An Interdisciplinary Approach Towards Antiviral Therapy Discovery
Funder
National Health and Medical Research Council
Funding Amount
$2,000,000.00
Summary
Viruses cause significant life-threatening diseases and our armament against viral infections is extremely limited. When coupled with resistance development, humanity is at the mercy of existing and emerging life-threatening viruses. This project will provide new insight into how clinically- significant viruses that cause flu, croup and hand foot and mouth disease attack human cells, as well as discover new drug candidates that combat these viruses.
Understanding Cell Signalling As A Basis For New Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$2,231,372.00
Summary
This Investigator grant will capitalise on my extensive expertise in determining the three-dimensional atomic structures of proteins to uncover fundamental biological mechanisms in cancer and Alzheimer’s disease as a basis for discovering new drugs to combat these devastating diseases.
Mechanisms Of Cell Death Driven Inflammation In The Skin
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
Inflammatory skin conditions are a leading cause of disease. Current therapies treat symptoms not causes of inflammation. Skin cells constantly interact with cells of the immune system, and with a diverse array of helpful and harmful microorganisms. My data suggest a role of the skin flora and resident immune cells in the initiation and progression of skin disease. I will investigate how the microbiota and immune cells can initiate cell death and drive excessive immune responses in the skin.