Statistical Analyses Of Whole Genome Genotype Data To Better Understand Psychiatric Disorders
Funder
National Health and Medical Research Council
Funding Amount
$543,755.00
Summary
Until now, determining an overlapping genetic aetiology between disorders, required large study cohorts of family records. Here we will use genome-wide genotypes available on independent case-control samples to estimate a shared genetic aetiology directly from the molecular data. In this way we will explore previously intractable questions, such as the relationship between rheumatoid arthritis in people with schizophrenia, a well-recognised epidemiological puzzle.
How Are Periodontal Disease And Rheumatoid Arthritis Inter-related?
Funder
National Health and Medical Research Council
Funding Amount
$563,262.00
Summary
Periodontal (gum) disease and rheumatoid arthritis are two of the most common chronic inflammatory diseases affecting humans. These two diseases have remarkably similar patterns of tissue destruction. It is possible that chronic periodontitis may prime or predispose susceptible individuals to developing rheumatoid arthritis. Treatment of periodontal disease may help reduce the severity of rheumatoid arthritis.
Understanding The Development Of Autoimmunity In Response To Citrullinated Peptide Antigen Presentation To T Cells In Rheumatoid Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$1,181,793.00
Summary
Rheumatoid arthritis (RA) is a systemic autoimmune disease predominantly affecting synovial joints, in 1% of adults worldwide. HLA-class II genes underlie the major genetic susceptibility to RA. The programme of work brings together 7 investigators from 3 countries to determine how autoimmunity develops to self antigens in individuals at genetic risk of RA and why resistance alleles are protective against RA, in Caucasian, Asian and North American Native populations. We will provide a molecular
Human Fc Receptors In Antibody Mediated Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$640,824.00
Summary
A series of major Australian discoveries is leading to the development of therapies to treat major inflammatory diseases such as rheumatoid arthritis, lupus and similar autoimmune diseases where there is a significant unmet need for new therapies. A major molecule, caled Fc receptor was discoverd by the researchers who have now found new ways to prevent it activating inflammatory cells and therby preventi tissue destruction.
Inhibitors Of Class II HDACs In Inflammatory And Metabolic Disease
Funder
National Health and Medical Research Council
Funding Amount
$615,774.00
Summary
Inflammatory diseases such as arthritis and inflammatory bowel syndrome are major social and economic burdens on Australian communities. Obesity, diabetes and cardiovascular disease are also now widely viewed as inflammatory diseases. New specialised types of anti-inflammatory drugs are urgently needed to treat such diseases. This project proposes to create new classes of anti-inflammatory drugs by altering anti-cancer drugs called histone deacetylase inhibitors.