Myopia And Colour Vision: Potential Impact Of Colour Vision Gene Variation On Susceptibility To Myopia
Funder
National Health and Medical Research Council
Funding Amount
$227,947.00
Summary
The frequency of myopia has shown a rapid increase in recent years but the underlying cause remains largely unknown. Our recent work on severe myopia with dichromacy has indicated that some forms of myopia may arise through changes in cone visual pigments and the arrangement of cone photoreceptors in the retina which impact on the feedback loop between image formation and eye elongation. This study seeks to explore this link in detail in myopia patients that possess normal colour vision.
Optical And Neural Limits Of Visual Performance In Myopia
Funder
National Health and Medical Research Council
Funding Amount
$191,902.00
Summary
Short-sightedness (myopia) is one of our most common eye problems, affecting approximately 20% of people. It is usually due to the eye becoming too long for its power. While we can correct short-sight with contact lenses, spectacles and more recently refractive surgery, recent evidence shows that the vision of corrected myopes is poorer than that of people who have good distance vision without the need for an optical correction. This reduction is present even when the optical minification of spe ....Short-sightedness (myopia) is one of our most common eye problems, affecting approximately 20% of people. It is usually due to the eye becoming too long for its power. While we can correct short-sight with contact lenses, spectacles and more recently refractive surgery, recent evidence shows that the vision of corrected myopes is poorer than that of people who have good distance vision without the need for an optical correction. This reduction is present even when the optical minification of spectacle lenses is taken into account (the lenses used to correct short-sightedness make objects look smaller). It is possible that the anatomical changes to the eye that occur in short-sightedness are the cause of the reduced vision. Even if the optics can be fully corrected with refractive surgery, as is now being proposed, this may not result in excellent vision. The anatomical changes may occur in different parts of the eye and depending on where they occur the nature of the visual reduction will vary. The location of the retinal changes may also be important in terms of eventual pharmacological treatments for short-sightedness. In addition, the significance of the visual reduction, in terms of its effect on the functioning of short-sighted people, e.g. ability to perform under less than optimal visual conditions such as in the presence of glare or reduced light levels, is not known. We plan to investigate this by identifying the optical and neural contributions to visual performance in short-sighted people.Read moreRead less
Uncovering The Aetiology Of Myopia Through Identification Of Refraction And Ocular Biometric Genes
Funder
National Health and Medical Research Council
Funding Amount
$697,786.00
Summary
Myopia or short-sightedness affects 1 in 4 people in the Western world and is a major source of uncorrected vision loss, as well as blindness. This proposal aims to identify genes in myopia using a new technique called genome wide association. We will apply this technique to individuals collected through a population based Eye study to allow us to identify these genes. The outcomes of this work will allow us to identify high risk individuals as well as develop new measures to prevent myopia.
Age Related Changes In The Optics Of Adult Human Eyes
Funder
National Health and Medical Research Council
Funding Amount
$199,437.00
Summary
Vision is limited by both optical and retinal-neural factors. Our understanding of the optical structure of the human eye is limited, partcularly for the refractive index gradient of the lens, let alone how these change with age. This understanding is needed if we are to accurately predict or assess the long-term effects of refractive surgical procedures or ophthalmic prostheses on vision. In this project, we aim to substantially improve our understanding of the optical properties of the eye by ....Vision is limited by both optical and retinal-neural factors. Our understanding of the optical structure of the human eye is limited, partcularly for the refractive index gradient of the lens, let alone how these change with age. This understanding is needed if we are to accurately predict or assess the long-term effects of refractive surgical procedures or ophthalmic prostheses on vision. In this project, we aim to substantially improve our understanding of the optical properties of the eye by 1) developing methods for measuring these quantities and then applying the methods to investigate how these properties vary with age and focussing, and 2) determine the optical contribution to reduction in visual performance with increasing age. Our research will be used to determine norms for growth and aging patterns in the normal human eye, particularly the lens. It will yield significant outcomes through 1. determination of the long-term success of custom refractive surgery aimed at improving vision by eliminating the ocular aberrations, and 2. indicating the potential improvement in ocular performance provided by artificial intraocular lenses or any other type of correction.Read moreRead less
Longitudinal Eye Changes- Examining The Emergence Of Visual Impairment In Adolescents
Funder
National Health and Medical Research Council
Funding Amount
$103,582.00
Summary
Assessment of eye health parameter changes and emergence of visual impairment in a five year follow-up study of adolescents. Documenting the prevalence and incidence for the development of strabismus, ambylopia, hyperopic and myopic refractive errors, high-myopia , and the factors that promote or inhibit their early detection and remediation. This research is aimed at developing school-based and community-based strategies for minimising the life-long impact of these conditions
Improving Vision And Quality Of Life: An Innovative And Comprehensive Eye Care Model For Individuals In Residential Care Facilities
Funder
National Health and Medical Research Council
Funding Amount
$896,953.00
Summary
Elderly people living in residential care facilities have high levels of vision loss which can impact on emotional health, falls, daily functioning, and quality of life. Appropriate correction and cataract surgery can improve vision and, with low vision rehabilitation, can enhance quality of life. This project will assess the efficacy and cost-effectiveness of a new model of eye care targeting vision impairment to improve residents’ daily functioning, enhance their emotional well-being and quali ....Elderly people living in residential care facilities have high levels of vision loss which can impact on emotional health, falls, daily functioning, and quality of life. Appropriate correction and cataract surgery can improve vision and, with low vision rehabilitation, can enhance quality of life. This project will assess the efficacy and cost-effectiveness of a new model of eye care targeting vision impairment to improve residents’ daily functioning, enhance their emotional well-being and quality of life; and reduce falls.Read moreRead less
Vision problems in young children can impact on educational attainment, employment opportunities and quality of life. Although severe eye disease is recognised shortly after birth, there are no Australian population-based data on the magnitude, frequency and risk factors for conditions causing moderate or milder levels of visual impairment in one or both eyes, particularly refractive error, amblyopia and strabismus. There is widespread evidence that mild or unilateral visual impairment in young ....Vision problems in young children can impact on educational attainment, employment opportunities and quality of life. Although severe eye disease is recognised shortly after birth, there are no Australian population-based data on the magnitude, frequency and risk factors for conditions causing moderate or milder levels of visual impairment in one or both eyes, particularly refractive error, amblyopia and strabismus. There is widespread evidence that mild or unilateral visual impairment in young children is frequently unrecognised and that this can sometimes lead to important adverse health outcomes. While recent data suggests that early detection and treatment could reduce development of permanent and more severe disability in the long-term, there is no consensus that screening is cost effective. The proposed study will estimate the frequency and examine risk factors and impacts from a number of childhood vision conditions in over 4,000 children, aged 6 months to under 6 years. The population sample will be derived by performing door-to-door counts of children in a random cluster sample of census districts in the Sydney region, following letter box and media publicity. Based on similar surveys we have conducted, we expect to examine at least 75% of eligible children. They will have detailed vision and eye tests using standardised methods. We will align these to methods used in a large sister US study. The project will have sufficient power to provide accurate and reliable information about conditions affecting vision in young children. These data will inform debate and assist in designing interventions to reduce disability in children from visual impairments. The multidisciplinary team has expertise in epidemiology, paediatric eye disease and in conducting vision assessments, plus a strong track record in population-based research.Read moreRead less
Therapeutic Control Of Pathological Myopia: Role Of Transforming Growth Factor-beta
Funder
National Health and Medical Research Council
Funding Amount
$312,730.00
Summary
Myopia (shortsightedness) is due to the eye being too long. It is a common refractive disorder, affecting some 25-30% of people in developed countries, and results in blurred distance vision. The optical consequences of myopia, namely blurred distance vision, are correctable with spectacles or contact lenses. However, a significant minority of individuals (3% of the Australian population) have excessively long eyes and high amounts of myopia. These enlarged eyes impose abnormal stresses on the s ....Myopia (shortsightedness) is due to the eye being too long. It is a common refractive disorder, affecting some 25-30% of people in developed countries, and results in blurred distance vision. The optical consequences of myopia, namely blurred distance vision, are correctable with spectacles or contact lenses. However, a significant minority of individuals (3% of the Australian population) have excessively long eyes and high amounts of myopia. These enlarged eyes impose abnormal stresses on the structures inside, particularly affecting the retina, which is the light sensitive part of the eye. Damage that occurs to the retina in these eyes is, at present, untreatable and irreversible and can result in blindness. Myopia is the 2nd leading cause of blindness amongst adults of working age. For the eye to grow so large, its white outer coat (the sclera) must expand without allowing any leaks of the delicate structures and fluids inside. Although the sclera gets very thin as it expands, it has been shown that this process of expansion is a biochemically active process and not due to passive stretch. Before elongation of the eye can occur the biochemical structure of the sclera must change, a complex process involving accelerated production and breakdown of the biochemical building blocks of the sclera. Previous research in our laboratory indicates that changes in structure of the sclera are associated with reduced levels of the growth-controlling protein transforming growth factor-beta (TGF-beta). The aim of this project is to supplement TGF-beta levels in the sclera in order to reverse the loss of scleral tissue, stop the development of myopia and, therefore, prevent the development of the sight-threatening pathology associated with high myopia. In addition, we will determine the most effective way to deliver a sustained dose of TGF-beta to the sclera.Read moreRead less
Translation Of Genetic Findings Into Improved Health Outcomes For Common Eye Diseases In Our Society
Funder
National Health and Medical Research Council
Funding Amount
$675,736.00
Summary
Associate Professor Paul Baird of the Centre for Eye Research Australia, University of Melbourne specialises in identifying and understanding how genetic changes are involved in causing the commonest causes of vision loss and blindness in our society including age related macular degeneration, short-sightedness and glaucoma. His Fellowship will be used to better understand how genes and environment cause these diseases, allowing translation of findings intto new and improved treatments for patie ....Associate Professor Paul Baird of the Centre for Eye Research Australia, University of Melbourne specialises in identifying and understanding how genetic changes are involved in causing the commonest causes of vision loss and blindness in our society including age related macular degeneration, short-sightedness and glaucoma. His Fellowship will be used to better understand how genes and environment cause these diseases, allowing translation of findings intto new and improved treatments for patients.Read moreRead less
The Mechanism Of Action Of Muscarinic Receptor Antagonists In Preventing Axial Myopia
Funder
National Health and Medical Research Council
Funding Amount
$242,545.00
Summary
Myopia (short-sightedness) is the most common refractive error and is due to the eye being too long and, if uncorrected, results in blurred distance vision. Approximately 30% of the population in developed countries, such as Australia, suffer from myopia. In a significant minority of individuals with high degrees of myopia, it is a sight threatening condition and a leading cause of blindness. It has been found that the pharmacological agent, atropine, is effective in preventing myopia in childre ....Myopia (short-sightedness) is the most common refractive error and is due to the eye being too long and, if uncorrected, results in blurred distance vision. Approximately 30% of the population in developed countries, such as Australia, suffer from myopia. In a significant minority of individuals with high degrees of myopia, it is a sight threatening condition and a leading cause of blindness. It has been found that the pharmacological agent, atropine, is effective in preventing myopia in children and in animal models of myopia. However the side effects of blurred vision at near, glare from dilated pupils and the unknown long term effects of chronic atropine treatment have prevented this approach to myopia control from becoming an established treatment in children. It was originally thought that the drug worked by preventing the eye from accommodating for near objects, however it has now been shown that atropine does not to work by this mechanism, but rather by another non-accommodative mechanism. The aim of this project is to determine the mechanism of action of this class of drugs (known as muscarinic antagonists) in preventing myopic eye growth. The project will investigate in which ocular tissues the various subtypes of muscarinic receptors sensitive to these drugs are located and how these are changed in myopic eyes. It will also determine the specific receptor subtype these drugs act on and whether these drugs inhibit eye growth in myopia by altered retinal signalling activity. The results from this study will elucidate the mechanism and route of action of muscarinic antagonists in preventing myopic eye growth. These findings will advance the probability of developing an effective selective muscarinic antagonist drug to use for the prevention of axial myopia without the side effects associated with the broad-band antagonist atropine. The development of such drugs will have a major economic benefit to the Australian population.Read moreRead less