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Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
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Cancer Imaging And Targeted Radiation Therapy: From Discovery To Clinical Practice
Funder
National Health and Medical Research Council
Funding Amount
$2,114,215.00
Summary
This program will create a new pipeline of cancer imaging and targeted radiotherapy medical devices, translating discoveries to new first-in-world clinical trials and engaging with industry to see these innovations used in broad clinical practice. The research is applicable to all major cancer types and radiation therapy is essential for cancer cure and symptom control for half of all cancer patients, success means a global real-world impact on the lives of millions of cancer patients.
Investigating Post-transcriptional Gene Regulation In Cancer
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
In this program, I will enhance our understanding of cancer gene regulation and provide novel avenues for the treatment of aggressive tumours. Using own data and that from collaborators, I will determine patterns of gene regulation in blood cancers and identify markers that predict disease outcome. I aim to understand how gene regulation can transform healthy cells into tumour cells and whether personalised treatment can kill tumour cells more effectively and prevent relapse and metastasis.
Deciphering Mechanisms Underlying Breast Cancer To Improve Patient Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$3,314,215.00
Summary
Breast cancer is a highly heterogeneous disease. Patients are often treated in a ‘one size fits all’ approach, but response to therapy remains disparate. To more effectively personalise therapy, there is a pressing need to define the precise cell types and initiating genetic events that give rise to breast cancer. This application is centred on understanding mechanisms of breast cancer initiation and progression, with the potential of identifying new prognostic markers and therapeutic targets.
Genetics Of Epilepsy: Completing Our Understanding
Funder
National Health and Medical Research Council
Funding Amount
$3,000,000.00
Summary
Finding genetic causes of epilepsies is vital for accurate diagnosis and family counseling, to optimize current treatments and to develop novel therapies. We will leverage our large collection of carefully evaluated Australian cases with international data sets, coordinated by Consortia that I chair, to develop a detailed understanding of the genetic causes of epilepsy. This will transform the use of genetics in the clinic, lead to better immediate treatment and aid in developing novel therapies
An Interdisciplinary Approach Towards Antiviral Therapy Discovery
Funder
National Health and Medical Research Council
Funding Amount
$2,000,000.00
Summary
Viruses cause significant life-threatening diseases and our armament against viral infections is extremely limited. When coupled with resistance development, humanity is at the mercy of existing and emerging life-threatening viruses. This project will provide new insight into how clinically- significant viruses that cause flu, croup and hand foot and mouth disease attack human cells, as well as discover new drug candidates that combat these viruses.
Structural Biology Of Malaria Parasite Invasion And Antibodies-mediated Inhibition
Funder
National Health and Medical Research Council
Funding Amount
$1,562,250.00
Summary
Malaria results in significant mortality but an effective vaccine does not yet exist. The Rh5-CyRPA-Ripr complex is essential for malaria parasite to invade erythrocytes and is the leading vaccine candidate. We aim to visualise the atomic details of the Rh5-CyRPA-Ripr complex during parasite invasion of erythrocytes and how antibodies neutralise this key protein complex. This information will advance knowledge on malaria parasite invasion, which will help to design an effective malaria vaccine.
Understanding Cell Signalling As A Basis For New Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$2,231,372.00
Summary
This Investigator grant will capitalise on my extensive expertise in determining the three-dimensional atomic structures of proteins to uncover fundamental biological mechanisms in cancer and Alzheimer’s disease as a basis for discovering new drugs to combat these devastating diseases.
Targeting Epigenetic Mechanisms Of Immune Evasion In Cancer
Funder
National Health and Medical Research Council
Funding Amount
$1,425,280.00
Summary
Proteins called MHC class I and II on the surface of cancer cells act as sensors that allow the immune system to recognise cancer cells as abnormal and destroy them. However, cancer cells have developed ways to hide from the immune system by silencing MHC class I and II. This project aims to identify ways to overcome this silencing and restore MHC class I and II to the surface of the cancer cells, allowing them to be treated with therapies that activate immune cells to eradicate the tumour.
Targeting Iron Piracy From Host Proteins By Neisseria And Haemophilus Spp. For The Development Of Novel Antimicrobials
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
The bacteria that cause the sexually transmitted infection gonorrhoea and meningococcal disease are a serious health concern. In order to cause disease, these bacteria must obtain the nutrient iron from our bodies. This proposed research will use cutting edge technologies to understand on a molecular level how these bacteria obtain iron during infection. It will then apply this knowledge to develop molecules that prevent these bacteria from obtaining iron, as a means of treating these diseases.
Tipping The Balance - Improving Response Rates To Cancer Immunotherapy
Funder
National Health and Medical Research Council
Funding Amount
$1,562,250.00
Summary
Survival rates for some types of cancer remain low. It was previously thought that chemotherapy could not be combined with drugs that affect the immune system (immunotherapy) to treat cancer. My research disproved this. I develop models to study cancer in the lab. I also research ways to measure how people’s bodies respond to chemotherapy and immunotherapy (biomarkers). I use this information to discover new drug combinations to reduce deaths from cancer.