Investigating MicroRNAs As Key Regulators In A Novel Communication Pathway Driving Retinal Degeneration.
Funder
National Health and Medical Research Council
Funding Amount
$1,189,692.00
Summary
Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. The absence of current therapies has resulted in a significant economic burden associated with this debilitating and irreversible disease. This project will investigate the therapeutic potential of the body's own natural delivery vehicles called extracellular vesicles (EV). Along with the molecular cargo contained in EVs we will harness this as a treatment to slow down the progression of AMD.
Improving Kidney Transplant Outcomes Using Normothermic Machine Perfusion
Funder
National Health and Medical Research Council
Funding Amount
$778,232.00
Summary
Kidneys donated for transplantation are at risk of damage that prevent the organ from working and reduce its lifespan. Normothermic machine perfusion is a device that can circulate oxygenated blood at normal body temperature through a donor kidney prior to transplantation. In doing so it is able to resuscitate the kidney and prevent injury. We will determine how machine perfusion achieves this remarkable effect and investigate new treatments for kidney injury.