Cardiometabolic Changes After Continuous Positive Airway Pressure Treatment For Obstructive Sleep Apnea
Funder
National Health and Medical Research Council
Funding Amount
$82,421.00
Summary
CPAP is the preferred treatment for patients with OSA because of its well-proven ability to decrease sleepiness and improve blood pressure control. This study will definitively establish if CPAP can also improve markers of cardio-metabolic health, such as visceral fat, insulin sensitivity, central blood pressure and arterial stiffness. The results of the study will shed light on the broader health consequences of OSA and contributes to the development of more targeted treatment strategies.
Examining The Role Of HIF-1a And Snail-2 In Radiosensitivity Of Oropharyngeal Squamous Cell Carcinoma
Funder
National Health and Medical Research Council
Funding Amount
$78,492.00
Summary
Human papillomavirus (HPV)-induced oropharyngeal squamous cell carcinoma has a significantly better prognosis than that caused by tobacco and/or alcohol. The favorable prognosis is due to a better response to treatment with radiation therapy and chemotherapy but the exact mechanisms are still not clear. This project will investigate these mechanisims at the molecular level and ultimately it will lead us to the development of strategies to improve the response of both HPV and non-HPV induced orop ....Human papillomavirus (HPV)-induced oropharyngeal squamous cell carcinoma has a significantly better prognosis than that caused by tobacco and/or alcohol. The favorable prognosis is due to a better response to treatment with radiation therapy and chemotherapy but the exact mechanisms are still not clear. This project will investigate these mechanisims at the molecular level and ultimately it will lead us to the development of strategies to improve the response of both HPV and non-HPV induced oropharyngeal cancer to radiation therapy.Read moreRead less
Enhancement Of The Anti-tumour Efficacy Of Ionising Radiation Through Inhibition Of Phosphoinositide 3-kinase
Funder
National Health and Medical Research Council
Funding Amount
$123,503.00
Summary
Radiation treatment alone is given to many cancer patients, however often it does not prevent cancers from recurring. Significant promise is offered by new drugs that target molecules which play a key role in cancer growth, and combining these drugs with radiation treatment may lead to improved patient outcomes. Understanding how these drugs enhance the anti-cancer effects of radiation is critical to selecting the most appropriate patients for treatment with this combination.