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Optimising bubble continuous positive airway pressure (CPAP) for preterm infants. Synchrotron imaging will be used to see how the lungs of newborns are aerated and move when they are supported by continuous positive airway pressure (CPAP) breathing support. This project will provide fundamental biological information that will contribute to refinement of devices to support breathing in babies.
Relaxin: molecular mechanisms of action in the reversal of fibrosis. Defects in relaxin and relaxin receptors are increasingly implicated as a cause of fibrosis which is associated with many disease processes. This study will examine the molecular mechanisms linking relaxin and fibrosis and will determine whether relaxin can be used to reverse the condition.
Relaxin action in the heart, kidney, lung and uterus: understanding fibrosis. Relaxin is a peptide hormone associated with pregnancy. We have recently generated a relaxin gene knockout mouse and exciting preliminary data show that without relaxin, non-pregnant mice develop signs of fibrosis in the heart, lung and uterus. Combining our expertise in molecular biology, pharmacology and physiology, the overall objective of this project is to investigate the functions and mechanisms of relaxin action ....Relaxin action in the heart, kidney, lung and uterus: understanding fibrosis. Relaxin is a peptide hormone associated with pregnancy. We have recently generated a relaxin gene knockout mouse and exciting preliminary data show that without relaxin, non-pregnant mice develop signs of fibrosis in the heart, lung and uterus. Combining our expertise in molecular biology, pharmacology and physiology, the overall objective of this project is to investigate the functions and mechanisms of relaxin action in these organs. Our findings will provide important basic information on relaxin physiology and enable us to implement a long-term partnership with Connetics to understand how relaxin regulates collagen production and/or the development of fibrosis.Read moreRead less
Increasing the utility of tetanus toxins by protein engineering. There are a variety of common diseases that are the result of muscular defects. Some of these may be able to be treated with an agent that increases muscle tone, thereby giving benefit to the patient in the alleviation of symptoms. This project aims to use some of the most potent substances known, bacterial toxins, and engineer them to be valuable agents for treatment of certain muscular disorders.
Domestic air quality: towards the setting of guidelines. Air quality standards have been developed to protect human health. Although people spend most of their time indoors there are no standards and only a few guidelines for indoor air pollution (IAP). The aim of this study is to investigate the levels of IAP that may worsen asthma in children. Childhood asthma will be used as a health indicator due to its high prevalence, cost to the healthcare system and implications for respiratory morbidity ....Domestic air quality: towards the setting of guidelines. Air quality standards have been developed to protect human health. Although people spend most of their time indoors there are no standards and only a few guidelines for indoor air pollution (IAP). The aim of this study is to investigate the levels of IAP that may worsen asthma in children. Childhood asthma will be used as a health indicator due to its high prevalence, cost to the healthcare system and implications for respiratory morbidity in adult life. We expect to identify levels of IAP that will represent a health risk as well as the factors that may contribute to increased IAP in homes.Read moreRead less
X-ray Micro-tomography Validation of HRCT-Based Airway Measurements. This project brings together a newly emergent modality of microscopy in the form of 3D X-ray micro-tomography (XRMT) along with leading-edge image analysis to develop breakthrough science in respiratory research aimed at improving the reliability of high resolution computed tomography (HRCT). The project will develop novel 3D lung image segmentation protocols, a stereotactic registration program allowing 3D matching of XRCT and ....X-ray Micro-tomography Validation of HRCT-Based Airway Measurements. This project brings together a newly emergent modality of microscopy in the form of 3D X-ray micro-tomography (XRMT) along with leading-edge image analysis to develop breakthrough science in respiratory research aimed at improving the reliability of high resolution computed tomography (HRCT). The project will develop novel 3D lung image segmentation protocols, a stereotactic registration program allowing 3D matching of XRCT and HRCT data sets, and a validation protocol for quantitative HRCT analysis of airway disease. These outcomes will allow wider application of HRCT to non-invasively follow the dynamics of pulmonary function.Read moreRead less
Improving asthma device use: Innovative models for inter-professional practice. This project falls within the goals of National Priority 2: promoting and maintaining good health. This project has the potential to affect every individual accessing health care in the Australia. Through its approach to and focus on improving the use of asthma medications this project will impact on: the quality use of medicines and health outcomes for patients. Through its focus on health professional relationships ....Improving asthma device use: Innovative models for inter-professional practice. This project falls within the goals of National Priority 2: promoting and maintaining good health. This project has the potential to affect every individual accessing health care in the Australia. Through its approach to and focus on improving the use of asthma medications this project will impact on: the quality use of medicines and health outcomes for patients. Through its focus on health professional relationships and interdisciplinary approach to community health care it will result in: improved interprofessional relationships and a model of collaboration which has the potential to be implemented on a broad scale in the community.Read moreRead less
Advanced nanotechnologies for targeting biofilms. Advanced nanotechnologies for targeting biofilms. This project aims to develop nano-particulate systems based on a single platform technology that can be delivered as an aerosol. The current lack of a suitable formulation and delivery system hinders the eradication of fungal and bacterial biofilms from surfaces. These new systems will have enhanced residency time, penetration properties and effectiveness in biofilms. This project intends to under ....Advanced nanotechnologies for targeting biofilms. Advanced nanotechnologies for targeting biofilms. This project aims to develop nano-particulate systems based on a single platform technology that can be delivered as an aerosol. The current lack of a suitable formulation and delivery system hinders the eradication of fungal and bacterial biofilms from surfaces. These new systems will have enhanced residency time, penetration properties and effectiveness in biofilms. This project intends to understand the properties that govern the formation and interactions in these systems, and develop in-vitro tools that the wider scientific community can use. The project expects to generate a single platform that can be used for the eradication of biofilms in numerous applications, from healthcare to agriculture.Read moreRead less
High Gravity Precipitation of Nanoparticles for Pulmonary Drug Delivery. This collaborative project aims to explore the huge market potential of drug delivery by inhalation aerosols using nanoparticles. It will apply cutting edge nanotechnology to develop new techniques using high gravity to synthesise particles of biomaterials suitable for inhalation. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. Successful developme ....High Gravity Precipitation of Nanoparticles for Pulmonary Drug Delivery. This collaborative project aims to explore the huge market potential of drug delivery by inhalation aerosols using nanoparticles. It will apply cutting edge nanotechnology to develop new techniques using high gravity to synthesise particles of biomaterials suitable for inhalation. Nanoparticles can penetrate deeper into the lung where they deposit and dissolve faster for enhanced therapeutic effects. Successful development of the technology will position both Australia and the industry partner to take a lead in the application of this novel technology in pharmaceutical aerosols, and provides better inhalation therapy to benefit patients.Read moreRead less
Electric field effects on cochlear tissues. The project aims to solve the underlying biology of how electricity flows through the cochlear tissues, where and how electrical stimulation excites the auditory neurons, and what the effects of sustained electrical stimulation are on the nerve fibre growth and function. The research aims to show how electric fields can be controlled in the cochlea, and how auditory nerve fibres are affected at the cellular and molecular level. The long-term aim is to ....Electric field effects on cochlear tissues. The project aims to solve the underlying biology of how electricity flows through the cochlear tissues, where and how electrical stimulation excites the auditory neurons, and what the effects of sustained electrical stimulation are on the nerve fibre growth and function. The research aims to show how electric fields can be controlled in the cochlea, and how auditory nerve fibres are affected at the cellular and molecular level. The long-term aim is to utilise these findings to improve the control of neuronal excitability, for development of interfaces with the nervous system.Read moreRead less