The Role Of Microglia In Early Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$665,582.00
Summary
Diabetic retinopathy is one of the most feared complications of diabetes. This project will examine the role that retinal immune cells called microglia have in causing early changes in the vasculature. We will examine whether diabetes changes the way neurons communicate with blood vessels, opening up a possible treatment target that could prevent the progression to more advanced disease.
Novel Retinal Architectural Vascular Signs And Risk Of Cardiovascular Disease: The AusDiab Study
Funder
National Health and Medical Research Council
Funding Amount
$754,254.00
Summary
Cardiovascular disease (CVD) and diabetes are major health problems. Identifying 'people at risk' is critical to design preventative strategies. We have developed new computer software to measure detailed characteristics of retinal vessels. By appling this system to predict CVD or diabetes in the AusDiab Study we aim to find 'the best combination of risk factors' to predict CVD and diabetes. This will open up the possibility of new risk assessment using a simple 'eye scan.'
Development Of A High Acuity, Diamond Retinal Prosthesis
Funder
National Health and Medical Research Council
Funding Amount
$1,010,214.00
Summary
Over recent years our team has developed a retinal implant to restore sight to people with certain types of blindness. With 256 independently controllable electrodes this device is among the most sophisticated in the world. We aim to conduct experiments to demonstrate that our device can provide improved better visual acuity than the world leaders with a view to developing a competitive commercial medical technology.
Self-destructing CRISPR-constructs For Targeted Genome Editing In The Retina.
Funder
National Health and Medical Research Council
Funding Amount
$679,926.00
Summary
Despite the identification of specific mutations causing many inherited retinal dystrophies, all of these conditions are currently untreatable. We have established gene-editing techniques and have developed a novel mouse model, which will serve as a robust platform for testing different techniques of gene editing in the retina. No other group in the world is known to be using this platform for gene editing and our work will expedite the clinical translation of this technology.
A Fibroin-based Prosthetic Bruch's Membrane For The Treatment Of Age-related Macular Degeneration
Funder
National Health and Medical Research Council
Funding Amount
$538,080.00
Summary
Our aim is to develop a new therapy for the treatment of patients with age-related macular degeneration (AMD), a leading cause of blindness in our ageing population. The novelty of our therapy resides in using a protein derived from silk fibers (fibroin), to rebuild a healthy barrier between the outermost layer of the retina and adjacent blood vessels. We expect that the findings from this study will eventually lead to better outcomes for patients with AMD.
Characterizing Novel Therapeutic Interventions In A New Model Of Focal Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$536,794.00
Summary
Focal retinopathies such as age-related macular degeneration pose an immense burden on our society, both socially and economically. We have recently developed an animal model that allows us to investigate for the first time, drugs and therapies that might be used to treat AMD both after its onset, and more significantly, in at-risk populations before onset of the disease.
Information Delivery from Segmented Textual Data Streams. This project will contribute to the advancement of ICT innovation in Australia by developing a robust, reusable language understanding engine. The technology will be tailored to web applications, in the form of a conceptually-aware web search engine capable of tracking cross-document dialogues and identifying the core semantic thread of the dialogue. It will place Australia at the forefront of next-generation language technology developme ....Information Delivery from Segmented Textual Data Streams. This project will contribute to the advancement of ICT innovation in Australia by developing a robust, reusable language understanding engine. The technology will be tailored to web applications, in the form of a conceptually-aware web search engine capable of tracking cross-document dialogues and identifying the core semantic thread of the dialogue. It will place Australia at the forefront of next-generation language technology development, with applications in areas including concept-based multi-document summarisation and email surveillance.Read moreRead less
A scalable and portable question-answering system. The current availability of large volumes of free text digitally stored demands the development of methodologies that can automatically find specific answers to user questions about this "unstructured" information. The goal of this project is to develop a scalable portable and domain-independent real-time natural-language question-answering system that explores the logical contents of the text. To achieve this we will fuse current approaches to ....A scalable and portable question-answering system. The current availability of large volumes of free text digitally stored demands the development of methodologies that can automatically find specific answers to user questions about this "unstructured" information. The goal of this project is to develop a scalable portable and domain-independent real-time natural-language question-answering system that explores the logical contents of the text. To achieve this we will fuse current approaches to question answering with approaches that look at the logical contents of the questions and answer candidates. A central part of the project will be the characterisation of the optimal logical forms, the determination of efficient methods to create and store sentence logical forms of potentially large volumes of text, and the treatment of difficult questions by incorporating summarisation and text generation techniques.Read moreRead less
Advanced Capture, Analysis and Compression of Facial Images. Facial image processing is an area of research that holds an important key to future advances in intelligent human-to-computer and human-to-human systems. This project will investigate and develop superior approaches to image capturing of human faces for subsequent analysis and compression. It aims to develop innovative techniques to detect, extract and recognise faces, as well as more efficient ways to compress facial image data. This ....Advanced Capture, Analysis and Compression of Facial Images. Facial image processing is an area of research that holds an important key to future advances in intelligent human-to-computer and human-to-human systems. This project will investigate and develop superior approaches to image capturing of human faces for subsequent analysis and compression. It aims to develop innovative techniques to detect, extract and recognise faces, as well as more efficient ways to compress facial image data. This project will provide advanced Australian technology with applications in some of the world's fastest growing markets, including crowd surveillance, computer user interface, videoconferencing, and multimedia systems.Read moreRead less
Robust speech recognition in realistic hostile environments. Australia leads the world in the adoption of speech recognition technology but sadly lags in the development of the fundamental advances in the area. This research will help propel Australia to the forefront of new innovations in speech recognition technology and contributions to fundamental science. Our project will provide an excellent training ground for graduate students and researchers, with the real possibility of significant com ....Robust speech recognition in realistic hostile environments. Australia leads the world in the adoption of speech recognition technology but sadly lags in the development of the fundamental advances in the area. This research will help propel Australia to the forefront of new innovations in speech recognition technology and contributions to fundamental science. Our project will provide an excellent training ground for graduate students and researchers, with the real possibility of significant commercial benefit to the nation. The deployment of our system in the community will greatly enhance the defence and police forces ability for surveillance and security, and will provide new assistive aids to improve the quality of life and safety for the elderly and disabled.Read moreRead less