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Cervical Auscultation In The Diagnosis Of Aspiration In Children
Funder
National Health and Medical Research Council
Funding Amount
$96,183.00
Summary
Accurate assessment of aspiration risk is critical to prevent respiratory illness & recurrent hospitalisations in children.Current clinical tests have poor reliability in detecting aspiration.Cervical auscultation(CA) is a portable,low-cost instrumental technique that may improve the accuracy of clinical test.This research aims to determine accuracy & reliability of CA in detecting aspiration, compared to objective radiological evaluations.CA may improve aspiration detection & subsequently minim ....Accurate assessment of aspiration risk is critical to prevent respiratory illness & recurrent hospitalisations in children.Current clinical tests have poor reliability in detecting aspiration.Cervical auscultation(CA) is a portable,low-cost instrumental technique that may improve the accuracy of clinical test.This research aims to determine accuracy & reliability of CA in detecting aspiration, compared to objective radiological evaluations.CA may improve aspiration detection & subsequently minimise health system costs.Read moreRead less
Predicting Intrapartum Fetal Compromise At Term Using The Fetal Cerebro-umbilical Ratio And Placental Growth Factor Levels
Funder
National Health and Medical Research Council
Funding Amount
$86,733.00
Summary
A lack of oxygen to a baby after the onset of labour (i.e. fetal distress) in an otherwise healthy pregnancy is one of the top three causes of death in singleton pregnancies after 37 weeks. Our previous research has shown that a late pregnancy ultrasound scan combined with a blood test from the mother measuring the levels of a placental hormone can potentially identify pregnancies at risk. We aim to assess the value of this screening test at a major tertiary hospital.
Genetic And Environmental Factors And Early Lung Problems Can Be Related To Allergy And Poor Lung Development In Preschool Age Children
Funder
National Health and Medical Research Council
Funding Amount
$122,032.00
Summary
This important new collaboration between the Murdoch ChildrenÍs Research Institute and Barwon Health explores the impact of early lung development on longer term respiratory health. It utilises a newly validated, accurate and safe technique to measure lung function in young babies and children. Data on environmental factors and lung function will help us explore the risk factors for the development of allergy, asthma and lung infections in early life.
Non-invasive Methods Of Measuring Work Of Breathing In Children
Funder
National Health and Medical Research Council
Funding Amount
$41,267.00
Summary
Sleep-disordered breathing such as obstructive sleep apnoea, is currently diagnosed if a child stops breathing more than once per hour. For children with asthma or cystic fibrosis, who may not stop breathing during the night, how hard their breathing muscles work can have a significant impact on their health. A non-invasive method of measuring respiratory effort, and incorporating this measurement into how sleep-disordered breathing is diagnosed, can revolutionize how sleep-disordered breathing ....Sleep-disordered breathing such as obstructive sleep apnoea, is currently diagnosed if a child stops breathing more than once per hour. For children with asthma or cystic fibrosis, who may not stop breathing during the night, how hard their breathing muscles work can have a significant impact on their health. A non-invasive method of measuring respiratory effort, and incorporating this measurement into how sleep-disordered breathing is diagnosed, can revolutionize how sleep-disordered breathing in children are managed world-wide.Read moreRead less
Chronic obstructive pulmonary disease (COPD) causes airway narrowing and lung destruction resulting in breathlessness and cough. Earlier detection of acute attacks of breathlessness may improve treatment, prevent progression and reduce risk of death. The forced oscillation technique can detect attacks earlier and is easy to perform. It will be used in this study for home monitoring with application of time series analyses to accurately detect change so that acute attacks can be treated earlier.
Investigating Role Of Insulin Resistance And Sympathetic Nervous System In Metabolic Features Of PCOS
Funder
National Health and Medical Research Council
Funding Amount
$150,468.00
Summary
PCOS affects 9-18% of Australian reproductive aged women. Whilst reproductive features are prominent, PCOS has major psychological and metabolic consequences. Emerging data implicate the involvement of the sympathetic nervous system in PCOS. The aim of this PhD is to investigate the role of the sympathetic nervous system in insulin resistance and other metabolic features of PCOS and determine whether modification of this system's activity will favorably influence the metabolic consequences assoc ....PCOS affects 9-18% of Australian reproductive aged women. Whilst reproductive features are prominent, PCOS has major psychological and metabolic consequences. Emerging data implicate the involvement of the sympathetic nervous system in PCOS. The aim of this PhD is to investigate the role of the sympathetic nervous system in insulin resistance and other metabolic features of PCOS and determine whether modification of this system's activity will favorably influence the metabolic consequences associated with PCOS.Read moreRead less
THE EFFECT OF LONG ACTING BRONCHODILATORS ON VENTILATION IN COPD
Funder
National Health and Medical Research Council
Funding Amount
$143,676.00
Summary
COPD is a common and important smoking-related lung disease. Well-established treatments with inhaled medications including long-acting bronchodilators have a proven clinical track record. However the physiological basis for their effects is still under investigation. This research examines some of the physiological changes in lung function and the response to long-acting bronchodilators in patients with COPD, and may help explain why some patients respond to therapy while others do not, leading ....COPD is a common and important smoking-related lung disease. Well-established treatments with inhaled medications including long-acting bronchodilators have a proven clinical track record. However the physiological basis for their effects is still under investigation. This research examines some of the physiological changes in lung function and the response to long-acting bronchodilators in patients with COPD, and may help explain why some patients respond to therapy while others do not, leading to more targeted therapeuticsRead moreRead less
Determinants And Impact Of Patient-Centred Health Outcomes In Psoriatic Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$84,069.00
Summary
Psoriatic arthritis is a chronic joint disease which is linked with the skin condition called psoriasis. People who have psoriatic arthritis can develop deformities in their joints and suffer from decreased quality of life. Psoriatic arthritis can present in a wide range of ways, but the reasons for this are not understood. This research aims to explain some of this variation and to predict which patients will develop more severe disease so treatment can be targeted to improve their outcome.
Sleep-disordered Breathing In Pregnancy-induced Hypertension And Preeclampsia: Maternal And Fetal Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$129,559.00
Summary
Our study aims to compare signs of sleep-disordered breathing (such as snoring and breathing pauses) in pregnant women affected by hypertension or preeclampsia to those with a healthy pregnancy, and to see if they respond differently to the breathing problems. To do this we will examine whether snoring and breathing pauses during sleep have an impact on the pregnant woman’s blood pressure and the unborn baby’s heart rate overnight, and scans will monitor whether the baby’s growth is affected.
Reference Values For Spirometry, Lung Volumes, Diffusing Capacity, And Fractional Exhaled Nitric Oxide In First Nations Australians
Funder
National Health and Medical Research Council
Funding Amount
$83,832.00
Summary
Reference values in lung function tests allow respiratory doctors to accurately interpret results in order to effectively diagnose, treat and manage respiratory disease. Currently, reference values do not exist for First Nations adults. I will recruit 600 healthy First Nations adults from communities in Queensland and the Northern Territory for several lung function tests. Data collected will be submitted to the Global Lung Function Initiative to be incorporated into future guidelines.