Determination Of Diagnostic Molecular Profiles For Intraduct Lesions Of The Breast.
Funder
National Health and Medical Research Council
Funding Amount
$308,400.00
Summary
Breast cancer originates in cells within breast ducts. The introduction of Breast Screening for breast cancer has led to a dramatic increase in the diagnosis of breast cancer which is confined to these ducts and has not spread to surrounding tissue. This is known as 'ductal carcinoma in situ' or DCIS. It is evident that DCIS is variable in its tendency to give rise to more advanced breast cancer. However, currently our ability to predict the potential agressiveness of a particular DCIS is limite ....Breast cancer originates in cells within breast ducts. The introduction of Breast Screening for breast cancer has led to a dramatic increase in the diagnosis of breast cancer which is confined to these ducts and has not spread to surrounding tissue. This is known as 'ductal carcinoma in situ' or DCIS. It is evident that DCIS is variable in its tendency to give rise to more advanced breast cancer. However, currently our ability to predict the potential agressiveness of a particular DCIS is limited. In this research we are proposing to develop new methods for evaluation of DCIS that will more accurately predict clinical behaviour. An important adjunct is to ensure that these methods can be practically applied in a routine diagnostic setting. Achievement of the aims of this project will assist treatment planning for patients diagnosed with DCIS. It will also provide important information about breast cancers diagnosed as a consequence of breast screening.Read moreRead less
Magnesium Sulphate In Women At Risk Of Preterm Birth For Fetal Neuroprotection - An Individual Patient Data Review
Funder
National Health and Medical Research Council
Funding Amount
$276,002.00
Summary
Infants born preterm are at high risk of dying and survivors have a higher risk of neurological problems. Evidence suggests that giving magnesium sulphate to women at risk of preterm birth prior to delivery reduces cerebral palsy in surviving children. It is unclear which women may benefit, what dose and when prior to birth should magnesium sulphate be given. This review will determine how individual women should be treated with magnesium to help protect the brain of a baby born too soon.
Alternatives To Homologous Blood Transfusion - Development Of Evidence- Based Decision Aids.
Funder
National Health and Medical Research Council
Funding Amount
$213,697.00
Summary
Transfusion of donor blood is the traditional means of treating blood loss resulting from injury or during surgery. Donor blood is in short supply and in the past there have been episodes of contamination by viruses that have led to hepatitis and AIDS. Consequently there is much interest in a range of techniques designed to reduce the need for transfusion of donor blood. One of the most popular is transfusion of patients' own blood (autologous transfusion). Despite the popularity of some of thes ....Transfusion of donor blood is the traditional means of treating blood loss resulting from injury or during surgery. Donor blood is in short supply and in the past there have been episodes of contamination by viruses that have led to hepatitis and AIDS. Consequently there is much interest in a range of techniques designed to reduce the need for transfusion of donor blood. One of the most popular is transfusion of patients' own blood (autologous transfusion). Despite the popularity of some of these techniques their true value is not really proven. They may be capable of diminishing the need for a transfusion of donor blood, but the long-term effects of this are not clear. In addition the preparation of autologous blood is a burden for overworked blood banks, and autologous blood may itself be associated with its own problems. The main aims of this study are to carry out reviews of the best quality trials of the various alternatives to transfusion of donor blood and to carry out surveys to find out what patients and doctors think. In a third phase of the project we will use the information gathered in the first two phases to design decision aids. These are comprehensive structured summaries of the available evidence to enable patients and their physicians to collaborate in making informed decisions that are likely to lead to the best outcomes for patients. The products of the research will be a number of reviews of 'best evidence' that appear in the International Cochrane Library, available to health professionals around the world. In addition, the decision aids, if successful, will be made available in a form that can be used by all Australian patients who are facing surgery that is likely to require a blood transfusion.Read moreRead less
Ongoing Prospective Audit Using High Quality Data And Database Linkage To Improve The Outcomes Of Macular Disease
Funder
National Health and Medical Research Council
Funding Amount
$843,237.00
Summary
FRB! is a national collaboration of retinal research centres that will collect data during the usual patient consultation. We will track the risks and benefits of the new treatments for macular disease which will inform the development of evidence based clinical management guidelines to assist the clinician to deliver the most appropriate treatment in the safest, most cost effective manner. We aim to support this with information from linked population health databases.