Long noncoding RNAs and their regulatory roles in epigenetic control of gene expression in plants. Epigenetic control of gene expression plays a critical role in development, environmental adaptation, stress response and disease resistance in plants, but its molecular basis remains largely unknown. The proposed study should contribute to the emerging field of epigenetics by discovering new regulatory noncoding RNAs involved in epigenetic mechanisms in plants. These new discoveries could potentia ....Long noncoding RNAs and their regulatory roles in epigenetic control of gene expression in plants. Epigenetic control of gene expression plays a critical role in development, environmental adaptation, stress response and disease resistance in plants, but its molecular basis remains largely unknown. The proposed study should contribute to the emerging field of epigenetics by discovering new regulatory noncoding RNAs involved in epigenetic mechanisms in plants. These new discoveries could potentially provide new opportunities and platforms for improving the performance, yield and quality of crop plants. The proposed study is therefore consistent with the national research priority goals such as breakthrough science, frontier technologies and promoting an innovation culture.Read moreRead less
Early evolution of the endomesoderm gene regulatory network. This project aims to unravel the endomesoderm gene network’s evolutionary history by identifying its conserved components’ target genes in the calcareous sponge Sycon. Little is known about the evolutionary origin of the developmental gene regulatory networks active in the development of all Eumetazoans (animals with nerves and digestive systems). Sponges are key models to study the transition from protists to eumetazoans, and gene exp ....Early evolution of the endomesoderm gene regulatory network. This project aims to unravel the endomesoderm gene network’s evolutionary history by identifying its conserved components’ target genes in the calcareous sponge Sycon. Little is known about the evolutionary origin of the developmental gene regulatory networks active in the development of all Eumetazoans (animals with nerves and digestive systems). Sponges are key models to study the transition from protists to eumetazoans, and gene expression data supports homology between sponge and eumetazoan tissues and body plans. This project could illuminate the evolutionary history of the animal body plan.Read moreRead less
Evolution and functional impact of gene silencing by hairpin derived RNAs. This project aims to study RNA-mediated gene silencing in genome evolution. RNA interference (RNAi) has been widely used as an experimental tool since its Nobel Prize-winning discovery in 1998, but little is known about endogenous RNAi or its evolution. This project uses bioinformatics, high-throughput sequencing and molecular approaches to study hpRNAs, a class of small interfering RNAs, their adaptive evolution across f ....Evolution and functional impact of gene silencing by hairpin derived RNAs. This project aims to study RNA-mediated gene silencing in genome evolution. RNA interference (RNAi) has been widely used as an experimental tool since its Nobel Prize-winning discovery in 1998, but little is known about endogenous RNAi or its evolution. This project uses bioinformatics, high-throughput sequencing and molecular approaches to study hpRNAs, a class of small interfering RNAs, their adaptive evolution across fly species and vertebrates, and their functional effect on testis morphogenesis and distortion of female/male sex-ratio. The project also studies splicing-dependent small RNAs and miRNA-target interaction. This research could have applications from animal development to human pathology.Read moreRead less
Changing your mind by changing your brain: An interventionist perspective on cognitive neuroscience. Functional neuroimaging provides a tremendous amount of information about the brain, but what it shows about the mind is less clear. Addressing this fundamental philosophical question requires developing a detailed account of theory-testing in cognitive neuroscience. This project aims to connect neuroimaging to theories of explanation that focus on the way one variable can make a difference to an ....Changing your mind by changing your brain: An interventionist perspective on cognitive neuroscience. Functional neuroimaging provides a tremendous amount of information about the brain, but what it shows about the mind is less clear. Addressing this fundamental philosophical question requires developing a detailed account of theory-testing in cognitive neuroscience. This project aims to connect neuroimaging to theories of explanation that focus on the way one variable can make a difference to another. By linking neuroimaging to facts about manipulable relationships between the brain and the mind, it will also provide a bridge between neuroimaging and complementary technologies for directly intervening on the brain. This, in turn, will provide a platform from which to explore the theoretical and ethical consequences of direct brain manipulation.Read moreRead less
The Language of Knowledge. Knowledge is central to our lives. The way we attribute knowledge to others governs whom we trust, how we reason, what we do, and whether we succeed. The significance of this project consists in a deeper understanding of our attributions of knowledge, situated within the context of questions. This project offers the benefits of quality foundational research in an interdisciplinary venue. It connects to a range of areas of National Research Priority including An Environ ....The Language of Knowledge. Knowledge is central to our lives. The way we attribute knowledge to others governs whom we trust, how we reason, what we do, and whether we succeed. The significance of this project consists in a deeper understanding of our attributions of knowledge, situated within the context of questions. This project offers the benefits of quality foundational research in an interdisciplinary venue. It connects to a range of areas of National Research Priority including An Environmentally Sustainable Australia, Promoting and Managing Good Health, and Frontier Technologies for Building and Transforming Australian Industries, insofar as all of these areas of National Research Priority are concerned with the acquisition and transfer of knowledge.Read moreRead less
Women, politics and democracy: political labour in India and Indonesia . This project aims to advance understandings of Asia's two largest democracies through an examination of the pathways and dead-ends to political power for women in India and Indonesia. Research of women's everyday political labour will examine their contributions to generating different forms of power, and their adverse incorporation into political structures. The comparative ethnographic approach will lead to the developme ....Women, politics and democracy: political labour in India and Indonesia . This project aims to advance understandings of Asia's two largest democracies through an examination of the pathways and dead-ends to political power for women in India and Indonesia. Research of women's everyday political labour will examine their contributions to generating different forms of power, and their adverse incorporation into political structures. The comparative ethnographic approach will lead to the development of analytical and conceptual tools to understand democracy across different socio-historical contexts. The project aims to produce policy and practice relevant knowledge to increase the meaningful participation of women in politics in India and Indonesia, with comparative lessons for other countries Read moreRead less
Local responses to missing persons and post-conflict peacebuilding . This project aims to fundamentally reshape dominant thinking on the problem of missing persons in post-conflict peacebuilding. Through the first large-scale comparative ethnography of Timor-Leste and Sri Lanka, the research will bring local community approaches, needs and practices around the missing in from the margins to the centre of scholarly analysis and practice. Outcomes include new knowledge about local agency and commu ....Local responses to missing persons and post-conflict peacebuilding . This project aims to fundamentally reshape dominant thinking on the problem of missing persons in post-conflict peacebuilding. Through the first large-scale comparative ethnography of Timor-Leste and Sri Lanka, the research will bring local community approaches, needs and practices around the missing in from the margins to the centre of scholarly analysis and practice. Outcomes include new knowledge about local agency and community understandings of the missing that are relevant to peacebuilding, and enhanced collaborations with scholars and policymakers. Expected benefits include improved international, state and NGO responses to missing persons to meet the needs of families and communities and facilitate sustainable peace after conflict.Read moreRead less
Transforming charity to reduce persistent poverty. This project aims to produce empirical knowledge to assist charities to reduce persistent poverty in Australia. In Australia people in poverty use charity to subsidise limited incomes and survive on a day-to-day basis. Recently charities are expected to assist in disrupting poverty in addition to poverty relief. However there is limited knowledge about how charities work with people who are poor and how they can change to work better. This proje ....Transforming charity to reduce persistent poverty. This project aims to produce empirical knowledge to assist charities to reduce persistent poverty in Australia. In Australia people in poverty use charity to subsidise limited incomes and survive on a day-to-day basis. Recently charities are expected to assist in disrupting poverty in addition to poverty relief. However there is limited knowledge about how charities work with people who are poor and how they can change to work better. This project expects to provide knowledge that governments, social service providers, and charities can use to transform their work with people in poverty. Read moreRead less
Control and learning for enhancing capabilities of quantum sensors. This project aims to develop new theories and algorithms to enhance capabilities in engineering quantum sensors from the perspective of systems and control. The project is significant because it is anticipated to advance key knowledge and provide systematic methods to enable achievement of high-precision sensing for wide applications, e.g., early disease detection, medical research, discovery of ore deposits and groundwater moni ....Control and learning for enhancing capabilities of quantum sensors. This project aims to develop new theories and algorithms to enhance capabilities in engineering quantum sensors from the perspective of systems and control. The project is significant because it is anticipated to advance key knowledge and provide systematic methods to enable achievement of high-precision sensing for wide applications, e.g., early disease detection, medical research, discovery of ore deposits and groundwater monitoring. The intended outcomes are fundamental theories, effective control and learning algorithms for achieving highly-sensitive sensors. These outcomes should make important contributions to and deliver new knowledge and skills for Australia's sensing industries, which could benefit Australia's economic growth.Read moreRead less
Evolution in a changing environment. Climate change is having dramatic effects on wild animal populations. This project will investigate how and why these effects occur, and whether populations will be able to evolve to adapt to a changing environment.