Tracking Epidermal Clonal Evolution During Skin Cancer Induction And Progression
Funder
National Health and Medical Research Council
Funding Amount
$558,168.00
Summary
Skin cancer is the most frequent form of cancer in Australia and in many parts of the world. It is strongly connected to ultraviolet radiation from the sun. In this project, we will use our capacity to track individual cells, to observe the heterogeneity of tumours and the lesions that precede them. We will show the importance of this heterogeneity in tumour progression unveiling the limits of current therapies against skin cancer.
Discovery Early Career Researcher Award - Grant ID: DE140100433
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Optimising light harvesting using quantum transport. Observations of wavelike energy transport in photosynthetic systems have exposed the role of quantum mechanics in natural light harvesting. This project is a study of how light harvesting functions for an incoherent source like sunlight. In sunlight, energy transport occurs at steady state, a dramatically simpler regime than when a coherent source like lasers are used. This project will exploit this simplification to develop new methods for tr ....Optimising light harvesting using quantum transport. Observations of wavelike energy transport in photosynthetic systems have exposed the role of quantum mechanics in natural light harvesting. This project is a study of how light harvesting functions for an incoherent source like sunlight. In sunlight, energy transport occurs at steady state, a dramatically simpler regime than when a coherent source like lasers are used. This project will exploit this simplification to develop new methods for treating light harvesting in sunlight and apply them to a variety of natural and artificial systems. It will clarify how bacteria and plants harvest sunlight and lead to design principles that will enable artificial light harvesting to take advantage of quantum effects.Read moreRead less
Modelling quantum dynamics of electronic excited states in complex molecular materials. Understanding new materials that are the basis of new sources of renewable energy sources represents a major scientific challenge. Many of these materials are composed of large organic molecules containing hundreds of atoms. Their properties and the concepts needed to understand these materials are distinctly different from semiconductors such as silicon. This research will enhance our ability to design bett ....Modelling quantum dynamics of electronic excited states in complex molecular materials. Understanding new materials that are the basis of new sources of renewable energy sources represents a major scientific challenge. Many of these materials are composed of large organic molecules containing hundreds of atoms. Their properties and the concepts needed to understand these materials are distinctly different from semiconductors such as silicon. This research will enhance our ability to design better materials and optimize the performance of organic solar cells and LEDs. Australia's capacity for research and development in this scientifically challenging and technologically important field will be enhanced by this project. Read moreRead less
Mitochondrially targeted anti-cancer drugs modulate the mitochondrial genome. Successful cancer management requires novel therapeutical approaches. This project will test the effect of a new class of compounds that target mitochondria, the powerhouse of the cells, where they suppress expression of mitochondrial genes. By this mechanism, cancers that are resistant to apoptosis induction can be inhibited.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668398
Funder
Australian Research Council
Funding Amount
$177,900.00
Summary
Advanced Microwave Facility for Quantum-Atom Optics. Atoms can be controlled using light in visible and infra-red regions, as well as electromagnetic waves of longer wavelength in the microwave (MW) and radiofrequency (RF) part of the spectrum. We presently use optical radiation to control atoms at the quantum level where they can behave like waves and can interact with light to store and manipulate information. The MW and RF facility will extend our abilities and enable more complete control of ....Advanced Microwave Facility for Quantum-Atom Optics. Atoms can be controlled using light in visible and infra-red regions, as well as electromagnetic waves of longer wavelength in the microwave (MW) and radiofrequency (RF) part of the spectrum. We presently use optical radiation to control atoms at the quantum level where they can behave like waves and can interact with light to store and manipulate information. The MW and RF facility will extend our abilities and enable more complete control of the atoms, which will help us develop the first generation quantum technology. This will enable the creation of quantum devices such as atom lasers, atom interferometers and quantum information networks for communication and ultra-sensitive measurement applications.Read moreRead less
Entanglement as resource for quantum technology. This project focuses on groundbreaking research in quantum information theory, an exciting new area of fundamental physics that underpins the development of quantum technologies. Australia has already invested heavily in one particular quantum technology: computation. Our project, if successful, will enable an Australian research effort into other quantum technologies for communication, metrology, data storage and security. This project will as ....Entanglement as resource for quantum technology. This project focuses on groundbreaking research in quantum information theory, an exciting new area of fundamental physics that underpins the development of quantum technologies. Australia has already invested heavily in one particular quantum technology: computation. Our project, if successful, will enable an Australian research effort into other quantum technologies for communication, metrology, data storage and security. This project will assist in elevating Australia to a major international research centre in quantum information theory, complementing its existing strength in experiment, and will provide extensive training of early career researchers.Read moreRead less
Optical realisations of continuous-variable quantum information. The project aims to develop a framework for optical realisations of continuous-variable quantum information. Such realisations offer the potential for major technological advances in quantum information processing in the near future, but are currently impeded by the lack of a well-defined theoretical foundation. This project aims to construct such a foundation, including energy cutoffs, detector resolution, and finite resources. ....Optical realisations of continuous-variable quantum information. The project aims to develop a framework for optical realisations of continuous-variable quantum information. Such realisations offer the potential for major technological advances in quantum information processing in the near future, but are currently impeded by the lack of a well-defined theoretical foundation. This project aims to construct such a foundation, including energy cutoffs, detector resolution, and finite resources. Feasible experiments to test and exploit continuous-variable quantum information processing will be proposed. The resulting framework will allow the field to progress beyond proof-of-principle demonstrations and to develop new, technology-driven quantum information protocols.Read moreRead less
ARC Complex Open Systems Research Network. Complexity is the common frontier in the physical, biological and social sciences. This Network will link specialists in all three sciences through five generic conceptual and mathematical theme activities. It will promote research into how subsystems self-organise into new emergent structures when assembled into an open, non-equilibrium system. Outcomes will include new technologies and software tools and deeper understanding of fundamental questions i ....ARC Complex Open Systems Research Network. Complexity is the common frontier in the physical, biological and social sciences. This Network will link specialists in all three sciences through five generic conceptual and mathematical theme activities. It will promote research into how subsystems self-organise into new emergent structures when assembled into an open, non-equilibrium system. Outcomes will include new technologies and software tools and deeper understanding of fundamental questions in science. An essential function of the network will be introducing researchers end users to new tools and broadening the horizons of graduate students.Read moreRead less
Controlling quantum technologies. Australia is a leader in quantum technology - from molecular machines to quantum computers, amazing advances are being made possible as we harness the laws of quantum physics. Our project will enhance the nation's profile in this discipline by developing some of the ground rules for measuring and controlling the operation of quantum devices. This foundational work will put Australian theoretical and experimental researchers at the forefront of this new field, an ....Controlling quantum technologies. Australia is a leader in quantum technology - from molecular machines to quantum computers, amazing advances are being made possible as we harness the laws of quantum physics. Our project will enhance the nation's profile in this discipline by developing some of the ground rules for measuring and controlling the operation of quantum devices. This foundational work will put Australian theoretical and experimental researchers at the forefront of this new field, and there is significant opportunity for development of intellectual property such as patents. Young researchers and postgraduate students will play a substantial role in the project, maximising the training impact for new professionals in cutting-edge science and high technology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453320
Funder
Australian Research Council
Funding Amount
$347,886.00
Summary
Advanced Spectroscopy for Nano-characterisation of Materials Chemistry and Properties. This application proposes to establish a cutting-edge spectroscopic facility which includes; electron energy-loss spectroscopy (EELS), energy-dispersive X-ray spectroscopy (EDS), cathodoluminescence (CL), photoluminescence (PL) and micro-Raman spectroscopy. Each of the spectrometers to be installed has significantly higher sensitivity and resolution than any other facility available in Australia and is capable ....Advanced Spectroscopy for Nano-characterisation of Materials Chemistry and Properties. This application proposes to establish a cutting-edge spectroscopic facility which includes; electron energy-loss spectroscopy (EELS), energy-dispersive X-ray spectroscopy (EDS), cathodoluminescence (CL), photoluminescence (PL) and micro-Raman spectroscopy. Each of the spectrometers to be installed has significantly higher sensitivity and resolution than any other facility available in Australia and is capable of full spectrum imaging. This new spectroscopic infrastructure will enable the knowledge-based development of new materials by allowing complete characterisation of structure-composition-property relationships at the nanometre level.Read moreRead less