Use Of Statistical And Mathematical Models To Investigate Infectious Disease Transmission Dynamics To Better Inform Control Measures In Hospitals And The Community
Funder
National Health and Medical Research Council
Funding Amount
$408,388.00
Summary
Globally tuberculosis infects over 9 million people yearly. In low incidence countries TB is re-emerging, with HIV, drug resistance and migration driving this. Australia needs to examine the transmission of TB within our country and The Asia-Pacific region. This proposal will quantify the risk for importation of highly drug resistant TB into Australia and assess the factors that lead to outbreaks. Models will be informative for Australian TB policy development and contribute to regional and glob ....Globally tuberculosis infects over 9 million people yearly. In low incidence countries TB is re-emerging, with HIV, drug resistance and migration driving this. Australia needs to examine the transmission of TB within our country and The Asia-Pacific region. This proposal will quantify the risk for importation of highly drug resistant TB into Australia and assess the factors that lead to outbreaks. Models will be informative for Australian TB policy development and contribute to regional and global efforts for TB control.Read moreRead less
Geelong Osteoporosis Study: Fracture Risk Prediction Based On Twenty Years Of Prospective Data.
Funder
National Health and Medical Research Council
Funding Amount
$1,107,758.00
Summary
In this population-based study we will generate evidence, both environmental and genetic, for defining fracture risk in Australian men and women. This will help identify individuals likely to sustain fragility fractures so that suitable therapies can be recommended. The data will be useful for developing prognostic models in both a clinical setting and for genetic screening programmes.
Predictors And Correlates Of Health-related Quality Of Life And Morbidity In Overweight/obese Adolescents: Cohort Study
Funder
National Health and Medical Research Council
Funding Amount
$512,525.00
Summary
There is now no doubting the size and long-term risks to health of the childhood obesity epidemic. However, very little research has examined at population level its immediate consequences for mental health and physical functioning, what pathways confer risk and protection for these consequences, and their likely healthcare consequences. This study will utilise an existing cohort of approximately 1500 Victorian adolescents followed since childhood to examine neglected aspects of the genesis and ....There is now no doubting the size and long-term risks to health of the childhood obesity epidemic. However, very little research has examined at population level its immediate consequences for mental health and physical functioning, what pathways confer risk and protection for these consequences, and their likely healthcare consequences. This study will utilise an existing cohort of approximately 1500 Victorian adolescents followed since childhood to examine neglected aspects of the genesis and impacts of overweight and obesity. The Health of Young Victorians Study was originally assembled in 1997 when the children were in Grades Prep-3. In addition to information on putative risk and protective factors for overweight-obesity and direct measures of height and weight, it is unique in having collected data on health-related quality of life (HRQoL) since children were first recruited during the early primary school years. Eight years after the first wave, the children will be adolescents in Grades 8-11. This third wave will retain a focus on HRQoL. Innovations include study of potential emotional, behavioural and physical consequences of childhood obesity that may in turn affect the natural history of obesity. This large, population-based longitudinal study will redress neglected aspects of child and adolescent overweight-obesity specifically identified in 2003 by the NH and MRC. As well as establishing whether a range of common problems are related to overweight-obesity, it will be able to shed light on mechanisms of adverse outcomes associated with adolescent overweight-obesity, and study protective factors predicting remitting overweight from childhood to adolescence that may inform preventive activities. The study will make an international contribution to knowledge about pathways, prevalence and preventive opportunities for child and adolescent overweight-obesity.Read moreRead less
The natural history of licit and illicit drug use in a population cohort of stimulant users. The simultaneous use of alcohol and stimulant drugs by young Australian adults is an emerging social and public health problem. This project provides urgently needed information about the causes and extent of this problem by studying patterns of drug use within a community sample of young adults over a five-year period.
Dynamic spatio-temporal approach to environmental health modelling. Maintenance and enhancement of environmental health (EH) is an important aspect of sustainable development (SD). There has been an increasing realisation that an appropriate modelling approach needs to be developed to measure and promote EH. However, a framework for the development of EH models to facilitate environmental management decision-making has not been attempted to date. This research aims to increase fundamental knowle ....Dynamic spatio-temporal approach to environmental health modelling. Maintenance and enhancement of environmental health (EH) is an important aspect of sustainable development (SD). There has been an increasing realisation that an appropriate modelling approach needs to be developed to measure and promote EH. However, a framework for the development of EH models to facilitate environmental management decision-making has not been attempted to date. This research aims to increase fundamental knowledge on the relationship between environmental exposures and community well-being, to develop a dynamic and systematic approach to EH modelling, and to assess implications of EH models in the planning of SD and environmental management.Read moreRead less
Development of Environmental Health Indicators in the Context of Sustainable Development. Protecting and promoting community well-being and population health is an essential aspect of sustainable development (SD). It is critical, therefore, to develop rigorous environmental health indicators (EHIs) to provide solid bases for the planning of SD and environmental management decision-making. However, a framework for the development of EHIs has not been attempted. This research aims to increase fun ....Development of Environmental Health Indicators in the Context of Sustainable Development. Protecting and promoting community well-being and population health is an essential aspect of sustainable development (SD). It is critical, therefore, to develop rigorous environmental health indicators (EHIs) to provide solid bases for the planning of SD and environmental management decision-making. However, a framework for the development of EHIs has not been attempted. This research aims to increase fundamental knowledge on the relationship between EHIs and SD, to identify a core and extended set of EHIs, and to assess implications of EHIs in the planning of SD and environmental management. A framework for identification and application of EHIs will be developed.Read moreRead less
Integrated and precautionary approach for assessing complex environmental health impacts. It is important to develop an innovative and systematic approach to the improvement of environmental health impact assessment for emerging complex environmental hazards. It has become increasingly apparent that traditional risk assessment methods are no longer suitable for assessing the health impact of emerging global environmental issues such as climate change and ecosystem degradation. The novelty of thi ....Integrated and precautionary approach for assessing complex environmental health impacts. It is important to develop an innovative and systematic approach to the improvement of environmental health impact assessment for emerging complex environmental hazards. It has become increasingly apparent that traditional risk assessment methods are no longer suitable for assessing the health impact of emerging global environmental issues such as climate change and ecosystem degradation. The novelty of this proposal lies in its intention to create fundamental knowledge on an integrated and precautionary approach for assessing complex and emerging environmental health risks by development of a conceptual framework for integrated environmental health impact assessment.Read moreRead less
Toward the effective surveillance of environmental health hazards for a sustainable society. It is important to maintain and enhance environmental health and community well-being from a sustainable development perspective. There has been an increasing realisation that an effective surveillance system needs to be developed to identify and manage environmental health hazards. The expected research outcomes of this project provide significant social benefits by contributing to the development of an ....Toward the effective surveillance of environmental health hazards for a sustainable society. It is important to maintain and enhance environmental health and community well-being from a sustainable development perspective. There has been an increasing realisation that an effective surveillance system needs to be developed to identify and manage environmental health hazards. The expected research outcomes of this project provide significant social benefits by contributing to the development of an effective surveillance system of emerging environmental health hazards for a sustainable society. The results of this project will also assist governments to formulate policies, guide actions and assess progress in the direction toward sustainable development.Read moreRead less
20 Year Study Of Skin Cancer In A Queensland Community
Funder
National Health and Medical Research Council
Funding Amount
$396,415.00
Summary
Skin cancers are by far the commonest cancers diagnosed in Australia. Even though it is known that sun exposure in excess causes skin cancers there are complexities about the causes, especially of basal cell carcinoma (BCC) -the major type of skin cancer- that are still not understood. Relative intensity of sun exposure and perhaps its timing with respect to age in life may well be critical factors. We aim to study these causes in very great detail by collating information that has been gathered ....Skin cancers are by far the commonest cancers diagnosed in Australia. Even though it is known that sun exposure in excess causes skin cancers there are complexities about the causes, especially of basal cell carcinoma (BCC) -the major type of skin cancer- that are still not understood. Relative intensity of sun exposure and perhaps its timing with respect to age in life may well be critical factors. We aim to study these causes in very great detail by collating information that has been gathered over a 20 year period in a community-based skin cancer study in Nambour, Qld as well as performing some laboratory tests on skin cancer tissue collected from participants. This 3-year project will enable the full realisation of the potential of this esource-20 years in the making- with its wealth of information for answering questions about skin cancer decelopment and preventability. It should finally provide us with a clearer rationale for 'prevention of skin cancer' than is currently available. In addition we shall assess the costs of treatment of skin cancer in general and for the individual, and how much preventive practices for skin cancer might save the health budget, by using the releavnt data collected from this community sample.Read moreRead less