Progesterone Receptor-mediated Coordination Of Oocyte-oviduct Communication During Ovulation
Funder
National Health and Medical Research Council
Funding Amount
$86,128.00
Summary
Infertility affects 1 in 6 couples, often due to failed release of an egg from the ovary. The hormone progesterone is essential for this process. Our goal is to determine how progesterone signals the egg to ensure its correct release into the oviduct where fertilization may occur. To identify these signals, experiments will analyse ovary cells and eggs of mice, including mice that do not respond to progesterone. The results will provide much needed information about female reproductive health.
Pushing AR Toward Better Outcomes In Breast And Prostate Cancers
Funder
National Health and Medical Research Council
Funding Amount
$998,754.00
Summary
Breast and prostate cancers kill >6000 Australians each year. These cancers are strikingly similar, both driven by hormone receptors that have ‘gone bad’. Current therapies aim to eradicate the receptors. While often effective, therapeutic resistance is common and results in fatal disease. We aim to develop new, less toxic treatments that switch receptor behaviour from good to bad, without destroying them. This should improve quality of life, while preventing drug resistance and loss of lives ....Breast and prostate cancers kill >6000 Australians each year. These cancers are strikingly similar, both driven by hormone receptors that have ‘gone bad’. Current therapies aim to eradicate the receptors. While often effective, therapeutic resistance is common and results in fatal disease. We aim to develop new, less toxic treatments that switch receptor behaviour from good to bad, without destroying them. This should improve quality of life, while preventing drug resistance and loss of lives.Read moreRead less
Regulation Of VEGFR Trafficking And Signal Transduction By The Ubiquitin Ligase Nedd4
Funder
National Health and Medical Research Council
Funding Amount
$388,347.00
Summary
Our recent work has discovered that the Nedd4 gene is crucial for the growth and development of blood vessels and lymphatic vessels. Our data suggest that Nedd4 controls vessel growth by regulating the levels and signalling activity of the key vascular growth factor receptors VEGFR-2 and VEGFR-3. The goals of this proposal are to define precisely how Nedd4-1 regulates the activity of these receptors and how VEGFR signalling could be better targeted to treat vascular disorders.
Trafficking Mechanisms Governing Receptor Availability For Signalling
Funder
National Health and Medical Research Council
Funding Amount
$526,978.00
Summary
Receptors on the cell surface allow cells to respond to their environment. We have recently discovered a new pathway for controlling the amount of receptors displayed on the cell surface, errors within which will lead to defects in development and diseases like cancer. We are studying how this new pathway controls the balance between how much receptors are destroyed after being activated and how much are recycled back for re-use.
Special Research Initiatives - Grant ID: SR0354693
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in ....Australian e-Research Grid. The e-Research Grid program will research and implement core Grid technologies on APAC and partner's deployed HPC resources, to underpin a broad range of Australian research. The computer science CIs will form collaborative links with international programs, adapting developments to local circumstances. The applications-domain CIs will leverage those into their scientific simulations and databases, using grid integrative techniques and portals. Many CIs participate in other RNs linking to their motivating applications, enhancing prospects for research and integration. They participate in the APAC Grid program, leveraging 75 HPC staff nationally. A key aim is interoperability with "real-world Grids": eg e-learning & e-health programs.Read moreRead less
The impact of strategic alignment on IT outsourcing success in a complex service setting. Improved conceptual and methodological understanding of strategic alignment is essential for better IT outsourcing decisions. This research will improve the performance of Australian industry by investigating how strategically well aligned ITO investments can lead to improved performance and greater competitive advantage.
A Platform for Rapid and Flexible Development of Context-Aware Web Services. Context awareness is one of the most exciting trends in computing today, and it holds the potential to make our daily life more productive, convenient and enjoyable. The proposed project will produce a comprehensive platform for developing context-aware Web services, which will facilitate ready implementation of many innovative applications and make important contributions to Australian society and the national economy. ....A Platform for Rapid and Flexible Development of Context-Aware Web Services. Context awareness is one of the most exciting trends in computing today, and it holds the potential to make our daily life more productive, convenient and enjoyable. The proposed project will produce a comprehensive platform for developing context-aware Web services, which will facilitate ready implementation of many innovative applications and make important contributions to Australian society and the national economy. One such application is an intelligent seniors assistance service that will improve quality of life for senior citizens while helping them maintain an independent lifestyle. This project will also place Australia at the forefront of Web service development.Read moreRead less
Development of a Global Decision Support System towards Virtual Manufacturing. The aim of this research project is to develop a global decision support system (GDSS) in order to assist SMEs to improve their competitiveness in the dynamic global market while providing an industry oriented research training for a high calibre PhD student, who would be a valuable asset to Australia. The GDSS will help SMEs leverage their operations in a global context and to adopt a realistic virtual manufacturing ....Development of a Global Decision Support System towards Virtual Manufacturing. The aim of this research project is to develop a global decision support system (GDSS) in order to assist SMEs to improve their competitiveness in the dynamic global market while providing an industry oriented research training for a high calibre PhD student, who would be a valuable asset to Australia. The GDSS will help SMEs leverage their operations in a global context and to adopt a realistic virtual manufacturing system in the future. The significance of the project includes developing a new methodology and a GDSS to assess virtual manufacturing issues for SMEs and assisting them making timely decisions.Read moreRead less