Novel, High-throutyput Platform For Rapid Identification, Quantintation, Differential Diagnosis, And Resistance Testing
Funder
National Health and Medical Research Council
Funding Amount
$333,362.00
Summary
This proposal utilizes a newly invented process (multiplex tandem polymerase chain reaction, MT-PCR) to measure multiple (up to 100) genetic targets (eg RNA or DNA) in one sample. A range of different virus and bacterial genes can be detected, including those which make the influenza virus different (eg H1N1 or H5N1) and allow it to bypass vaccine immunity or resist drug therapy (due to neuraminidase inhibitor resistance). We will simultaneously target infections which are influenza-like (ILI) o ....This proposal utilizes a newly invented process (multiplex tandem polymerase chain reaction, MT-PCR) to measure multiple (up to 100) genetic targets (eg RNA or DNA) in one sample. A range of different virus and bacterial genes can be detected, including those which make the influenza virus different (eg H1N1 or H5N1) and allow it to bypass vaccine immunity or resist drug therapy (due to neuraminidase inhibitor resistance). We will simultaneously target infections which are influenza-like (ILI) or which might make influenza infection worse (eg staphylococcal pneumonia) as well as their resistance genes (eg MRSA). The test is rapid and automated and includes a specimen processing (DNA and RNA extraction) function that is being developed in parallel. We expect to be able to conduct high-throughput screening of multiple samples for a limited number of targets or conduct multiple tests on fewer specimens, simply by adjusting assay configuration. Measurement of the rise and fall in concentrations of influenza virus in infected persons will allow us to understand when they are no longer infectious to others, to predict when they are getting better or worse, and allow us to better understand the pattern of illness in people who are immunized against influenza or on drug therapy, or are in some other special category (eg immune compromise due to organ transplantation). While this will be able to be rolled out by our industry partners in the event of an influenza pandemic, it does not require an outbreak for successful development, and has value well beyond influenza diagnosis.Read moreRead less
Systematic Revision Of The Australian Fishes Of The Family Pomadasyidae
Funder
Fisheries Research and Development Corporation
Summary
Objectives: 1. Study the fishes of the family Pomadasyidae in the scientific collection of the Australian Museum Sydney & the National Museum Melbourne
The development of the Fishnames project has been an ongoing concern for industry and the Fisheries Research Development Corporation.
The terms of reference (ToR) have been developed and wll be provided to workshop participants for consideration and feedback. The ToR include:
1) Report that details recommended changes to the objectives of the Fishnames process.
2) Changes to the Fishnames process.
3) The composition of the Fishnames committee.
4) Brie ....The development of the Fishnames project has been an ongoing concern for industry and the Fisheries Research Development Corporation.
The terms of reference (ToR) have been developed and wll be provided to workshop participants for consideration and feedback. The ToR include:
1) Report that details recommended changes to the objectives of the Fishnames process.
2) Changes to the Fishnames process.
3) The composition of the Fishnames committee.
4) Brief ‘user friendly’ summary of the project and outcomes suitable for publication on the FRDC website. Objectives: 1. Recommend changes to the objectives of the Fishnames process. 2. Chang to the Fishnames process. 3. The composition of the Fishnames committee. 4. A brief ‘user friendly’ summary of the project and outcomes suitable for publication on the FRDC website Read moreRead less
The Optimization Of Rapid Diagnostic Tests (RDTs) For Malaria
Funder
National Health and Medical Research Council
Funding Amount
$44,934.00
Summary
The ability to reliably diagnose malaria infections is key to both the management of individual patients as well as public health efforts to control the disease. Current Rapid Diagnostic Tests (RDTs) for malaria have unacceptable sensitivity. The project will determine the low sensitivity of current malaria RDTs available on the market and help produce a malaria RDT with higher sensitivity and stability. This will bring great health benefits to millions of people.
Predicting, Diagnosing And Treating Synucleinopathies
Funder
National Health and Medical Research Council
Funding Amount
$3,738,220.00
Summary
Parkinson’s Disease and Lewy Body Dementia carry a high socioeconomic burden and there are currently no disease-modifying treatments. Existing symptomatic therapies focus on replacing neurotransmitters that are made by neurons that have mostly degenerated prior to clinical diagnosis, warranting a clear need to identify cases at a stage when they might benefit most from neuroprotective interventions, as well as improving symptomatic and developing disease modifying treatments.
A Program To Develop A Consensus As To "marketing" Names Of Fish Throughout Australia And To Publicise To The Trade And To The Public These "marketing" Names
Funder
Fisheries Research and Development Corporation
Summary
Objectives: 1. Enable production of a list of Australian and imported commercial fish, showing the scientific names, local names in each State and a suggested marketing name for each variety