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Genetic And Environmental Factors And Early Lung Problems Can Be Related To Allergy And Poor Lung Development In Preschool Age Children
Funder
National Health and Medical Research Council
Funding Amount
$122,032.00
Summary
This important new collaboration between the Murdoch ChildrenÍs Research Institute and Barwon Health explores the impact of early lung development on longer term respiratory health. It utilises a newly validated, accurate and safe technique to measure lung function in young babies and children. Data on environmental factors and lung function will help us explore the risk factors for the development of allergy, asthma and lung infections in early life.
Non-invasive Methods Of Measuring Work Of Breathing In Children
Funder
National Health and Medical Research Council
Funding Amount
$41,267.00
Summary
Sleep-disordered breathing such as obstructive sleep apnoea, is currently diagnosed if a child stops breathing more than once per hour. For children with asthma or cystic fibrosis, who may not stop breathing during the night, how hard their breathing muscles work can have a significant impact on their health. A non-invasive method of measuring respiratory effort, and incorporating this measurement into how sleep-disordered breathing is diagnosed, can revolutionize how sleep-disordered breathing ....Sleep-disordered breathing such as obstructive sleep apnoea, is currently diagnosed if a child stops breathing more than once per hour. For children with asthma or cystic fibrosis, who may not stop breathing during the night, how hard their breathing muscles work can have a significant impact on their health. A non-invasive method of measuring respiratory effort, and incorporating this measurement into how sleep-disordered breathing is diagnosed, can revolutionize how sleep-disordered breathing in children are managed world-wide.Read moreRead less
Chronic obstructive pulmonary disease (COPD) causes airway narrowing and lung destruction resulting in breathlessness and cough. Earlier detection of acute attacks of breathlessness may improve treatment, prevent progression and reduce risk of death. The forced oscillation technique can detect attacks earlier and is easy to perform. It will be used in this study for home monitoring with application of time series analyses to accurately detect change so that acute attacks can be treated earlier.
THE EFFECT OF LONG ACTING BRONCHODILATORS ON VENTILATION IN COPD
Funder
National Health and Medical Research Council
Funding Amount
$143,676.00
Summary
COPD is a common and important smoking-related lung disease. Well-established treatments with inhaled medications including long-acting bronchodilators have a proven clinical track record. However the physiological basis for their effects is still under investigation. This research examines some of the physiological changes in lung function and the response to long-acting bronchodilators in patients with COPD, and may help explain why some patients respond to therapy while others do not, leading ....COPD is a common and important smoking-related lung disease. Well-established treatments with inhaled medications including long-acting bronchodilators have a proven clinical track record. However the physiological basis for their effects is still under investigation. This research examines some of the physiological changes in lung function and the response to long-acting bronchodilators in patients with COPD, and may help explain why some patients respond to therapy while others do not, leading to more targeted therapeuticsRead moreRead less
Reference Values For Spirometry, Lung Volumes, Diffusing Capacity, And Fractional Exhaled Nitric Oxide In First Nations Australians
Funder
National Health and Medical Research Council
Funding Amount
$83,832.00
Summary
Reference values in lung function tests allow respiratory doctors to accurately interpret results in order to effectively diagnose, treat and manage respiratory disease. Currently, reference values do not exist for First Nations adults. I will recruit 600 healthy First Nations adults from communities in Queensland and the Northern Territory for several lung function tests. Data collected will be submitted to the Global Lung Function Initiative to be incorporated into future guidelines.
Sleep, Telomere Length And Cardiorespiratory Phenotype In 11-12 Year Old Children: Cross-sectional Australian National Population Based Study
Funder
National Health and Medical Research Council
Funding Amount
$84,800.00
Summary
Telomeres are special areas at the ends of our chromosomes that ‘protect’ our DNA as our body cells divide. With ageing, our telomeres slowly become shorter, but the rate at which this happens varies. My project will investigate the associations between poor sleep duration and quality, increased risk of cardiovascular diseases, poor respiratory health and increased vulnerability to viral infections to shorter telomere length.
Cervical Auscultation In The Diagnosis Of Aspiration In Children
Funder
National Health and Medical Research Council
Funding Amount
$96,183.00
Summary
Accurate assessment of aspiration risk is critical to prevent respiratory illness & recurrent hospitalisations in children.Current clinical tests have poor reliability in detecting aspiration.Cervical auscultation(CA) is a portable,low-cost instrumental technique that may improve the accuracy of clinical test.This research aims to determine accuracy & reliability of CA in detecting aspiration, compared to objective radiological evaluations.CA may improve aspiration detection & subsequently minim ....Accurate assessment of aspiration risk is critical to prevent respiratory illness & recurrent hospitalisations in children.Current clinical tests have poor reliability in detecting aspiration.Cervical auscultation(CA) is a portable,low-cost instrumental technique that may improve the accuracy of clinical test.This research aims to determine accuracy & reliability of CA in detecting aspiration, compared to objective radiological evaluations.CA may improve aspiration detection & subsequently minimise health system costs.Read moreRead less
Protracted Bacterial Bronchitis(PBB) In Children - Natural History, Innate Immunity And Obstructive Sleep Disorders
Funder
National Health and Medical Research Council
Funding Amount
$97,438.00
Summary
Recurrent episodes of prolonged wet cough in children, termed Protracted Bacterial Bronchitis (PBB), may cause long term lung damage. I am a paediatric respiratory and sleep subspecialist in training. Through our research we will investigate for abnormalities in the immune system of children with recurring episodes of PBB and follow these children over a 2 year period to determine whether they go on to develop lung scarring. We will also be looking for a link between PBB and obstructive sleep pr ....Recurrent episodes of prolonged wet cough in children, termed Protracted Bacterial Bronchitis (PBB), may cause long term lung damage. I am a paediatric respiratory and sleep subspecialist in training. Through our research we will investigate for abnormalities in the immune system of children with recurring episodes of PBB and follow these children over a 2 year period to determine whether they go on to develop lung scarring. We will also be looking for a link between PBB and obstructive sleep problems in children.Read moreRead less
Obesity Hypoventilation Syndrome And Neurocognitive Dysfunction
Funder
National Health and Medical Research Council
Funding Amount
$124,608.00
Summary
In this study, we will assess neurocognitive function in patients with obesity hypoventilation syndrome (OHS – too slow or too shallow breathing) using a battery of tests including driving simulation, before and after 3 months of positive airway pressure therapy (CPAP). This will assess if chronically raised carbon dioxide levels contribute to impaired thinking capacity in addition to low oxygen levels.
A Prospective, Randomised, Double-blind Trial Of Extended- Versus Bolus-infusion ?-lactam Therapy In Infective Exacerbations Of Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$148,431.00
Summary
I am an infectious diseases physician focused on the most effective way to use antibiotics to treat infections. People with cystic fibrosis often get lung infections and the bacteria that causes this, Pseudomonas aeruginosa, can be difficult to treat. I will be investigating whether infusing antibiotics over a prolonged period of time is more effective than standard therapy in treatment of Pseudomonas aeruginosa lung infections in patients with cystic fibrosis.