Genomic And Proteomic Profiling Of Dendritic Cell Heterogeneity
Funder
National Health and Medical Research Council
Funding Amount
$1,971,250.00
Summary
Dendritic cells (DC) present antigens to T cells and regulate immunity and tolerance. DC are heterogeneous, comprising seven functionally distinct subsets. We will use genomics and proteomics to identify the plasma membrane and endosomal proteins that underpin this functional heterogeneity. Such proteins are potential targets for improved protocols of vaccination and prevention of autoimmunity. This project will thus provide further opportunities for high-quality research and commercialisation.
The Role Of Toll Like Receptors In Leukocyte Activation And Adherence In Glomeruli In Auto-immune Glomerulonephritis
Funder
National Health and Medical Research Council
Funding Amount
$82,554.00
Summary
1 in 7 Australians have Kidney disease. Kidney disease tends to be progressive and over 8500 Australians require renal replacement therapy (dialysis). The cost of dialysis from 2004-2010 in Australia will be $ 4.5 billion. Auto-immune disease and Diabetes accounts for nearly 60% of kidney failure. Whilst current regimes exist to treat Kidney disease these are limited because they are deleterious side-effects. Improved understanding of the mechanism of disease will lead to improved treatments.
Deciphering How TCR Affinity Regulates CD4 T Cell Help In Immunity And Autoimmunity
Funder
National Health and Medical Research Council
Funding Amount
$850,885.00
Summary
Immune responses require the coordinated interaction and cross-talk between two types of white blood cells known as CD4 and CD8 T cells. A dysregulated interaction between these cells could be the cause of autoimmune and persistent infections by pathogens leading to chronic diseases. The aim of this proposal is to provide a deeper understanding of CD4/CD8 T cell interactions to improve immune outcomes in many chronic diseases in which interaction between these two immune cells is critical.
I am an cellular immunologist determining the mechanisms by which immunity to foreign organisms is generated, how tolerance to self tissues is maintained, and how the immune system iscriminates between foreign organisms and self.