Exploring protease inhibitors in placental development and maturation. The placenta is essential for reproduction in many diverse species. This project aims to elucidate fundamental contributions of protease inhibitors and the proteases they target to placental development and maturation. It is expected to generate new knowledge around whether SPINTS play a fundamental role in disparate animals that independently derived a placenta, suggesting convergent genetic evolution. The project is expect ....Exploring protease inhibitors in placental development and maturation. The placenta is essential for reproduction in many diverse species. This project aims to elucidate fundamental contributions of protease inhibitors and the proteases they target to placental development and maturation. It is expected to generate new knowledge around whether SPINTS play a fundamental role in disparate animals that independently derived a placenta, suggesting convergent genetic evolution. The project is expected to result in disciplinary collaboration, produce novel models, and promote future projects in many species. The project should result in significant benefits toward advancing knowledge in reproductive biology, have economic and commercial benefits, and further enhance Australia's outstanding reputation in the field.Read moreRead less
Is SPINT1 a key regulator of placental development? . The placenta is an essential organ required for reproduction in placental species. This project aims to elucidate the fundamental biology of SPINT1 in placental development. It will generate new knowledge about whether the spatial and temporal expression of SPINT1 is conserved across several species; cow, sheep, lizard, mouse and human. It will also define the molecular mechanisms by which SPINT1 directs formation, maturation and expansion o ....Is SPINT1 a key regulator of placental development? . The placenta is an essential organ required for reproduction in placental species. This project aims to elucidate the fundamental biology of SPINT1 in placental development. It will generate new knowledge about whether the spatial and temporal expression of SPINT1 is conserved across several species; cow, sheep, lizard, mouse and human. It will also define the molecular mechanisms by which SPINT1 directs formation, maturation and expansion of the placental exchange interface which is critical for offspring survival.
The project will increase understanding of placental development, enhance collaboration and research knowhow, and promote future applied projects in all species that reproduce via placental support.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100375
Funder
Australian Research Council
Funding Amount
$428,191.00
Summary
Defining single-strand DNA break repair capacity in oocytes. This project aims to investigate fundamental biological mechanisms required for the production of high-quality oocytes, which fortify female fertility and the propagation of all sexually reproducing species. Exploiting unique mouse models, this study will define the importance of single strand DNA break repair capacity in oocytes for the first time, by outlining the role of single strand DNA repair proteins in maintaining genetic integ ....Defining single-strand DNA break repair capacity in oocytes. This project aims to investigate fundamental biological mechanisms required for the production of high-quality oocytes, which fortify female fertility and the propagation of all sexually reproducing species. Exploiting unique mouse models, this study will define the importance of single strand DNA break repair capacity in oocytes for the first time, by outlining the role of single strand DNA repair proteins in maintaining genetic integrity of gametes throughout their lifespan. In doing so, the intended outcome of this project is to dramatically improve our understanding of quality control in the female germ line. This should provide significant benefits to Australia by positioning it as a world leader in the field of Reproductive Science.Read moreRead less
DNA repair: a critical quality control mechanism in the female germ line. This project aims to investigate the fundamental biological mechanisms required for the production of high quality gametes, which underpin female fertility and the propagation of all sexually reproducing species. By taking advantage of unique mouse and avian models, this project expects to define the role of the DNA repair protein TOP3A in the successful completion of meiosis and it's requirement for the survival and genet ....DNA repair: a critical quality control mechanism in the female germ line. This project aims to investigate the fundamental biological mechanisms required for the production of high quality gametes, which underpin female fertility and the propagation of all sexually reproducing species. By taking advantage of unique mouse and avian models, this project expects to define the role of the DNA repair protein TOP3A in the successful completion of meiosis and it's requirement for the survival and genetic integrity of gametes throughout their lifespan. In doing so, the intended outcome of this project is to dramatically improve our understanding of quality control in the female germ line. This should provide significant benefits to Australia by positioning it as a world leader in the field of Reproductive Science.Read moreRead less