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Genetic testing of IVF embryos promises to improve success but shows no effect of live-birth rates. Many embryos are mosaic: containing cells with correct and incorrect chromosome numbers. Current testing is an invasive biopsy which fails to diagnose how many cells are abnormal in the cells that develop into the baby. Here we will use imaging to determine the ratio of abnormal:normal cells resulting in a non-invasive diagnostic that will improve IVF success.
Mitochondrial donation in fertilised eggs is a possible therapy for avoiding mitochondrial DNA disease, but there are major safety concerns, such as mutant mitochondrial carryover. To address these concerns, we will develop two new methods to eliminate carryover risk, then translate our findings to human eggs. Also, we will determine if the mitochondrial donation procedure affects offspring health. Our findings will serve as a guide for adopting the technology.
UNDERSTANDING THE BENEFITS AND LIMITATIONS OF METAPHASE II SPINDLE TRANSFER
Funder
National Health and Medical Research Council
Funding Amount
$1,629,373.00
Summary
Mitochondrial DNA (mtDNA) diseases are transmitted from a mother's eggs to her children. However, the levels of affected mtDNA differ amongst her eggs. Consequently, a carrier would not know if the newborn child were to suffer from these diseases. Mitochondrial Donation offers couples the potential to have an unaffected child. We will undertake the most comprehensive study of mitochondrial donation using one of its associated approaches to determine if it produces healthy embryos and offspring.
Advancing Equitable And Non-discriminatory Access To Health Services For First Nations Peoples: A Multidisciplinary Queensland Human Rights Act Case Study
Funder
National Health and Medical Research Council
Funding Amount
$1,279,602.00
Summary
The objective of this innovative study is to apply a multidisciplinary, right to health lens to critically explore & bring to light Indigenous Australians' experiences of racial discrimination in accessing equitable, quality & timely health services in urban, rural & remote locations. Research outcomes will be synthesised into a suite of project deliverables, with Multi-Stakeholder Advisory Group guidance & community co-design, to advance inter-generational health justice.
Improving Understandings Of And Responses To Alcohol-related Family Violence For Aboriginal People
Funder
National Health and Medical Research Council
Funding Amount
$1,294,735.00
Summary
Family violence and alcohol misuse contribute to many health and social inequities facing Aboriginal peoples. This Aboriginal-led project will investigate associations between alcohol and family violence in urban, regional and remote contexts to co-design improved interventions for Aboriginal peoples facing these issues. We will use an innovative approach combining participatory anthropological methods with network analytical techniques to address the gravity and complexity of the problem.
PRECIS: PRecision Evidence For Childhood Obesity Prevention InterventionS
Funder
National Health and Medical Research Council
Funding Amount
$1,280,254.00
Summary
This project will bring together global knowledge on community-based obesity prevention to identify the most effective and equitable approaches to create healthier communities. The project will support communities to create positive actions that are tailored to their own community characteristics and resources, to prevent childhood obesity now and into the future.
AKction2: Aboriginal Kidney Care Together - Improving Outcomes Now
Funder
National Health and Medical Research Council
Funding Amount
$1,950,173.00
Summary
This project brings together Aboriginal kidney patients and families, health professionals, health services, academics and researchers. Aboriginal peoples' lived experience of kidney disease and kidney care will inform and co-create improvements in care at an interpersonal, service and systems level. Patient journey mapping, effective collaboration between patients and clinical staff, and embedding Indigenous governance mechanisms will be used to improve both clinical and cultural safety.
Leaving No-one Behind: Informing Indigenous Aged Care Policy With Big Data.
Funder
National Health and Medical Research Council
Funding Amount
$1,668,851.00
Summary
Very little is known about older Indigenous people in aged care. Led by Indigenous people, this project will use a unique national dataset to answer questions on the experiences of Indigenous people in aged care, focusing on access and barriers to services and care, quality and safety of care and whether the care they receive meets their health needs. This research will inform service improvements and ensure older Indigenous people are not forgotten in much-needed aged care reforms.
Harnessing Information Technology To Improve Self-management Behaviours And Health Outcome In People With Heart Failure: A Smarthome Ecosystem Living Lab Study
Funder
National Health and Medical Research Council
Funding Amount
$1,120,226.00
Summary
The burden of heart failure in Australia is substantial. Management of heart failure is complex and requires self-management of symptoms and behaviour change, which requires ongoing education and support to achieve. Current approaches for supporting self-management do not meet the needs of people with heart failure or the healthcare system. This Australian first project aims to co-design an intelligent smart home ecosystem (Smart Heart) to support the management for people with heart failure.
Evidence For Action On Cold, Damp And Mould In Australian Homes
Funder
National Health and Medical Research Council
Funding Amount
$955,649.00
Summary
We know that living in cold and damp homes is bad for people's health. Surprisingly in Australia we do not know how much exposure to poor conditions and financial hardship combines to generate poor health at the population level. We will quantify this impact and estimate the benefit of interventions (such as mould removal and assistance for paying utility bills). This project will provide governments with evidence for tackling this housing-related health problem.