The critical role of the class III histone deacetylase SIRT2 in stabilizing N-Myc oncoprotein. Cancer is the commonest cause of death from disease in children. Neuroblastoma is the commonest solid tumor in early childhood. This project will investigate the critical roles of SIRT2 protein in increasing the expression of N-Myc oncoprotein and consequently inducing neuroblastoma, and SIRT2 inhibitors as anticancer agents.
Interplay of the forces of nature: electroweak and strong interactions. The Large Hadron Collider in Switzerland will search for new physics by smashing protons together at the highest energies ever created in the laboratory. This project will focus on complementary searches for new physics by investigating novel phenomena associated with the mutual interactions of the strong and weak forces of nature.
Quantum control in mesoscopic condensed matter systems. Semiconductor devices are at the foundation of modern technology. Industrial nanofabrication techniques can now produce devices near the atomic scale, and state-of-the-art experiments have demonstrated the previously unimaginable ability to manipulate individual electrons. This project will develop new techniques to control such quantum circuits and couple them together to form useful devices. New experiments to test these schemes will be p ....Quantum control in mesoscopic condensed matter systems. Semiconductor devices are at the foundation of modern technology. Industrial nanofabrication techniques can now produce devices near the atomic scale, and state-of-the-art experiments have demonstrated the previously unimaginable ability to manipulate individual electrons. This project will develop new techniques to control such quantum circuits and couple them together to form useful devices. New experiments to test these schemes will be proposed. This project will provide a foundation for future information processing technologies such as quantum computers.Read moreRead less
Self-Assembled Semiconductor Nanowires: A New Platform for Spintronic Devices. The multi-billion dollar semiconductor industry drives the extraordinary growth in information technology that we have witnessed in recent decades. This Fellowship will establish a new program to build electronic devices using tiny semiconductor 'nanowires'. It draws on UNSW's international reputation in nanoelectronics research, strongly enhances Australia's existing investment in the growth of nanowires at ANU, an ....Self-Assembled Semiconductor Nanowires: A New Platform for Spintronic Devices. The multi-billion dollar semiconductor industry drives the extraordinary growth in information technology that we have witnessed in recent decades. This Fellowship will establish a new program to build electronic devices using tiny semiconductor 'nanowires'. It draws on UNSW's international reputation in nanoelectronics research, strongly enhances Australia's existing investment in the growth of nanowires at ANU, and will place Australia at the forefront of nanowire research on the international stage. This project will contribute strongly to Australia's ongoing efforts in semiconductor nanotechnology and quantum information science, and allow us to play a leading role in the development of next-generation computer technologies.Read moreRead less
Microscopic many-body quantum dynamics: new approaches for fundamental science and applications. A new approach to create and validate a fundamental microscopic quantum theory of interactions of composite systems, like molecules and nuclei, by exploiting ideal features of nuclear reactions such as fusion will be developed. This will have broad impact in interdisciplinary areas from astrophysics and molecular reactions to future nanotechnologies.
Two-dimensional quantum turbulence in superfluid atomic gases. This project will controllably generate and study turbulence in two-dimensional superfluids. With quantum fluids as models to understand two-dimensional fluid dynamics, this project aims to provide a better generic understanding of physical mechanisms behind phenomena as diverse as cyclone dynamics and the stability of the planet Jupiter's Great Red Spot.
Spin-orbit-coupled Bose-Einstein Condensates. This project will explore fundamentally new quantum states, the spin-orbit Bose-Einstein condensates, predicted theoretically by Galitski et al. and subsequently observed experimentally. These states host a variety of fascinating novel phenomena, which can be exploited for ultra-sensitive interferometry and topological quantum computing. The project will develop a complete description of these phases and design new quantum devices that utilise their ....Spin-orbit-coupled Bose-Einstein Condensates. This project will explore fundamentally new quantum states, the spin-orbit Bose-Einstein condensates, predicted theoretically by Galitski et al. and subsequently observed experimentally. These states host a variety of fascinating novel phenomena, which can be exploited for ultra-sensitive interferometry and topological quantum computing. The project will develop a complete description of these phases and design new quantum devices that utilise their properties. The fundamental significance of the project is in bringing together ideas from the diverse fields of atomic and molecular physics, condensed matter, quantum information, and topology and its direct relevance to the development of a new generation of quantum devices.Read moreRead less
Collision physics in lighting, fusion and astrophysical plasmas. The project will apply advanced fundamental science techniques to applications that have a high impact on the environment. These include improving energy efficiency of fluorescent lamps and development of new mercury-free designs and research in support of the international multi-billion dollar fusion energy program.
Quantum Opto-Mechatronics. Quantum science is the precise study of the physical world in the nanoscopic realm. It accurately predicts a wide range of physical phenomena that have no classical analogues. Understanding and controlling these quantum phenomena will play an increasingly important role in transforming 21st century technologies. This fellowship aims to realise the potential of combining optical, mechanical, and atomic systems in the quantum regime to deliver quantum enhancement to a ra ....Quantum Opto-Mechatronics. Quantum science is the precise study of the physical world in the nanoscopic realm. It accurately predicts a wide range of physical phenomena that have no classical analogues. Understanding and controlling these quantum phenomena will play an increasingly important role in transforming 21st century technologies. This fellowship aims to realise the potential of combining optical, mechanical, and atomic systems in the quantum regime to deliver quantum enhancement to a range of applications such as future-proofing information security via quantum cryptography and improving sensor technology with quantum measurement.Read moreRead less
Molecular hallmarks of androgen receptor targeting in prostate cancer. There is a critical need in oncology drug development for better biomarkers of response to prostate cancer therapies, clinically to assist with treatment decision making, and pre-clinically to facilitate translation of emerging agents into clinical practice. Using a unique explant culture model, this project will identify protein and lipid markers that can be used to accurately and reliably assess response to androgen recepto ....Molecular hallmarks of androgen receptor targeting in prostate cancer. There is a critical need in oncology drug development for better biomarkers of response to prostate cancer therapies, clinically to assist with treatment decision making, and pre-clinically to facilitate translation of emerging agents into clinical practice. Using a unique explant culture model, this project will identify protein and lipid markers that can be used to accurately and reliably assess response to androgen receptor (AR)-targeting therapies in human prostate tumours. The identification and functional assessment of these biomarkers will identify those that can be used as surrogate endpoints in clinical trials, facilitate earlier approval of investigational agents and lead to improved options for therapeutic management of prostate cancer.Read moreRead less