, many individuals at risk are not properly identified nor treated appropriately. We are developing a new test to accurately assess risk of a future heart attack that will address this deficiency in our health system.