The Australian Research Data Commons (ARDC) invites you to participate in a short survey about your
interaction with the ARDC and use of our national research infrastructure and services. The survey will take
approximately 5 minutes and is anonymous. It’s open to anyone who uses our digital research infrastructure
services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
deliver and to report on user satisfaction to the Australian Government’s National Collaborative Research
Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
Lung Injury: Influence Of Sodium, Water, Albumin, Gravity And Body Position
Funder
National Health and Medical Research Council
Funding Amount
$117,331.00
Summary
Although patients with poor oxygenation often require mechanical ventilation, only therapies that reduce lung damage improve outcome whereas therapies that improve oxygenation have not been shown to improve outcome. This project will examine the role of two common interventions in critically ill patients, fluid resuscitation and posture change, on lung injury. It is anticipated this will lead to clinical trials that will further improve survival in ventilated patients with respiratory failure.
Effects Of A Novel Hotspot Mutation Of Brm In Non-Melanoma Skin Cancer Development
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
Australia has the highest incidence of skin cancer in the world. SWI/SNF, a yeast nucleosome remodeling complex, is known destabilise interactions in DNA. It is made up of 8-10 proteins, including a novel tumour suppressor Brm. There is some evidence that Brm acts as a tumour suppressor in skin cancer, but relevance of a recently found mutation in Brm is yet to be characterised. This project aims to identify the effect of this mutation, on cellular sensitivity to UV radiation and examine transfo ....Australia has the highest incidence of skin cancer in the world. SWI/SNF, a yeast nucleosome remodeling complex, is known destabilise interactions in DNA. It is made up of 8-10 proteins, including a novel tumour suppressor Brm. There is some evidence that Brm acts as a tumour suppressor in skin cancer, but relevance of a recently found mutation in Brm is yet to be characterised. This project aims to identify the effect of this mutation, on cellular sensitivity to UV radiation and examine transformation to malignancy.Read moreRead less
Characterisation Of Autoreactive T Cells In Chronic Idiopathic Urticaria Would Improve Its Diagnosis And Treatment.
Funder
National Health and Medical Research Council
Funding Amount
$97,182.00
Summary
Chronic idiopathic urticaria (CIU) is a disease in which itchy hives recur due to no apparent trigger. It is an autoimmune disease in which the immune system reacts against certain cells in the skin, called mast cells and basophils. It is unclear how this occurs. Once activated, mast cells and basophils release a chemical called histamine, which is responsible for the rash. I aim to identify the immune reactions that occur in CIU, develop reliable tests for diagnosis and improve treatment of CIU ....Chronic idiopathic urticaria (CIU) is a disease in which itchy hives recur due to no apparent trigger. It is an autoimmune disease in which the immune system reacts against certain cells in the skin, called mast cells and basophils. It is unclear how this occurs. Once activated, mast cells and basophils release a chemical called histamine, which is responsible for the rash. I aim to identify the immune reactions that occur in CIU, develop reliable tests for diagnosis and improve treatment of CIU.Read moreRead less
Inflammatory skin disorders, such as psoriasis and dermatitis, are responsible for a large burden of human disease and affect people across alldemographics. Knockout (KO) of TNF signalling members in mice is known to induce skin inflammation. This project proposes to use these genetic mouse models to investigate how and why disruption of particular TNF superfamily members leads to disease and potentially identify new targets for treatment.
Improving 3D Scaffolds For Skin Tissue Engineering Using Advanced Biotechnology
Funder
National Health and Medical Research Council
Funding Amount
$68,971.00
Summary
Burns injuries are among the most physically and psychologically debilitating injuries. Patients who suffer from severe, extensive burn injuries can have a shortage of healthy, undamaged donor sites and so skin substitutes are used as alternatives to provide wound healing. However, the newly produced skin does not appear or function normally. The aim of this project is to develop a skin equivalent which will provide rapid regeneration of normal skin and improve a patient’s quality of life.
The Role Of Flightless In The Formation Of Scar Formation And Potential As A Target For A Novel Therapy To Reduce Scarring
Funder
National Health and Medical Research Council
Funding Amount
$60,664.00
Summary
Scarring causes significant morbidity and suffering. It can lead to pain, disfigurement and impaired physical function, which require costly ongoing care. Flightless (Flii) is a novel protein, which acts as a negative regulator of wound healing. Flii neutralising antibody treatment has been shown to improve wound healing. However, the role of Flii in scarring has yet to be investigated. This project will investigate the role of Flii in scarring and its potential as a therapeutic target.