A Multi-setting Intervention To Reduce Sedentary Behaviour, Promote Physical Activity And Improve Childrens Health
Funder
National Health and Medical Research Council
Funding Amount
$860,343.00
Summary
Sedentary behaviours and physical inactivity play a major role in the rising prevalence of obesity among children in Australia. This intervention study will take place in the school and family settings which play a critical role in shaping children's health behaviours. The objective is to determine whether a 2-year behavioural intervention reduces sedentary behaviour and promotes physical activity and results in improved health among 8-9 year old children.
Many older people who fracture their hip do not recover to their previous level of function. This study will test whether it is possible to help recovery of function, particularly walking, after hip fracture by using different and more intensive physiotherapy treatment. The treatment will concentrate on exercise when standing, will be provided twice daily and will continue after the person with hip fracture has returned home. Four months after the hip fracture it is expected that walking ability ....Many older people who fracture their hip do not recover to their previous level of function. This study will test whether it is possible to help recovery of function, particularly walking, after hip fracture by using different and more intensive physiotherapy treatment. The treatment will concentrate on exercise when standing, will be provided twice daily and will continue after the person with hip fracture has returned home. Four months after the hip fracture it is expected that walking ability, strength and balance will be improved by the new treatment methods.Read moreRead less
Exercise Self-management To Improve Long-term Functioning And Prevent Falls After Hip Fracture.
Funder
National Health and Medical Research Council
Funding Amount
$848,478.00
Summary
Up to 20,000 older Australians suffer hip fractures each year. Many people don't fully recover. We have designed a self-management training program which incorporates individualised exercise prescription. This novel program is designed for people who have completed usual treatment and rehabilitation for hip fracture. We will conduct a well-designed randomised controlled trial to test the effects of this program on disability, falls and hospital readmissions and to assess its cost-effectiveness.
Functional Genomic Analysis Of The Role Of P53 In Early Embryo Death After Assisted Reproductive Technologies (ART).
Funder
National Health and Medical Research Council
Funding Amount
$227,036.00
Summary
Assisted reproductive technologies (ART, such as IVF and related techniques) are successful treatments for most forms of infertility. ART are expensive therapies and much of this cost is related to the relative inefficiency of the technology. Much of this is due to the high mortality of the resulting embryos. Typically, 45-80% of embryos produced by ART do not survive the first week. Consequently the chance of any individual embryo resulting in a successful birth is not high. There has been only ....Assisted reproductive technologies (ART, such as IVF and related techniques) are successful treatments for most forms of infertility. ART are expensive therapies and much of this cost is related to the relative inefficiency of the technology. Much of this is due to the high mortality of the resulting embryos. Typically, 45-80% of embryos produced by ART do not survive the first week. Consequently the chance of any individual embryo resulting in a successful birth is not high. There has been only modest increments in embryo survival in recent years. The low cahnce of individual embryos resulting in a baby means that: (1) generally several treatment cycles are required; (2) superovulation is used to maximise the number of embryos produced giving an accumulation of unwanted cryopreserved embryos; (3) more than one embryo is generally transferred resulting in a significant incidence of multiple pregancies. The high mortality of the early embryo seems to be a general feature of IVF but its causes and effectors are not known. It has recently been established that it largely occurs due to a form of cell 'suicide' known as apoptosis. This form of cell death has important normal functions: its activation allows for cells that are no longer required to be removed, allowing the remodelling of tissues and it also serves to remove cells that are irreversibly damaged. p53 is a protein that has the ability to 'sense' cell stress and damage and to direct the cell to undergo apoptosis if the stress is severe. This project will examine if ART cause increased expression of p53 and whether this elevation of p53 causes embryonic cell death. We will examine the factirs that control p53 expression in the embryo. using mice with mutations that stop the function of p53 and several of its regulatory proteins. Experiments will determine the susceptibility of embryos possessing these mutations and will therefore allow us to define the proteins causing apoptosis after ART.Read moreRead less
Sustainable Development Of Tropical Australia: R&D For Management Of Land, Water And Marine Resources
Funder
Fisheries Research and Development Corporation
Funding Amount
$25,085.00
Summary
In response to the need for sustainable development of tropical Australia, CSIRO (Divisions of Marine Research, Tropical Agriculture, and Land and Water) in collaboration with State and Territory Departments (Queensland, Northern Territory and Western Australia), and the Land and Water Resources Research and Development Corporation (LWRRDC) and Fisheries Research and Development Corporation (FRDC) are developing a project which aims to overcome the significant gaps that exist in current knowledg ....In response to the need for sustainable development of tropical Australia, CSIRO (Divisions of Marine Research, Tropical Agriculture, and Land and Water) in collaboration with State and Territory Departments (Queensland, Northern Territory and Western Australia), and the Land and Water Resources Research and Development Corporation (LWRRDC) and Fisheries Research and Development Corporation (FRDC) are developing a project which aims to overcome the significant gaps that exist in current knowledge relating to the impacts of catchments and their associated land uses on the coastal zone and to integrate current and new knowledge to underpin the development of negotiated approaches to multiple use management.
The project will by necessity require strong integration across a range of physical, chemical, biological, economic and social disciplines. The integration of scientific knowledge with a broad suite of innovative approaches to regional planning will allow new benchmarks that exceed current practice in natural resource management. As such, it is likely that the proposed project could serve as a model for future work and, in so doing, deliver significant benefits to both tropical Australia and the nation. Objectives: 1. Identify natural resources priority issues with stakeholders, and determine their management priority, R&D needs, and institutional and organisational capacity; 2. Identify and review existing natural resource management data, process understanding and information; 3. Examine and critically review opportunities for R&D to underpin improved natural resource management and identify potential obstacles and risks to R&D in natural resource management; 4. Specify R&D priorities to underpin improved natural resource management and options for implementation. Read moreRead less