Synthetic, Molecular and Biological Studies on Novel Marine Metabolites Isolated from Great Barrier Reef Sponges. Whilst structurally remarkable marine natural products, generated via unprecedented biosynthetic pathways, continue to be isolated from organisms found on the Barrier Reef these substances remain largely unexploited in terms of both their potent biological and ecological properties. Efficient syntheses of two classes of marine metabolites will be undertaken to allow biological, biosy ....Synthetic, Molecular and Biological Studies on Novel Marine Metabolites Isolated from Great Barrier Reef Sponges. Whilst structurally remarkable marine natural products, generated via unprecedented biosynthetic pathways, continue to be isolated from organisms found on the Barrier Reef these substances remain largely unexploited in terms of both their potent biological and ecological properties. Efficient syntheses of two classes of marine metabolites will be undertaken to allow biological, biosynthetic and ecological evaluation of advanced intermediates and final products. Such evaluations will provide new insights into the therapeutic and ecological potential as well as the origins of these natural products. New agents for the management of marine ecosystems and the treatment of oncological and other diseases should emerge.Read moreRead less
Total Synthesis and Biological Evaluation of Australian Sponge Metabolites. The development of functional syntheses of Australian natural products and certain analogues of ecological and therapeutic significance will emerge. Such activities will lead to the identification and evaluation of molecular entities of value in managing marine environments, reduce the need for removal of organisms from marine environments both within and outside of Australia as well as helping maintain and enhance chemi ....Total Synthesis and Biological Evaluation of Australian Sponge Metabolites. The development of functional syntheses of Australian natural products and certain analogues of ecological and therapeutic significance will emerge. Such activities will lead to the identification and evaluation of molecular entities of value in managing marine environments, reduce the need for removal of organisms from marine environments both within and outside of Australia as well as helping maintain and enhance chemical synthesis capacity within the country. The proposed studies could lead to the identification of related natural products produced by organisms on the Great Barrier Reef and that may display even more potent activities and/or complementary ecological roles.Read moreRead less