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Improving asthma device use: Innovative models for inter-professional practice. This project falls within the goals of National Priority 2: promoting and maintaining good health. This project has the potential to affect every individual accessing health care in the Australia. Through its approach to and focus on improving the use of asthma medications this project will impact on: the quality use of medicines and health outcomes for patients. Through its focus on health professional relationships ....Improving asthma device use: Innovative models for inter-professional practice. This project falls within the goals of National Priority 2: promoting and maintaining good health. This project has the potential to affect every individual accessing health care in the Australia. Through its approach to and focus on improving the use of asthma medications this project will impact on: the quality use of medicines and health outcomes for patients. Through its focus on health professional relationships and interdisciplinary approach to community health care it will result in: improved interprofessional relationships and a model of collaboration which has the potential to be implemented on a broad scale in the community.Read moreRead less
Cardiovascular and Respiratory Activity During Sleep Onset. Going to sleep requires that behavioural and physiological activities be modified. This is achieved by the integrated activity of sleep mechanisms and the circadian system. In this project we will investigate the nature of the regulatory control exerted by sleep mechanisms over respiration and cardiovascular activity at sleep onset, how sleep control interacts with circadian influence, and the nature of cardio-respiratory activity when ....Cardiovascular and Respiratory Activity During Sleep Onset. Going to sleep requires that behavioural and physiological activities be modified. This is achieved by the integrated activity of sleep mechanisms and the circadian system. In this project we will investigate the nature of the regulatory control exerted by sleep mechanisms over respiration and cardiovascular activity at sleep onset, how sleep control interacts with circadian influence, and the nature of cardio-respiratory activity when sleep control is removed at an arousal from sleep. It is anticipated that a better understanding of the regulatory control exerted by sleep over other systems will improve our understanding of sleep disorders.Read moreRead less
Respiratory and Cardiovascular Activation at Arousal from Sleep. An arousal from sleep, no matter how brief, is assciated with increased activity in the respiratory and cardiac systems. Under normal circumstances the response is considered adaptive. However, in disorders of sleep in which individuals arouse frequently and their sleep is fragmented, such as in Obstructive Sleep Apnea, the phenomenon has been linked to hypertension. While the clinical consequences of sleep fragmentation are now ap ....Respiratory and Cardiovascular Activation at Arousal from Sleep. An arousal from sleep, no matter how brief, is assciated with increased activity in the respiratory and cardiac systems. Under normal circumstances the response is considered adaptive. However, in disorders of sleep in which individuals arouse frequently and their sleep is fragmented, such as in Obstructive Sleep Apnea, the phenomenon has been linked to hypertension. While the clinical consequences of sleep fragmentation are now apparent, the mechanism that causes the increase in physiological activity at each arousal, is not known. The aim of this project will provide insight into the mechanism that produces the activation response and provide a basis for minimising the cardiac consequences of sleep disorders.Read moreRead less
Common synaptic inputs to human upper airway muscles. Changes in the activity of upper airway muscles at sleep onset contribute to the development of Obstructive Sleep Apnoea. The aim of this project is to investigate how the brain controls upper airway muscles during wakefulness and sleep and to identify the pathological processes that lead to the development of Obstructive Sleep Apnoea.
Age and Gender Related Changes in Motor Control of the Upper Airway Muscle Genioglossus During Sleep. Obstructive Sleep Apnoea (OSA) is the repetitive obstruction of the airway during sleep. Obstructions occur because muscles of the upper airway fail to keep the airway open during inspiration. The disorder is associated with cardiovascular disease and cognitive and behavioural impairment. The prevalence of the disorder increases in older adults, contributing to age-related health and behavioural ....Age and Gender Related Changes in Motor Control of the Upper Airway Muscle Genioglossus During Sleep. Obstructive Sleep Apnoea (OSA) is the repetitive obstruction of the airway during sleep. Obstructions occur because muscles of the upper airway fail to keep the airway open during inspiration. The disorder is associated with cardiovascular disease and cognitive and behavioural impairment. The prevalence of the disorder increases in older adults, contributing to age-related health and behavioural problems. However, age-related changes differ in men and women. We believe the high prevalence of OSA in older adults is due to age and gender related changes in the activity of muscles in the upper airway. We will study the behaviour of the upper airway muscle genioglossus during sleep in young, middle-aged and older men and women.Read moreRead less
Sleep and circadian influences on mood and Autonomic Nervous System control of the heart. Most biological and behavioural processes have a 24-hour oscillation in activity. A critical question is whether this oscillation is a consequence of the sleep-wake cycle or the circadian system (our internal biological clock). This project will investigate circadian influence over two biological systems that have important influences over behaviour, the Autonomic Nervous System (ANS) and the Behavioural Fa ....Sleep and circadian influences on mood and Autonomic Nervous System control of the heart. Most biological and behavioural processes have a 24-hour oscillation in activity. A critical question is whether this oscillation is a consequence of the sleep-wake cycle or the circadian system (our internal biological clock). This project will investigate circadian influence over two biological systems that have important influences over behaviour, the Autonomic Nervous System (ANS) and the Behavioural Facilitation System (BFS). Specifically, we will investigate the relationship between circadian control of the heart and the induction and quality of sleep, and the circadian influence on aspects of personality (neuroticism) and mood (Positive Affect) that are related to the BFS.Read moreRead less
Hemispheric asymmetry of motor and language representation: Effects of hand preference and mirror movements. The neuroscience community has recently exploited advances in brain imaging to understand cerebral representation of many cognitive functions. The proposed study will expand our knowledge of brain-behaviour relationships, another key area of cognitive neuroscience research. Its successful funding and completion will increase Australia's standing as a major contributor to world research ou ....Hemispheric asymmetry of motor and language representation: Effects of hand preference and mirror movements. The neuroscience community has recently exploited advances in brain imaging to understand cerebral representation of many cognitive functions. The proposed study will expand our knowledge of brain-behaviour relationships, another key area of cognitive neuroscience research. Its successful funding and completion will increase Australia's standing as a major contributor to world research outcomes in this innovative and important field, and place Australia at its forefront. The investigator's access to advanced brain imaging and to the unique population of individuals with mirror movements, combined with expertise and experience in neuropsychology and brain imaging, places the research in an internationally competitive position.Read moreRead less
Bottlenecks in the brain: a causal role for the frontal-parietal network in multitasking limitations. When considering the information processing demands of modern life (for example, hands-free mobile phone use and driving) it is crucial to understand the mechanisms that underlie the severe multitasking limitations experienced by healthy individuals and clinical groups. This project investigates the brain regions critical for such limits to concentration.
Can cognitive training increase the capacity of perceptual attention? There has been an explosion of interest in the potential cognitive benefits of “brain training”. But scientific evidence for the generalizability of such benefits is controversial. Training has been argued to influence such operations as working memory, decision-making and intelligence. Only limited work has examined if training affects perceptual attention, which is important for awareness and is impaired in normal ageing and ....Can cognitive training increase the capacity of perceptual attention? There has been an explosion of interest in the potential cognitive benefits of “brain training”. But scientific evidence for the generalizability of such benefits is controversial. Training has been argued to influence such operations as working memory, decision-making and intelligence. Only limited work has examined if training affects perceptual attention, which is important for awareness and is impaired in normal ageing and in many psychiatric and neurological disorders. The project examines whether perceptual attention can be trained, using a combination of behavioural measures, brain imaging and stimulation protocols, and computational modelling. The results will have important implications for psychological theories of attention.Read moreRead less
Normal and abnormal processes of social attention orienting. Human beings are capable of rapidly detecting the direction of another person's eye-gaze and shifting attention reflexively in that direction. This project will compare shifts of attention to non-social and social cues of direction to determine whether attentional shifts to gaze-direction are fast because humans are biologically hard-wired to respond to social cues of evolutionary significance (eyes) or because humans are well-practice ....Normal and abnormal processes of social attention orienting. Human beings are capable of rapidly detecting the direction of another person's eye-gaze and shifting attention reflexively in that direction. This project will compare shifts of attention to non-social and social cues of direction to determine whether attentional shifts to gaze-direction are fast because humans are biologically hard-wired to respond to social cues of evolutionary significance (eyes) or because humans are well-practiced at using a number of different signals for direction in their environment. Findings from this work will than be used to investigate whether a selective impairment of responding to gaze-direction contributes to the social impairments so characteristic of people with schizophrenia.
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