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Reprogramming is the conversion of any cell into induced pluripotent stem cells (iPSC). iPSC carry immense clinical potential as they are pluripotent and can hence form any cell of the human body, however, they can also form tumours. We have identified a cell type during reprogramming which is pluripotent but cannot form tumours. It is the aim of this project to determine the molecular differences between iPSC and this cell type in order to facilitate the delivery of cell replacement therapies.
Dissecting The Cell Signalling Cues For Periodontal Regeneration
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
The project will first demonstrate that periodontal ligament cells have the ability to differentiate into osteoblasts (bone-forming cells) and cementoblasts (tooth root cementum-forming cells), which can be enhanced by the activation of signalling cues (Wnt/? catenin signalling). This will lead to the development of a novel material with cell signal enhancing properties, and present a new treatment option to repair and regenerate the three-dimensional structures of the tooth-supporting tissues.
NCE Based Strategy For Nuclear Reprogramming And Regenerative Medicine
Funder
National Health and Medical Research Council
Summary
Induced pluripotent stem cells (iPSCs) can be made by reprogramming adult cells. These cells can become any cell type in the human body. We can now create patient specific cells that may restore function in patients and not be rejected by their immune system. However, current methods for making iPSCs are slow, inefficient and have some safety concerns. This project aims to overcome these issues by using new chemical entities to reprogram cells that may be used for tissue repair and regeneration.
Characterising The Mechanisms That Control Blood Cell Development
Funder
National Health and Medical Research Council
Funding Amount
$335,616.00
Summary
Hematopoiesis is a tightly regulated process that provides the body with a constant supply of all the cells of the blood system. My studies aim to characterize the molecular mechanisms that regulate the expansion and differentiation of hematopoietic stem cells (HSCs) into each cell lineage. These studies will be key to the effective use of cellular transplantation therapeutic strategies and aim to provide a greater understanding of the mechanisms that underpin proliferative disorders such as can ....Hematopoiesis is a tightly regulated process that provides the body with a constant supply of all the cells of the blood system. My studies aim to characterize the molecular mechanisms that regulate the expansion and differentiation of hematopoietic stem cells (HSCs) into each cell lineage. These studies will be key to the effective use of cellular transplantation therapeutic strategies and aim to provide a greater understanding of the mechanisms that underpin proliferative disorders such as cancer.Read moreRead less
A Population Based Investigation Of Early Life Lung Development And Immune Programming
Funder
National Health and Medical Research Council
Funding Amount
$176,719.00
Summary
Asthma and allergic diseases cost Australia in excess of 7.8 billion per year. We are yet to identify any substantially effective preventative strategies. The applicant is a highly successful early stage clinician-researcher based in regional Victoria. This collaborative project will involve extending two existing NHMRC projects, in addition to establishing a new unselected Australian birth cohort, in to investigate the early life gene-environment determinants of asthma and allergic disease.
Optimising Transfusion Support In Critical Illness And Haematological Malignancies
Funder
National Health and Medical Research Council
Funding Amount
$262,251.00
Summary
Blood transfusion is commonly used for patient care. Improving our understanding about how to best use blood and blood products and finding ways to reduce the need for transfusion have been identified as important areas of national research. This fellowship aims to investigate interventions to reduce bleeding and the need for transfusion and improve the use of blood transfusion in two patients groups who are major users of blood: critically ill patients and patients with blood cancers.
Almost every member of clinical staff in hospitals now carries a smartphone or tablet. These devices can improve staff performance when life-saving information such as reminders of complex procedures during medical emergencies are delivered in a clear way. This fellowship applies design processes used in other high-risk industries such as in military and nuclear power settings to devise ‘e-aids’ for clinicians to improve outcomes in health emergencies.
Using The Results Of Genome Wide Association Studies To Reduce The Burden Of Disease: A Case For Type II Diabetes?
Funder
National Health and Medical Research Council
Funding Amount
$332,255.00
Summary
Only half of those with type II diabetes (T2D) have been diagnosed. The delay allows for the progression of associated problems like blindness, cardiovascular disease and heart failure. Advances in genetics have helped identify genes increasing the risk of T2D. Using this information, we see whether we can predict if someone will develop the disease. We then determine whether a test at birth followed by preventive measures reduces the problems associated with T2D and helps people live longer.