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Inhibition Of Specific NOX Isoforms As A New Treatment For Hypertensive And Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$855,172.00
Summary
Almost all people with diabetes will develop some retinal disease (diabetic retinopathy, DR) and vision loss. Unfortunately, current treatments target the late stages of DR, do not prevent disease progression and can be damaging. This project will uncover the role of a fundamental process that occurs in DR, called oxidative stress. We will evaluate a major cause of oxidative stress called NOX, which exists in various forms. Animal models of diabetes in which NOXes have been manipulated as well a