Identification, Validation And Functional Analysis Of Genes And MiRNAs Involved In Recurrent Non-small Cell Lung Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$104,664.00
Summary
Recurrence of lung cancer after treatment affects 20-85% of patients. Current prognostication tools are inaccurate and thus patients receive generic treatments. Our intention is to identify genes involved in recurrence of lung cancer. We foresee that this will translate to earlier identification of at-risk patients enabling individualised less toxic and more successful treatments. We also hope to better understand biology of lung cancer recurrence and discover new targets for treatment.
Prevention Of Late Breast Cancer (BC) Events In Postmenopausal Women With Endocrine Responsive BC.
Funder
National Health and Medical Research Council
Funding Amount
$4,687,599.00
Summary
This proposal is from Australia's national breast cancer (BC) trials group, the ANZ BCTG, for a new phase III, multi-centre clinical trial evaluating whether much later endocrine therapy with an aromatase inhibitor can prevent BC recurrence in postmenopausal women who have: had hormone sensitive BC at least 6 years ago; were treated by Tamoxifen more than 1 year ago; and, are currently disease free. Subjects will randomly receive letrozole or placebo as a daily tablet for five years.
Sun Exposure, Vitamin D And The Outcome Of Prostate Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$494,698.00
Summary
We will find out whether hours of sun exposure, reported in a standard interview by men with prostate cancer, reduces prostate cancer recurrence and progression. For any effect of sun exposure ithat we observe, we will find out whether it works through vitamin D, which is produced by sunshine on the skin, or is affected by changes in the vitamin D receptor gene, which produces the protein the binds with vitamin D on cells and makes it work. Prostate cancer is the most common cancer in men in Aus ....We will find out whether hours of sun exposure, reported in a standard interview by men with prostate cancer, reduces prostate cancer recurrence and progression. For any effect of sun exposure ithat we observe, we will find out whether it works through vitamin D, which is produced by sunshine on the skin, or is affected by changes in the vitamin D receptor gene, which produces the protein the binds with vitamin D on cells and makes it work. Prostate cancer is the most common cancer in men in Australia, and this study, using two of the largest collections of clinical outcomes data for this disease, will inform researchers, clinicians and consumers about the possible benefits of sun exposure and Vitamin D in the prevention of recurrence or progression of prostate cancer. On present evidence, these effects are very plausible possibilities. It may also identify sub-groups of men in whom sun exposure or vitamin D might be particularly beneficial in improving outcome of prostate cancer.Read moreRead less
POST-OPERATIVE CROHNS DISEASE RECURRENCE: EVALUATION OF AETIOLOGIC FACTORS And AN ALGORITHM And TRIAL TO MODIFY RECURRENCE.
Funder
National Health and Medical Research Council
Funding Amount
$123,472.00
Summary
Eighty percent of patients with Crohn’s disease (CD) need an operation at some stage. The disease invariably returns, and in 70% of patients further surgery is required. This project aims to determine whether particular bacteria cause the disease to recur and will look at the value of antibiotic treatment to prevent severe disease recurring. It will also assess whether adjusting treatment based on changes seen at the operative site during follow-up influences disease recurrence .
Identifying Risk For Second And Subsequent Pregnancies: A Longitudinal Record Linkage Study
Funder
National Health and Medical Research Council
Funding Amount
$586,129.00
Summary
Interventions (eg. induction of labour) or conditions (eg bleeding) in one pregnancy may affect outcomes in the next pregnancy (eg. risk of complications). These relationships are under-investigated. Using population data on over 194,000 women we can look at repeat pregnancies experienced by individual women. We will use this data to investigate whether interventions in one pregnancy affect subsequent birth outcomes (for mother or baby) and whether particular conditions are likely to recur.
The starting point for this project is the recent finding that women who experience miscarriages or terminations of pregnancy before theuir first birth have an increased risk of having a preterm (premature) infant. These findings have prompted a re-evaluation of the relationship between the number of pregnancies a women has had and the likely outcome in later pregnancies. It will take into account the stage at which prior pregnancies ended, what the outcomes of the pregnancies were (birth, healt ....The starting point for this project is the recent finding that women who experience miscarriages or terminations of pregnancy before theuir first birth have an increased risk of having a preterm (premature) infant. These findings have prompted a re-evaluation of the relationship between the number of pregnancies a women has had and the likely outcome in later pregnancies. It will take into account the stage at which prior pregnancies ended, what the outcomes of the pregnancies were (birth, health baby, death, baby with a birth defect, termination, miscarriage etc), as well as factors such as maternal age, in relation to the risks in subsequent pregnancies. The expected outcomes and significance of the study are: * new evidence about factors causing adverse outcomes of pregnancy; * better information on the risk of recuurence of common birth defects; * more precise information on risks of adverse pregnancy outcomes for users and planners of maternity services.Read moreRead less
PlaTFORM: PrevenTing Falls In A High Risk, Vision Impaired Population Through Specialist ORientation And Mobility Services: A Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$773,768.00
Summary
While many older people fall causing injury and loss of confidence, people with vision impairment and blindness have a dramatically increased risk of falls. In the PlaTFORM study we will deliver and comprehensively evaluate a falls prevention program through instructors with specialised training in orientation and mobility. This fills a gap in services and if effective will prevent injury in this vulnerable population and promote mobility.
How Does The Trunk Influence Intersegmental Coordination During Functional Tasks In Parkinson’s Disease: A Risk Factor For Falls?
Funder
National Health and Medical Research Council
Funding Amount
$328,032.00
Summary
Differences in trunk motion during dynamic tasks may provide a mechanism of falling in Parkinson’s disease (PD) patients. However, objective measures are needed to discern if these differences stem from deficits in motor programming or increased trunk stiffness. This information is critical for developing effective interventions. This project will incorporate innovative techniques to examine how the trunk muscles coordinate movement and control balance during walking in PD.
Better Evidence And New Tools To Improve Health After Surgical Menopause
Funder
National Health and Medical Research Council
Funding Amount
$1,855,260.00
Summary
Surgical menopause is removal of both ovaries before natural menopause. Surgical menopause may have severe adverse health consequences including short-term symptoms and long-term risk of chronic disease, but more information is needed to inform evidence-based care. This study will deliver the best available evidence internationally on the short (up to 5 year) and long (>20 year) consequences of surgical menopause and new tools for clinicians and patients to integrate this evidence into practi ....Surgical menopause is removal of both ovaries before natural menopause. Surgical menopause may have severe adverse health consequences including short-term symptoms and long-term risk of chronic disease, but more information is needed to inform evidence-based care. This study will deliver the best available evidence internationally on the short (up to 5 year) and long (>20 year) consequences of surgical menopause and new tools for clinicians and patients to integrate this evidence into practiceRead moreRead less