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Investigating Healing Outcomes In People With Venous Ulcers: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$340,834.00
Summary
Venous leg ulcers (VLU) are an extremely common, debilitating, costly problem and the burden is expected to rise with the ageing population, obesity and diabetes. Standard best practice treatment includes compression bandaging of the lower leg by tight bandaging. Application of 3 layer (3L) tubular bandage appears to be a promising new treatment according to a pilot study. We will conduct a randomised controlled trial to investigate improvement in healing with 3L and to measure cost-effectivenes ....Venous leg ulcers (VLU) are an extremely common, debilitating, costly problem and the burden is expected to rise with the ageing population, obesity and diabetes. Standard best practice treatment includes compression bandaging of the lower leg by tight bandaging. Application of 3 layer (3L) tubular bandage appears to be a promising new treatment according to a pilot study. We will conduct a randomised controlled trial to investigate improvement in healing with 3L and to measure cost-effectiveness when compared to standard compression.Read moreRead less
Exploring Neurological Complications In Animal Models Of Metabolic Disease
Funder
National Health and Medical Research Council
Funding Amount
$337,432.00
Summary
Diabetes causes ongoing damage to the central and peripheral nervous systems. Our research aims to understand the mechanisms of nervous system damage in diabetes by investigating changes in nervous system function overtime in animal models of pre-diabetes, type 2 diabetes and type 1 diabetes. This study specifically aims to utilize indices that can be correlated with measures obtainable in human studies and thereby achieve results with strong clinical relevance and potential for translation.
Combined Therapy To Ameliorate Ventilatory Instability In Patients With Heart Failure And Sleep Apnea
Funder
National Health and Medical Research Council
Funding Amount
$386,648.00
Summary
Sleep apnea is highly prevalent, particularly in patients with heart failure, and treatment remains limited to applying pressure via a face mask which can be intolerable. Although instability in breathing control is a major cause of apnea in many patients, treatments targeting instability with sufficient efficacy are unavailable. This project will combine two treatments, acetazolamide and oxygen, to powerfully reduce instability and provide relief from sleep apnea in a subgroup of patients.
Women with diabetes in pregnancy and their babies are more likely to have health problems, e.g. preeclampsia, being born early, or admitted to neonatal intensive care unit. We know that lowering mum’s blood glucose to the levels found in women without diabetes is important but does not prevent problems completely. The purpose of these studies is to look at the other parts of metabolism that are different in women with diabetes e.g. blood fats, so we can understand if we should address them.
The Genetic And Environmental Risk For Pregnancy Complications And Subsequent Metabolic Syndrome
Funder
National Health and Medical Research Council
Funding Amount
$350,891.00
Summary
The major problems in late pregnancy are preeclampsia, gestational diabetes and babies who are small or are born prematurely. Women who develop these pregnancy complications and men who father them are at risk of later life coronary heart disease (CHD). The purpose of this study is to develop tests to identify couples at risk of CHD early in pregnancy. If we can predict this risk early, targeted interventions can be implemented to reduce the risk of pregnancy complications and subsequent CHD.
Effects Of RHDL On Diabetes In TRAIL-deficient Mice.
Funder
National Health and Medical Research Council
Funding Amount
$294,892.00
Summary
Diabetes is a chronic disease affecting 275 people daily in Australia. People with diabetes have a 2-4 fold greater risk for developing cardiovascular disease (CVD). TRAIL (TNF-related apoptosis-inducing ligand) can promote cell growth and death selectively. High density lipoproteins are shown to protect against diabetes and CVD. Understanding the mechanism(s) that mediate this process may lead to the design of therapeutic agents to reduce suffering of patients with diabetes and CVD.
Improving The Fetal To Neonatal Transition In Compromised Newborns; Towards Better Outcomes For Babies Born Too Soon Or With Under-developed Lungs
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
The birth of a compromised infant affects 13 million pregnancies worldwide annually and is the greatest cause of neonatal death, disability and chronic disease. I will identify mechanisms to greatly improve the fetal to neonatal transition in premature babies and babies with under-developed lungs. This research is urgently required to provide the necessary evidence to target interventions in the delivery room to reduce the short- and long-term burden of disease in compromised newborns.
Premature Cardiovascular Death In Women After Hypertensive Pregnancy: Altering This Trajectory
Funder
National Health and Medical Research Council
Funding Amount
$189,384.00
Summary
Women with preeclampsia, the “high blood pressure disease of pregnancy” also have at least double the long-term risk of the biggest killers of Australian women, heart attacks and stroke. This research program aims to (a) identify high-risk women in the first year after preeclampsia (b) develop educational programs for patients and doctors to increase understanding of long-term risks of and promote appropriate follow-up (c) trial potential treatments to reduce long-term risk.