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Genetic And Environmental Factors And Early Lung Problems Can Be Related To Allergy And Poor Lung Development In Preschool Age Children
Funder
National Health and Medical Research Council
Funding Amount
$122,032.00
Summary
This important new collaboration between the Murdoch ChildrenÍs Research Institute and Barwon Health explores the impact of early lung development on longer term respiratory health. It utilises a newly validated, accurate and safe technique to measure lung function in young babies and children. Data on environmental factors and lung function will help us explore the risk factors for the development of allergy, asthma and lung infections in early life.
A Prospective, Randomised, Double-blind Trial Of Extended- Versus Bolus-infusion ?-lactam Therapy In Infective Exacerbations Of Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$148,431.00
Summary
I am an infectious diseases physician focused on the most effective way to use antibiotics to treat infections. People with cystic fibrosis often get lung infections and the bacteria that causes this, Pseudomonas aeruginosa, can be difficult to treat. I will be investigating whether infusing antibiotics over a prolonged period of time is more effective than standard therapy in treatment of Pseudomonas aeruginosa lung infections in patients with cystic fibrosis.
Early Detection Of Pulmonary Exacerbation In Cystic Fibrosis Using Nocturnal Measurements Of Cough And Sleep
Funder
National Health and Medical Research Council
Funding Amount
$140,949.00
Summary
Cystic Fibrosis (CF), the most common lethal inherited disorder effecting Australians, is a medical success story, with survival increasing from 5 years in 1970 to 40 years now. However, lower respiratory tract infections remain the major problem in CF. This project will develop and test a simple, non-invasive device to detect early chest infections, allowing early treatment, improving quality of life and preventing lung scarring. Less hospitalisations will benefit both patients and hospitals.
Improving The Understanding And Management Of Children Hospitalised With Bronchiolitis In Northern Australia
Funder
National Health and Medical Research Council
Funding Amount
$69,506.00
Summary
Acute bronchiolitis remains one of the most common serious lower respiratory tract infections. Children can be treated effectively at home; however many require hospitalisation and current treatment is essentially supportive with oxygen and fluid therapy. In Indigenous settings where high colonisation of bacteria and burden of respiratory disease exist, antibiotics such as azithromcyin may provide clinical improvement in the short term outcomes for those children hospitalised with bronchiolitis.
Long Term Outcomes Following Early Infection And Inflammation In Cystic Fibrosis Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$75,006.00
Summary
This study involves the long-term follow up of birth cohort of 98 infants with cystic fibrosis, with the objectives of assessing the impact of lower airway infection and inflammation in infancy and early childhood on the development of CF lung disease over 20-25 years, and of describing the development of the lower airway microbiota in early CF lung disease and its relationship to clinical outcomes.
Advancing The Knowledge, Understanding And Management Of Respiratory Exacerbations In Children With Bronchiectasis
Funder
National Health and Medical Research Council
Funding Amount
$71,359.00
Summary
Bronchiectasis is a condition which causes significant morbidity, burden of disease and mortality in children as well as adults. Exacerbations in bronchiectasis influence the decline in lung function and quality of life for patients. Although the importance of treating exacerbations effectively is well accepted, there are no universally accepted guidelines for recognizing and managing an exacerbation of bronchiectasis in children. This study aims to fill this clinical and research gap.
Non-invasive Methods Of Measuring Work Of Breathing In Children
Funder
National Health and Medical Research Council
Funding Amount
$41,267.00
Summary
Sleep-disordered breathing such as obstructive sleep apnoea, is currently diagnosed if a child stops breathing more than once per hour. For children with asthma or cystic fibrosis, who may not stop breathing during the night, how hard their breathing muscles work can have a significant impact on their health. A non-invasive method of measuring respiratory effort, and incorporating this measurement into how sleep-disordered breathing is diagnosed, can revolutionize how sleep-disordered breathing ....Sleep-disordered breathing such as obstructive sleep apnoea, is currently diagnosed if a child stops breathing more than once per hour. For children with asthma or cystic fibrosis, who may not stop breathing during the night, how hard their breathing muscles work can have a significant impact on their health. A non-invasive method of measuring respiratory effort, and incorporating this measurement into how sleep-disordered breathing is diagnosed, can revolutionize how sleep-disordered breathing in children are managed world-wide.Read moreRead less
Chronic obstructive pulmonary disease (COPD) causes airway narrowing and lung destruction resulting in breathlessness and cough. Earlier detection of acute attacks of breathlessness may improve treatment, prevent progression and reduce risk of death. The forced oscillation technique can detect attacks earlier and is easy to perform. It will be used in this study for home monitoring with application of time series analyses to accurately detect change so that acute attacks can be treated earlier.
THE EFFECT OF LONG ACTING BRONCHODILATORS ON VENTILATION IN COPD
Funder
National Health and Medical Research Council
Funding Amount
$143,676.00
Summary
COPD is a common and important smoking-related lung disease. Well-established treatments with inhaled medications including long-acting bronchodilators have a proven clinical track record. However the physiological basis for their effects is still under investigation. This research examines some of the physiological changes in lung function and the response to long-acting bronchodilators in patients with COPD, and may help explain why some patients respond to therapy while others do not, leading ....COPD is a common and important smoking-related lung disease. Well-established treatments with inhaled medications including long-acting bronchodilators have a proven clinical track record. However the physiological basis for their effects is still under investigation. This research examines some of the physiological changes in lung function and the response to long-acting bronchodilators in patients with COPD, and may help explain why some patients respond to therapy while others do not, leading to more targeted therapeuticsRead moreRead less
Parasitic and viral infections involving the retina are serious eye conditions that are poorly understood and lack effective treatments. My PhD studies will focus on how human retinal cells fight infections caused by the Toxoplasma parasite, and dengue and Ebola viruses. The results of my investigations will inform the development of better treatments for these blinding eye diseases.