Quantifying The Microbial Health Risks Of Expanded Alternative Water Use
Funder
National Health and Medical Research Council
Funding Amount
$305,496.00
Summary
Addressing current and future water shortages requires substitution of high quality drinking water with alternative water sources for an expanded range of purposes. However, potential adverse health effects must be avoided. This project measures health risks associated with a variety of alternative water sources and water use combinations. Project outputs will help determine appropriate requirements for water treatment and help refine guidelines to ensure that water use is safe.
A Study Of Factors That May Influence The Neurocognitive Health Of HIV+ Populations: For Better- Early Antiretroviral Therapy? For Worse- Cardiovascular Risk Factors And Disease?
Funder
National Health and Medical Research Council
Funding Amount
$362,123.00
Summary
Cognitive health is of primary importance to HIV affected communities. Recently high blood pressure and high cholesterol have been associated with poor cognitive performance in middle aged HIV+ patients. We plan to study whether HIV+ patients with cardiovascular risk factors have faster and more frequent cognitive decline than HIV+ and HIV- patients without these risk factors. In another study we plan to determine the potential benefits of early versus deferred HIV antiretroviral therapy upon ne ....Cognitive health is of primary importance to HIV affected communities. Recently high blood pressure and high cholesterol have been associated with poor cognitive performance in middle aged HIV+ patients. We plan to study whether HIV+ patients with cardiovascular risk factors have faster and more frequent cognitive decline than HIV+ and HIV- patients without these risk factors. In another study we plan to determine the potential benefits of early versus deferred HIV antiretroviral therapy upon neurocognitive performance.Read moreRead less
Clinical, Environmental And Genetic Factors And The Risk Of Oesophageal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$145,685.00
Summary
Oesophageal cancer is a rapidly fatal disease which is becoming more common in Australia, the United States and other industrialised nations. This study will examine the mechanisms leading to the development of oesophageal cancer and aims to measure the effects of genes and environment on the burden of cancer. Ultimately, this research will help target persons at highest risk so that screening, prevention and surveillance efforts can be directed more effectively.
Global Data Mapping And Evaluation Of Needs, Capacities And Benchmarks In Organ Donation And Transplantation: Informing Effective Local And International Health Policy To Better Meet The Needs Of Patients
Funder
National Health and Medical Research Council
Funding Amount
$318,575.00
Summary
Global shortages of donor organs limit the provision of reliable and equitable access to solid organ transplantation. As a result, many are excluded from waiting lists, others deteriorate whilst awaiting transplantation, and some seek to purchase the needed organ. Countries have a responsibility to provide transplantation services sufficient to meet population need. This project evaluates international data for key interventions that may impact on waitlisting, donation and transplant practices.
Monitoring cardiovascular risk is a major part of the clinical workload both in general practice and specialty areas, but it is an under-researched area, reflected in a general lack of evidence based guidelines. My research will evaluate how to optimise the monitoring of cardiovascular risk both before and after starting treatment. By maximising clinical benefits for patients and minimising unnecessary resource use, my research will benefit patients, clinicians and the community at large.
Investigating The Genetic Correlation Underlying The Developmental Origins Of Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
The prevalence of cardiovascular disease and diabetes is increasing and the financial burden on society is substantial. Research has shown a link between birth weight and increased risk of these diseases. Genetics may be involved as not all individuals born of suboptimal weight go on to develop disease. This research will identify genes that jointly affect birth weight and future risk of adult disease, leading to a better understanding of the biological relationship between the two.
Large-Scale Multi-Omic Analysis And Risk Prediction Of Complex Human Disease
Funder
National Health and Medical Research Council
Funding Amount
$321,414.00
Summary
A major aim of medicine is to prevent disease, which is often more successful and cost-effective than treating an already existing condition. Common diseases, such as autoimmune and cardiovascular diseases, have a predisposing genetic basis. We will conduct genetic analysis of large datasets of coeliac disease and cardiovascular disease to better identify individuals at increased risk and to better understand the underlying biological processes through which genetics act to affect one's risk.
Understanding Ethnic Differences In The Relationships Between Cardiovascular Risk Factors And Cardiovascular Disease In High Risk Populations
Funder
National Health and Medical Research Council
Funding Amount
$151,374.00
Summary
Cardiovascular disease (disease of the heart and blood vessels) is the leading cause of death world-wide. However, the burden of this disease is significantly greater in some populations, including Indigenous Australians and South Asians (Indians, Pakistanis or Bangladeshis). This project therefore aims to improve our understanding of CVD risk in these populations, and to develop better clinical assessment tools that will assist in the early detection and management of CVD in these individuals.
Neural Connectivity In Young People At High Risk Of Developing Psychosis
Funder
National Health and Medical Research Council
Funding Amount
$331,972.00
Summary
This project will investigate whether or not young people at high risk of developing psychosis show irregularities in the connections between different parts of their brain. It will also investigate whether information about a high-risk individual’s brain connectivity can be used to predict a) whether that person will make the transition to psychosis, and b) their clinical prognosis if they do become psychotic.