Randomised Controlled Trial To Determine Efficacy And Safety Of Prescribed Water Intake To Prevent The Progression Of Autosomal Dominant Polycystic Kidney Disease (PREVENT-ADPKD)
Funder
National Health and Medical Research Council
Funding Amount
$746,751.00
Summary
Increasing the daily intake of water is well known to reduce the risk of developing kidney stones but there is growing evidence that it may also benefit other kidney diseases, particularly autosomal dominant polycystic kidney disease (ADPKD). This study will determine if adequate hydration can slow the progression of ADPKD, and could provide a relatively simple and cheap treatment for preventing the onset of kidney failure due to this disease.
CKD-FIX: A Randomised, Controlled Trial Of Allopurinol In The Slowing Of Kidney Disease Progression
Funder
National Health and Medical Research Council
Funding Amount
$1,917,147.00
Summary
Chronic kidney disease (CKD) is a major public health problem affecting over 1.5 million Australians and is associated with increased risk of death, heart disease and progression to end-stage kidney disease (ESKD). Current treatments to slow progression to ESKD are limited. The CKD-FIX trial aims to find out whether treatment with allopurinol, a commonly used drug for gout prevention, safely and effectively slows CKD progression. This could lead to significant health and economic benefits.
Stress During Pregnancy And The Developmental Origins Of Renal Disease In Aboriginal Australians
Funder
National Health and Medical Research Council
Funding Amount
$866,044.00
Summary
There is an epidemic of renal failure in Aboriginal people who also have high rates of premature birth of small babies. This project aims to understand the causes of kidney failure in Aboriginal people through testing if stress during pregnancy leads to the birth of preterm, small babies with small poorly formed kidneys that lead to kidney failure in later life. The effect of stressors impacting on pregnant women including infections, exposure to smoking and social stressors will be examined.
Understanding The Origins Of Diabetes And Kidney Disease In Aboriginal Children And Their Mothers
Funder
National Health and Medical Research Council
Funding Amount
$1,784,613.00
Summary
Aboriginal people experience increased rates of diabetes and kidney disease than non-Aboriginal Australians. This project seeks to understand the role played by the intrauterine events, maternal nutrition, breastfeeding and early growth in the development of diabetes and kidney failure in both Aboriginal mothers and their children.
Wellbeing Intervention For Chronic Kidney Disease (WICKD): A Trial Of The Aboriginal And Islander Mental Health Initiative (AIMhi) Stay Strong App.
Funder
National Health and Medical Research Council
Funding Amount
$1,031,562.00
Summary
Kidney disease is 10 times higher for Indigenous compared to non-Indigenous Australians. Treatment involves many losses (time, functioning, role and disconnection from family and country). This study is the first to explore effectiveness of a culturally adapted electronic mental health intervention – The AIMhi Stay Strong App for improving wellbeing, quality of life and treatment adherence for Indigenous patients on haemodialysis. Cost effectiveness of the intervention is also assessed.
Vascular And Neurogenic Determinants Of Hypertension In Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$508,142.00
Summary
You are as old as your arteries, and people with kidney disease have arteries that age fast. They also have overactive sympathetic nerves, and it is not clear if the blood vessels or nerves are responsible for the high blood pressure that puts strain on the heart and other organs of these patients. We will use an animal model to determine if therapy for hypertension reduces the stiffness of blood vessels or elevated nerve activity. Our results will enable better treatments for kidney failure.
The Intrarenal Renin Angiotensin System (RAS) In Indigenous Women: An Early Indicator Of Renal Dysfunction In Women At Risk Of Pregnancy Complications
Funder
National Health and Medical Research Council
Funding Amount
$645,358.00
Summary
Indigenous women are twice as likely to have low birth weight babies compared to non-Indigenous women and 2.5 times as likely to develop preeclampsia, possibly because they have a much greater incidence of chronic kidney disease, predisposing them to these pregnancy outcomes. We have found a new, sensitive marker of early stage renal dysfunction in pregnancy that could be useful for detecting early stage renal disease and which is indicative of an increased risk of adverse pregnancy outcome.
Designing effective learning experiences: Investigating novice and expert teachers’ design processes. Quality teaching leads to quality learning outcomes for students. Primary school teachers are responsible for designing learning experiences for their students in an increasingly complex environment. This project will advance understanding by: characterising and identifying differences in how novice and expert teachers approach the design of learning experiences for their students; capturing exp ....Designing effective learning experiences: Investigating novice and expert teachers’ design processes. Quality teaching leads to quality learning outcomes for students. Primary school teachers are responsible for designing learning experiences for their students in an increasingly complex environment. This project will advance understanding by: characterising and identifying differences in how novice and expert teachers approach the design of learning experiences for their students; capturing expert design processes through practice examples; and investigating how expert practice examples stimulate novice teachers to design learning experiences. This new understanding of teachers' design processes is necessary to enhance teacher preparation and continued professional learning.Read moreRead less
Early career teacher induction: Supporting precarious teachers. This project aims to investigate the ways in which Australian induction policies support precariously employed early career teachers to effectively manage student classroom behaviour. This project expects to generate new knowledge of workforce development and induction experiences of early career teachers employed on casual and short-term contracts. Expected outcomes of this project include alternative policy and practice recommenda ....Early career teacher induction: Supporting precarious teachers. This project aims to investigate the ways in which Australian induction policies support precariously employed early career teachers to effectively manage student classroom behaviour. This project expects to generate new knowledge of workforce development and induction experiences of early career teachers employed on casual and short-term contracts. Expected outcomes of this project include alternative policy and practice recommendations to support the transition of insecure replacement teachers within the profession. The benefits of this research include, improving teachers’ classroom management practices; the retention of new teachers; improving teacher workforce development; and building a healthier education system. Read moreRead less
Investigating the effectiveness of teacher education for early career teachers in diverse settings: a longitudinal study. This project investigates the effectiveness of teacher education programs in Victoria and Queensland in preparing teachers for the variety of school settings in which they begin their careers. The findings will inform state and national policy, as well as the work of professional regulation authorities and teacher education providers.