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I am a respiratory physician studying mechanisms of respiratory allergy and host defence against respiratory viruses. My research aims to develop new ways of treating airway inflammation in asthma and COPD.
Genetic And Environmental Factors And Early Lung Problems Can Be Related To Allergy And Poor Lung Development In Preschool Age Children
Funder
National Health and Medical Research Council
Funding Amount
$122,032.00
Summary
This important new collaboration between the Murdoch ChildrenÍs Research Institute and Barwon Health explores the impact of early lung development on longer term respiratory health. It utilises a newly validated, accurate and safe technique to measure lung function in young babies and children. Data on environmental factors and lung function will help us explore the risk factors for the development of allergy, asthma and lung infections in early life.
Longitudinal Characterization Of Respiratory And Immune Development From Birth To Adulthood In The Perth Respiratory Birth Cohort
Funder
National Health and Medical Research Council
Funding Amount
$528,885.00
Summary
The Perth Respiratory Birth Cohort Study began in 1987 and has assessed 253 children before birth and at follow-up at 1, 6 & 12 months, and 6, 11 & 18 years of age. The study has resulted in 63 publications and achieved consistent international prominence. The proposed study of the cohort at 24 yrs aims to determine the respiratory and immunological status of the cohort as young adults. This follow-up is essential to determine how early risk factors affect respiratory outcome in young adults.
Immunity To Colonising Bacteria Of The Respiratory Tract In Atopic And Non-atopic Children
Funder
National Health and Medical Research Council
Funding Amount
$246,478.00
Summary
Evidence that seemingly harmless and common bacterial infections have a role, in the development of allergic disease has been uncovered. The development of immune responses to these microbes will be studied in children with and without allergy to inhalant allergens.
Influence Of Early-life Viral Infection On Severity Of Murine Chronic Asthma And Acute Exacerbations
Funder
National Health and Medical Research Council
Funding Amount
$508,528.00
Summary
This project examines the relationship between certain childhood infections with respiratory viruses and the progression of asthma later in life. The experimental work will use mouse models of mild chronic asthma and of an acute exacerbation of the illness -- these unique models have been developed in the laboratories of the chief investigators. It will employ the most appropriate mouse models of infection by the relevant group of viruses. We expect to obtain new information about mechanisms of ....This project examines the relationship between certain childhood infections with respiratory viruses and the progression of asthma later in life. The experimental work will use mouse models of mild chronic asthma and of an acute exacerbation of the illness -- these unique models have been developed in the laboratories of the chief investigators. It will employ the most appropriate mouse models of infection by the relevant group of viruses. We expect to obtain new information about mechanisms of airway inflammation and airway hyper-reactivity, which are characteristic features of chronic asthma and of acute exacerbations. This could help to identify candidate signalling molecules and pathways that could be targeted by new treatments. The findings might also provide a basis for development of ways to modify the immune response after respiratory viral infection in childhood.Read moreRead less
Mechanisms Of Induction And Progression Of Childhood Asthma: Investigations In A Mouse Model
Funder
National Health and Medical Research Council
Funding Amount
$517,586.00
Summary
This project investigates how certain respiratory viral infections in very young children might predispose to developing asthma, and how inflammation in the airways in asthma might then worsen. The experimental work, which will use unique mouse models developed in the laboratories of the chief investigators, will focus on changes in genes that control the pattern of immune response to allergens and that regulate the progression of inflammation.
Rhinovirus impairs physiological and immunological lung development and causes exacerbation of allergic airways disease. Rhinovirus (RV) infections account for around 90 per cent of asthma exacerbations, yet the mechanisms behind this are unknown. This project will use mouse models to study the effects of early life RV infection and allergic sensitisation on respiratory and immunological development, with the expectation that early life RV infection disrupts anitgen presenting cell function.
Therapeutic Potential Of The IL-3-IL-5-GM-CSF Common Beta Receptor To Treat Upper And Lower Allergic Airway
Funder
National Health and Medical Research Council
Funding Amount
$150,442.00
Summary
This research aims to develop new treatments for allergic diseases such as asthma and allergic rhinitis, which remain significant public health problems in Australia. We will develop new therapies with the potential to completely suppress acute and chronic allergic disease targeting a common receptor protein that controls multiple facets of allergic inflammation. We will test antibodies intended to treat human asthma using a novel mouse strain expressing the human form of this receptor.
Studies On The Effects Of RSV Infection During Infancy On Aeroallergen-specific T-cell Immunity And Lung Function
Funder
National Health and Medical Research Council
Funding Amount
$130,475.00
Summary
Many infants who develop transient severe wheezing in association with respiratory infections, go on to develop asthma which can persist throughout childhood and some times into adult life. It is not known whether the respiratory infections are a direct cause of later asthma, or whether they simply function as flag which identifies children who have a genetic predisposition to wheeze e.g. because they have abnormally narrow airways. This project will compare the effects of respiratory infection ....Many infants who develop transient severe wheezing in association with respiratory infections, go on to develop asthma which can persist throughout childhood and some times into adult life. It is not known whether the respiratory infections are a direct cause of later asthma, or whether they simply function as flag which identifies children who have a genetic predisposition to wheeze e.g. because they have abnormally narrow airways. This project will compare the effects of respiratory infection in infants with the RSV virus, who contract the disease at different ages, and who have varying levels of genetic risk for respiratory allergies. In particular, it will examine the possibility that in certain cases, infection of genetically susceptible individuals during early infancy will boost the development of allergies to airborne environmental allergens (such as house dust mite) which are known to trigger asthma attacks in older children and adults.Read moreRead less