Catheter Based Renal Denervation To Improve Outcomes In Congestive Heart Failure
Funder
National Health and Medical Research Council
Funding Amount
$619,194.00
Summary
In heart failure there is a large increase in sympathetic nerve activity that is detrimental to patient outcome, but the factors causing this increased activity are not well defined. There is evidence that renal nerves play a significant role. A novel catheter based technique allows silencing of these nerves. We will test whether this novel technique has the potential to improve the outcomes for patients with heart failure.
Inadequately controlled blood pressure remains the leading cause of death world wide despite the availability of numerous effective drugs. We have successfully pioneered a catheter-based approach using radiofrequency-energy to disrupt renal nerves and lower blood pressure in patients with resistance to conventional drug treatment. We now aim to test the role of this ground-breaking technology as a potential cure (blood pressure control without antihypertensive medication) for hypertension.
Altered Renal Development Programs Adult Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$607,289.00
Summary
If a mother suffers an adverse condition during pregnancy - such as high blood pressure - the development of the baby is altered, putting it at increased risk of cardiovascular disease in adulthood. Our study in rabbits examine the role that changes to nerves in the kidney play in the development of high blood pressure later in life and whether it can be prevented via short-term anti-hypertensive treatment in the postnatal period .