Amoxycillin For Persistent Nasal Discharge In Rural And Remote Aboriginal Children: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$226,738.00
Summary
Aboriginal children have the highest rates of acute and chronic respiratory diseases ever documented. While the underlying cause is socioeconomic disadvantage, the features of poverty that result in disease are not clear. Our current understanding of important risk factors like overcrowding, malnutrition and smoke exposure cannot completely explain the excessively high rates of disease seen in rural and remote Aboriginal communities. This randomised, double-blind, placebo-controlled clinical tri ....Aboriginal children have the highest rates of acute and chronic respiratory diseases ever documented. While the underlying cause is socioeconomic disadvantage, the features of poverty that result in disease are not clear. Our current understanding of important risk factors like overcrowding, malnutrition and smoke exposure cannot completely explain the excessively high rates of disease seen in rural and remote Aboriginal communities. This randomised, double-blind, placebo-controlled clinical trial will measure the impact of antibiotic treatment on persistent nasal discharge and rates of transmission of bacterial respiratory pathogens. An innovative study design will test the efficacy of twice daily doses of amoxycillin on newly developed clinical and bacteriological outcome measures. Both the investigators and the Aboriginal community have considerable experience in conducting this type of research and are committed to using a cooperative model of clinical research to reduce disease burden. Ongoing training of Aboriginal health workers in the principles of clinical epidemiology is an essential component of this process. This study will make an important contribution to the medical literature. Despite the deaths of around 10,000 children children from acute respiratory infections each day, very little is known about how antibiotics affect the transmission of some of the principal causative organisms. This project will greatly assist the development of appropriate antibiotic prescribing practices in high-risk populations.Read moreRead less
From Bench To Bedside: A New Treatment For Chronic Rhinosinusitis
Funder
National Health and Medical Research Council
Funding Amount
$2,360,520.00
Summary
My research focuses on diseases of the upper airways, in particular chronic relapsing infections and inflammation of the nose and sinus mucosa and on improving wound healing after surgery. My research is translational, aimed at defining new treatments for these diseases. I have invented novel products that improve wound healing after surgery and instruments that help surgeons perform their surgeries in a better and safer way.
A Novel Nitric Oxide-based Treatment For Recalcitrant Staphylococcus Aureus-associated Chronic Rhinosinusitis
Funder
National Health and Medical Research Council
Funding Amount
$541,377.00
Summary
Chronic rhinosinusitis (CRS) is a common condition affecting the lives of up to 16% of the population. With yet no cure, the search for effective means of therapy is crucial. Patients with severe disease are most often found to have infection with the bacteria Staphylococcus aureus, associated with more severe symptoms and reduced quality of life. This study will investigate the effectiveness of a novel topical liposome-encapsulated nitric oxide in the treatment of this burdensome disease.