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A Randomised Controlled Trial Of Interventional Versus Conservative Treatment Of Primary Spontaneous Pneumothorax
Funder
National Health and Medical Research Council
Funding Amount
$412,315.00
Summary
Primary spontaneous pneumothorax (PSP) is a collapsed lung that occurs in otherwise healthy people without underlying lung disease. Current standard treatment is to insert a chest drain into the chest to remove the air around the collapsed lung so that the lung re-inflates rapidly ("interventional treatment"). We will determine whether doing nothing, i.e. letting the lung re-inflate slowly on its own over several weeks ("conservative treatment"), is just as good or even better for patients.
Targeting Cystic Fibrosis Using A Novel Inhalation Therapy
Funder
National Health and Medical Research Council
Funding Amount
$421,545.00
Summary
Currently treatments for cystic fibrosis infection are via oral, intravenous or lengthy inhalation processes. This can lead to significant side effects, consequent poor patient compliance, and limited therapeutic efficacy. We will develop and test a novel high-dose inhalation dry power device containing an antibiotics for the rapid treatment of infection in cystic fibrosis therapy.
Longitudinal Characterization Of Respiratory And Immune Development From Birth To Adulthood In The Perth Respiratory Birth Cohort
Funder
National Health and Medical Research Council
Funding Amount
$528,885.00
Summary
The Perth Respiratory Birth Cohort Study began in 1987 and has assessed 253 children before birth and at follow-up at 1, 6 & 12 months, and 6, 11 & 18 years of age. The study has resulted in 63 publications and achieved consistent international prominence. The proposed study of the cohort at 24 yrs aims to determine the respiratory and immunological status of the cohort as young adults. This follow-up is essential to determine how early risk factors affect respiratory outcome in young adults.
Improving Pleural Procedures: Image Analysis And Training.
Funder
National Health and Medical Research Council
Funding Amount
$94,468.00
Summary
Currently, there is little evidence to guide the treatment of pleural disease, with common mismanagement and frequent adverse events. This project will develop image analysis tools, a clinical pathway and training to assist and guide clinicians in managing pleural disease, improving the diagnostic yield of pleural procedures, while reducing complication rates. It will offer a novel contribution to this young but blossoming field of respiratory medicine, ultimately leading to improved care for pe ....Currently, there is little evidence to guide the treatment of pleural disease, with common mismanagement and frequent adverse events. This project will develop image analysis tools, a clinical pathway and training to assist and guide clinicians in managing pleural disease, improving the diagnostic yield of pleural procedures, while reducing complication rates. It will offer a novel contribution to this young but blossoming field of respiratory medicine, ultimately leading to improved care for people with pleural disease.Read moreRead less
Development Of An Effective Therapy For Cheyne-Stokes Breathing In Heart Failure.
Funder
National Health and Medical Research Council
Funding Amount
$604,030.00
Summary
During sleep, patients with heart failure often exhibit a cyclic pattern of breathing in which a period of regular breathing alternates with a period when breathing ceases. This breathing pattern is associated with increased mortality and reduced quality of life but to date no effective treatment for it exists. We have developed a method to calculate an exact level of carbon dioxide to stabilise breathing in each individual, offering the prospect of a better night’s sleep and a longer life.
Breathe Well: A Centre For Research Excellence In Chronic Respiratory Diseases And Lung Ageing
Funder
National Health and Medical Research Council
Funding Amount
$2,527,082.00
Summary
Our CRE is based on common respiratory conditions covering wide spectrum of ages and severity. We will investigate how to maintain optimal respiratory health, through innovative approaches to early detection, improved therapy and adherence. We have a strong multi-disciplinary team of collaborators and we will build capacity through post-doctoral fellowships to improve our structural balance and optimise translational outputs. Tasmania is an ideal community to host a strong CCRE.
Low Dose Computed Tomography (LDCT) To Diagnose Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$3,032,884.00
Summary
This study aims to examine strategies for improving the effectiveness of lung cancer screening for reducing lung cancer deaths, and reducing the burden of the disease in the community. We will test the use of CT screening combined with a package of diagnostic measures, including the US NLST criteria, to determine if lung cancer nodules can be reliably detected at an earlier stage. Our aim in early detection is to also improve the potential for effective treatment approaches and health outcomes.
Non-invasive Methods Of Measuring Work Of Breathing In Children
Funder
National Health and Medical Research Council
Funding Amount
$41,267.00
Summary
Sleep-disordered breathing such as obstructive sleep apnoea, is currently diagnosed if a child stops breathing more than once per hour. For children with asthma or cystic fibrosis, who may not stop breathing during the night, how hard their breathing muscles work can have a significant impact on their health. A non-invasive method of measuring respiratory effort, and incorporating this measurement into how sleep-disordered breathing is diagnosed, can revolutionize how sleep-disordered breathing ....Sleep-disordered breathing such as obstructive sleep apnoea, is currently diagnosed if a child stops breathing more than once per hour. For children with asthma or cystic fibrosis, who may not stop breathing during the night, how hard their breathing muscles work can have a significant impact on their health. A non-invasive method of measuring respiratory effort, and incorporating this measurement into how sleep-disordered breathing is diagnosed, can revolutionize how sleep-disordered breathing in children are managed world-wide.Read moreRead less
Improving Evidence-based Treatment Of Latent Tuberculosis Infection In Public-hospital Based Chest Clinics
Funder
National Health and Medical Research Council
Funding Amount
$176,250.00
Summary
The aim of this project is to implement an electronic decision support (EDS) tool for preventive tuberculosis treatment into clinical practice. Information needs of patients and physicians as well as practical concerns regarding the use of the EDS will be evaluated before performing pilot testing and evaluating the impact of the EDS tool on simulated doctor-patient interactions and clinical workflow.
Developing Lung Function Reference Ranges In Aboriginal Australians
Funder
National Health and Medical Research Council
Funding Amount
$875,382.00
Summary
Lung function in Aboriginal Australians may be up to 30% lower than that of the Caucasian population. Comparing a patient’s lung function result to normal is critical to help diagnose and manage lung diseases. There are no lung function normal ranges for Aboriginal Australians. Our study will measure lung function in healthy Aboriginal children and adults and develop Aboriginal specific reference values and thus help ensure the highest level of clinical care for Aboriginal patients.